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Protein
Submitted name:

Nuclear factor of-activated T-cells, cytoplasmic 1

Gene

NFATC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 1Imported
Gene namesi
Name:NFATC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000131196.17
HGNCiHGNC:7775 NFATC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131196

PTM / Processingi

Proteomic databases

PeptideAtlasiK7ER53
PRIDEiK7ER53

Expressioni

Gene expression databases

BgeeiENSG00000131196 Expressed in 198 organ(s), highest expression level in muscle organ
ExpressionAtlasiK7ER53 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7ER53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini410 – 568RHDInterPro annotationAdd BLAST159

Phylogenomic databases

eggNOGiENOG410IHFR Eukaryota
ENOG41105U2 LUCA
GeneTreeiENSGT00550000074562

Family and domain databases

Gene3Di2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR008366 NFAT
IPR015647 NFAT1
IPR008967 p53-like_TF_DNA-bd
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR12533 PTHR12533, 1 hit
PTHR12533:SF5 PTHR12533:SF5, 1 hit
PfamiView protein in Pfam
PF00554 RHD_DNA_bind, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS50254 REL_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

K7ER53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSTSFPVPS KFPLGPAAAV FGRGETLGPA PRAGGTMKSA EEEHYGYASS
60 70 80 90 100
NVSPALPLPT AHSTLPAPCH NLQTSTPGII PPADHPSGYG AALDGGPAGY
110 120 130 140 150
FLSSGHTRPD GAPALESPRI EITSCLGLYH NNNQFFHDVE VEDVLPSSKR
160 170 180 190 200
SPSTATLSLP SLEAYRDPSC LSPASSLSSR SCNSEASSYE SNYSYPYASP
210 220 230 240 250
QTSPWQSPCV SPKTTDPEEG FPRGLGACTL LGSPRHSPST SPRASVTEES
260 270 280 290 300
WLGARSSRPA SPCNKRKYSL NGRQPPYSPH HSPTPSPHGS PRVSVTDDSW
310 320 330 340 350
LGNTTQYTSS AIVAAINALT TDSSLDLGDG VPVKSRKTTL EQPPSVALKV
360 370 380 390 400
EPVGEDLGSP PPPADFAPED YSSFQHIRKG GFCDQYLAVP QHPYQWAKPK
410 420 430 440 450
PLSPTSYMSP TLPALDWQLP SHSGPYELRI EVQPKSHHRA HYETEGSRGA
460 470 480 490 500
VKASAGGHPI VQLHGYLENE PLMLQLFIGT ADDRLLRPHA FYQVHRITGK
510 520 530 540 550
TVSTTSHEAI LSNTKVLEIP LLPENSMRAV IDCAGILKLR NSDIELRKGE
560 570 580 590 600
TDIGRKNTRP SAQLRSCLWW RSRARTAIRS WAGRRWSCLA TTSCRTPRSF
610 620 630
SWRKPQMATM SGRWKRKLTG TCASRILWWL RSRHFGIRG
Length:639
Mass (Da):69,430
Last modified:January 9, 2013 - v1
Checksum:i40C293EE1005FA78
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95644NFAC1_HUMAN
Nuclear factor of activated T-cells...
NFATC1 NFAT2, NFATC
943Annotation score:
F5H4S8F5H4S8_HUMAN
Nuclear factor of-activated T-cells...
NFATC1
471Annotation score:
K7EQ04K7EQ04_HUMAN
Nuclear factor of-activated T-cells...
NFATC1
71Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018445 Genomic DNA No translation available.
AC023090 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000587635; ENSP00000468111; ENSG00000131196
UCSCiuc010xff.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018445 Genomic DNA No translation available.
AC023090 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7ER53
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiK7ER53
PRIDEiK7ER53

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587635; ENSP00000468111; ENSG00000131196
UCSCiuc010xff.3 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000131196.17
HGNCiHGNC:7775 NFATC1
OpenTargetsiENSG00000131196
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHFR Eukaryota
ENOG41105U2 LUCA
GeneTreeiENSGT00550000074562

Miscellaneous databases

ChiTaRSiNFATC1 human

Gene expression databases

BgeeiENSG00000131196 Expressed in 198 organ(s), highest expression level in muscle organ
ExpressionAtlasiK7ER53 baseline and differential

Family and domain databases

Gene3Di2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR008366 NFAT
IPR015647 NFAT1
IPR008967 p53-like_TF_DNA-bd
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR12533 PTHR12533, 1 hit
PTHR12533:SF5 PTHR12533:SF5, 1 hit
PfamiView protein in Pfam
PF00554 RHD_DNA_bind, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS50254 REL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7ER53_HUMAN
AccessioniPrimary (citable) accession number: K7ER53
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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