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Protein
Submitted name:

CXXC-type zinc finger protein 1

Gene

CXXC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 209CXXC-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
CXXC-type zinc finger protein 1Imported
Gene namesi
Name:CXXC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000154832.14
HGNCiHGNC:24343 CXXC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154832

PTM / Processingi

Proteomic databases

PeptideAtlasiK7EQZ1
PRIDEiK7EQZ1

Expressioni

Gene expression databases

BgeeiENSG00000154832 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiK7EQZ1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EQZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 76PHD-typeInterPro annotationAdd BLAST51
Domaini160 – 209CXXC-typeInterPro annotationAdd BLAST50

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 209CXXC-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1632 Eukaryota
ENOG410YG6P LUCA
GeneTreeiENSGT00730000111044

Family and domain databases

InterProiView protein in InterPro
IPR037852 CXXC1
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR12321:SF99 PTHR12321:SF99, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

K7EQZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGDGSDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF
60 70 80 90 100
HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDGNERDSS
110 120 130 140 150
EPRDEGGGRK RPVPDPDLQR RAGSGTGVGA MLARGSASPH KSSPQPLVAT
160 170 180 190 200
PSQHHQQQQQ QIKRSARMCG ECEACRRTED CGHCDFCRDM KKFGGPNKIR
210 220 230 240 250
QKCRLRQCQL RARLSPVTPS ESLPRPRRPL PTQQQPQPSQ KLGRIREDEG

AV
Length:252
Mass (Da):28,581
Last modified:October 5, 2016 - v8
Checksum:i13E88A21B42DE1CC
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9P0U4CXXC1_HUMAN
CXXC-type zinc finger protein 1
CXXC1 CFP1, CGBP, PCCX1, PHF18
656Annotation score:
K7EQ21K7EQ21_HUMAN
CXXC finger 1 (PHD domain), isoform...
CXXC1 hCG_23689
613Annotation score:
K7EKZ6K7EKZ6_HUMAN
CXXC-type zinc finger protein 1
CXXC1
250Annotation score:
K7EJR0K7EJR0_HUMAN
CXXC-type zinc finger protein 1
CXXC1
231Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei252Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090246 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000589548; ENSP00000468038; ENSG00000154832
UCSCiuc060peb.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090246 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EQZ1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiK7EQZ1
PRIDEiK7EQZ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000589548; ENSP00000468038; ENSG00000154832
UCSCiuc060peb.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000154832.14
HGNCiHGNC:24343 CXXC1
OpenTargetsiENSG00000154832
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1632 Eukaryota
ENOG410YG6P LUCA
GeneTreeiENSGT00730000111044

Miscellaneous databases

ChiTaRSiCXXC1 human

Gene expression databases

BgeeiENSG00000154832 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiK7EQZ1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR037852 CXXC1
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR12321:SF99 PTHR12321:SF99, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EQZ1_HUMAN
AccessioniPrimary (citable) accession number: K7EQZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 51 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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