UniProtKB - K7EQP4 (K7EQP4_HUMAN)
Protein
Submitted name:
Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial
Gene
ACADVL
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Very long-chain-specific acyl-CoA dehydrogenase, mitochondrialImported |
Gene namesi | Name:ACADVLImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:92, ACADVL |
VEuPathDBi | HostDB:ENSG00000072778.19 |
Expressioni
Gene expression databases
Bgeei | ENSG00000072778, Expressed in left lobe of thyroid gland and 247 other tissues |
ExpressionAtlasi | K7EQP4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 96 – 207 | Acyl-CoA_dh_NInterPro annotationAdd BLAST | 112 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 42 | DisorderedSequence analysisAdd BLAST | 20 |
Phylogenomic databases
GeneTreei | ENSGT00940000158535 |
HOGENOMi | CLU_107859_0_0_1 |
Family and domain databases
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF56645, SSF56645, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
K7EQP4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQAARMAASL GRQLLRLGGG SSRLTALLGQ PRPGPARRPY AGGAAQLALD
60 70 80 90 100
KSDSHPSDAL TRKKPAKAES KSFAVGMFKG QLTTDQVFPY PSVLNEEQTQ
110 120 130 140 150
FLKELVEPVS RFFEEVNDPA KNDALEMVEE TTWQGLKELG AFGLQVPSEL
160 170 180 190 200
GGVGLCNTQY ARLVEIVGMH DLGVGITLGA HQSIGFKGIL LFGTKAQKEK
210 220
YLPKLASALS PTGETVAAFC LTEP
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP49748 | ACADV_HUMAN | Very long-chain specific acyl-CoA d... | ACADVL VLCAD | 655 | Annotation score: | ||
J3QKU9 | J3QKU9_HUMAN | Very long-chain-specific acyl-CoA d... | ACADVL | 155 | Annotation score: | ||
K7EJW8 | K7EJW8_HUMAN | Very long-chain-specific acyl-CoA d... | ACADVL | 157 | Annotation score: | ||
J9JID6 | J9JID6_HUMAN | Very long-chain-specific acyl-CoA d... | ACADVL | 39 | Annotation score: | ||
J3KS89 | J3KS89_HUMAN | Very long-chain-specific acyl-CoA d... | ACADVL | 76 | Annotation score: | ||
J3KSR4 | J3KSR4_HUMAN | Very long-chain-specific acyl-CoA d... | ACADVL | 204 | Annotation score: | ||
G3V1M7 | G3V1M7_HUMAN | Very long-chain-specific acyl-CoA d... | ACADVL | 282 | Annotation score: | ||
J3QRJ8 | J3QRJ8_HUMAN | Very long-chain-specific acyl-CoA d... | ACADVL | 194 | Annotation score: | ||
K7EMF8 | K7EMF8_HUMAN | Very long-chain-specific acyl-CoA d... | ACADVL | 45 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 224 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120057 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000583312; ENSP00000467920; ENSG00000072778 |
UCSCi | uc060ain.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120057 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | K7EQP4 |
PRIDEi | K7EQP4 |
Protocols and materials databases
Antibodypediai | 11798, 282 antibodies |
Genome annotation databases
Ensembli | ENST00000583312; ENSP00000467920; ENSG00000072778 |
UCSCi | uc060ain.1, human |
Organism-specific databases
HGNCi | HGNC:92, ACADVL |
OpenTargetsi | ENSG00000072778 |
VEuPathDBi | HostDB:ENSG00000072778.19 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158535 |
HOGENOMi | CLU_107859_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACADVL, human |
Gene expression databases
Bgeei | ENSG00000072778, Expressed in left lobe of thyroid gland and 247 other tissues |
ExpressionAtlasi | K7EQP4, baseline and differential |
Family and domain databases
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF56645, SSF56645, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K7EQP4_HUMAN | |
Accessioni | K7EQP4Primary (citable) accession number: K7EQP4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | October 5, 2016 | |
Last modified: | February 10, 2021 | |
This is version 52 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |