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Protein
Submitted name:

Amyloid-like protein 1

Gene

APLP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid-like protein 1Imported
Gene namesi
Name:APLP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105290.11
HGNCiHGNC:597 APLP1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105290

PTM / Processingi

Proteomic databases

PeptideAtlasiK7EQJ4
PRIDEiK7EQJ4

Expressioni

Gene expression databases

BgeeiENSG00000105290 Expressed in 147 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiK7EQJ4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EQJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 114A4_EXTRAInterPro annotationAdd BLAST114

Phylogenomic databases

eggNOGiENOG410IT8P Eukaryota
ENOG4111MXY LUCA
GeneTreeiENSGT00530000063252

Family and domain databases

Gene3Di1.20.120.770, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
InterProiView protein in InterPro
IPR036669 Amyloid_Cu-bd_sf
IPR008155 Amyloid_glyco
IPR011178 Amyloid_glyco_Cu-bd
IPR024329 Amyloid_glyco_E2_domain
IPR008154 Amyloid_glyco_extra
IPR019744 Amyloid_glyco_extracell_CS
IPR015849 Amyloid_glyco_heparin-bd
IPR036454 Amyloid_glyco_heparin-bd_sf
IPR036176 E2_sf
PANTHERiPTHR23103 PTHR23103, 1 hit
PfamiView protein in Pfam
PF12924 APP_Cu_bd, 1 hit
PF12925 APP_E2, 1 hit
PF02177 APP_N, 1 hit
PRINTSiPR00203 AMYLOIDA4
SMARTiView protein in SMART
SM00006 A4_EXTRA, 1 hit
SUPFAMiSSF109843 SSF109843, 1 hit
SSF56491 SSF56491, 1 hit
SSF89811 SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319 A4_EXTRA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

K7EQJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYPELQIARV EQATQAIPME RWCGGSRSGS CAHPHHQVVP FRCLPGEFVS
60 70 80 90 100
EALLVPEGCR FLHQERMDQC ESSTRRHQEA QEACSSQGLI LHGSGMLLPC
110 120 130 140 150
GSDRFRGVEY VCCPPPGTPD PSGTAVGDPS TRSWPPGSRV EGAEDEEEEE
160 170 180 190 200
SFPQPVDDYF VEPPQAEEEE ETVPPPSSHT LAVVGKVTPT PRPTDGVDIY
210 220 230 240 250
FGMPGEISEH EGFLRAKMDL EERRMRQINE VMREWAMADN QSKNLPKADR
260 270 280 290
QALNEHFQSI LQTLEEQVSG ERQRLVETHA TRVIALINDQ RRAA
Length:294
Mass (Da):32,868
Last modified:January 9, 2013 - v1
Checksum:iF70E78AF244499F0
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P51693APLP1_HUMAN
Amyloid-like protein 1
APLP1
650Annotation score:
B7Z4G8B7Z4G8_HUMAN
cDNA FLJ56046, highly similar to Am...
APLP1
644Annotation score:
F5GZ08F5GZ08_HUMAN
Amyloid-like protein 1
APLP1
611Annotation score:
K7ELK0K7ELK0_HUMAN
Amyloid-like protein 1
APLP1
173Annotation score:
S4R3U6S4R3U6_HUMAN
Amyloid-like protein 1
APLP1
289Annotation score:
K7EMN4K7EMN4_HUMAN
Amyloid-like protein 1
APLP1
221Annotation score:
K7EMS1K7EMS1_HUMAN
Amyloid-like protein 1
APLP1
118Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei294Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD000864 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000592316; ENSP00000467854; ENSG00000105290
UCSCiuc060xkc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD000864 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EQJ4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiK7EQJ4
PRIDEiK7EQJ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000592316; ENSP00000467854; ENSG00000105290
UCSCiuc060xkc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000105290.11
HGNCiHGNC:597 APLP1
OpenTargetsiENSG00000105290
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT8P Eukaryota
ENOG4111MXY LUCA
GeneTreeiENSGT00530000063252

Miscellaneous databases

ChiTaRSiAPLP1 human

Gene expression databases

BgeeiENSG00000105290 Expressed in 147 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiK7EQJ4 baseline and differential

Family and domain databases

Gene3Di1.20.120.770, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
InterProiView protein in InterPro
IPR036669 Amyloid_Cu-bd_sf
IPR008155 Amyloid_glyco
IPR011178 Amyloid_glyco_Cu-bd
IPR024329 Amyloid_glyco_E2_domain
IPR008154 Amyloid_glyco_extra
IPR019744 Amyloid_glyco_extracell_CS
IPR015849 Amyloid_glyco_heparin-bd
IPR036454 Amyloid_glyco_heparin-bd_sf
IPR036176 E2_sf
PANTHERiPTHR23103 PTHR23103, 1 hit
PfamiView protein in Pfam
PF12924 APP_Cu_bd, 1 hit
PF12925 APP_E2, 1 hit
PF02177 APP_N, 1 hit
PRINTSiPR00203 AMYLOIDA4
SMARTiView protein in SMART
SM00006 A4_EXTRA, 1 hit
SUPFAMiSSF109843 SSF109843, 1 hit
SSF56491 SSF56491, 1 hit
SSF89811 SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319 A4_EXTRA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EQJ4_HUMAN
AccessioniPrimary (citable) accession number: K7EQJ4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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