UniProtKB - K7EQH5 (K7EQH5_HUMAN)
Protein
Submitted name:
Amino-terminal enhancer of split, isoform CRA_a
Gene
TLE5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Amino-terminal enhancer of split, isoform CRA_aImportedSubmitted name: TLE family member 5Imported |
Gene namesi | ORF Names:hCG_2005178Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104964.14 |
HGNCi | HGNC:307, TLE5 |
Subcellular locationi
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000104964, Expressed in cerebellar vermis and 246 other tissues |
ExpressionAtlasi | K7EQH5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 76 | TLE_NInterPro annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 141 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 120 – 141 | PolyampholyteSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the WD repeat Groucho/TLE family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT01010000222312 |
Family and domain databases
InterProi | View protein in InterPro IPR005617, Groucho/TLE_N IPR009146, Groucho_enhance |
PANTHERi | PTHR10814, PTHR10814, 1 hit |
Pfami | View protein in Pfam PF03920, TLE_N, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
K7EQH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQRHYVMYYE MSYGLNIEMH KQAEIVKRLN GICAQVLPYL SQEHQQQVLG
60 70 80 90 100
AIERAKQVTA PELNSIIRQQ LQAHQLSQLQ ALALPLTPLP VGLQPPSLPA
110 120 130 140
VSAGTGLLSL SALGSQAHLS KEDKNGHDGD THQEDDGEKS D
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ08117 | TLE5_HUMAN | TLE family member 5 | TLE5 AES, GRG, GRG5 | 197 | Annotation score: | ||
K7ELE3 | K7ELE3_HUMAN | TLE family member 5 | TLE5 | 264 | Annotation score: | ||
K7ELQ8 | K7ELQ8_HUMAN | TLE family member 5 | TLE5 | 48 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005944 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69341.1 |
Genome annotation databases
Ensembli | ENST00000586839; ENSP00000467831; ENSG00000104964 |
UCSCi | uc060rob.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005944 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69341.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | K7EQH5 |
Protocols and materials databases
Antibodypediai | 10920, 384 antibodies |
Genome annotation databases
Ensembli | ENST00000586839; ENSP00000467831; ENSG00000104964 |
UCSCi | uc060rob.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104964.14 |
HGNCi | HGNC:307, TLE5 |
OpenTargetsi | ENSG00000104964 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01010000222312 |
Miscellaneous databases
ChiTaRSi | AES, human |
Gene expression databases
Bgeei | ENSG00000104964, Expressed in cerebellar vermis and 246 other tissues |
ExpressionAtlasi | K7EQH5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR005617, Groucho/TLE_N IPR009146, Groucho_enhance |
PANTHERi | PTHR10814, PTHR10814, 1 hit |
Pfami | View protein in Pfam PF03920, TLE_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K7EQH5_HUMAN | |
Accessioni | K7EQH5Primary (citable) accession number: K7EQH5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | January 9, 2013 | |
Last modified: | December 2, 2020 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |