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UniProtKB - K7EQ95 (K7EQ95_HUMAN)
Protein
Submitted name:
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Gene
CACNA1A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotationARBA annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Voltage-dependent P/Q-type calcium channel subunit alpha-1A |
Gene namesi | Name:CACNA1A |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1388, CACNA1A |
VEuPathDBi | HostDB:ENSG00000141837 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- voltage-gated calcium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 56 – 74 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 86 – 109 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 177 – 195 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 273 – 297 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000141837, Expressed in right hemisphere of cerebellum and 212 other tissues |
ExpressionAtlasi | K7EQ95, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 434 – 468 | Ca_chan_IQInterPro annotationAdd BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 475 – 518 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 530 – 981 | DisorderedSequence analysisAdd BLAST | 452 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 530 – 553 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 584 – 598 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 609 – 628 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 679 – 696 | Basic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 697 – 733 | Basic and acidic residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 734 – 771 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 784 – 805 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 964 – 981 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156518 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR00167, CACHANNEL |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 22 potential isoforms that are computationally mapped.Show allAlign All
K7EQ95-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
QEQGDKMMEE YSLEKNERAC IDFAISAKPL TRHMPQNKQS FQYRMWQFVV
60 70 80 90 100
SPPFEYTIMA MIALNTIVLM MKFYGASVAY ENALRVFNIV FTSLFSLECV
110 120 130 140 150
LKVMAFGILN YFRDAWNIFD FVTVLGSITD ILVTEFGNNF INLSFLRLFR
160 170 180 190 200
AARLIKLLRQ GYTIRILLWT FVQSFKALPY VCLLIAMLFF IYAIIGMQVF
210 220 230 240 250
GNIGIDVEDE DSDEDEFQIT EHNNFRTFFQ ALMLLFRSAT GEAWHNIMLS
260 270 280 290 300
CLSGKPCDKN SGILTRECGN EFAYFYFVSF IFLCSFLMLN LFVAVIMDNF
310 320 330 340 350
EYLTRDSSIL GPHHLDEYVR VWAEYDPAAC GRIHYKDMYS LLRVISPPLG
360 370 380 390 400
LGKKCPHRVA CKRLLRMDLP VADDNTVHFN STLMALIRTA LDIKIAKGGA
410 420 430 440 450
DKQQMDAELR KEMMAIWPNL SQKTLDLLVT PHKSTDLTVG KIYAAMMIME
460 470 480 490 500
YYRQSKAKKL QAMREEQDRT PLMFQRMEPP SPTQEGGPGQ NALPSTQLDP
510 520 530 540 550
GGALMAHESG LKESPSWVTQ RAQEMFQKTG TWSPEQGPPT DMPNSQPNSQ
560 570 580 590 600
SVEMREMGRD GYSDSEHYLP MEGQGRAASM PRLPAENQTI SDTSPMKRSA
610 620 630 640 650
SVLGPKARRL DDYSLERVPP EENQRHHQRR RDRSHRASER SLGRYTDVDT
660 670 680 690 700
GLGTDLSMTT QSGDLPSKER DQERGRPKDR KHRQHHHHHH HHHHPPPPDK
710 720 730 740 750
DRYAQERPDH GRARARDQRW SRSPSEGREH MAHRQGSSSV SGSPAPSTSG
760 770 780 790 800
TSTPRRGRRQ LPQTPSTPRP HVSYSPVIRK AGGSGPPQQQ QQQQQQQQQQ
810 820 830 840 850
AVARPGRAAT SGPRRYPGPT AEPLAGDRPP TGGHSSGRSP RMERRVPGPA
860 870 880 890 900
RSESPRACRH GGARWPASGP HVSEGPPGPR HHGYYRGSDY DEADGPGSGG
910 920 930 940 950
GEEAMAGAYD APPPVRHASS GATGRSPRTP RASGPACASP SRHGRRLPNG
960 970 980
YYPAHGLARP RGPGSRKGLH EPYSESDDDW C
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO00555 | CAC1A_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A CACH4, CACN3, CACNL1A4 | 2,506 | Annotation score: | ||
A0A087WW63 | A0A087WW63_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,512 | Annotation score: | ||
B5TYJ1 | B5TYJ1_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,263 | Annotation score: | ||
A0A384DVW2 | A0A384DVW2_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,261 | Annotation score: | ||
A0A1B0GTI4 | A0A1B0GTI4_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,262 | Annotation score: | ||
A0A1B0GTN7 | A0A1B0GTN7_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,507 | Annotation score: | ||
A0A1B0GTW2 | A0A1B0GTW2_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,460 | Annotation score: | ||
A0A1B0GU74 | A0A1B0GU74_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,302 | Annotation score: | ||
A0A1B0GUS3 | A0A1B0GUS3_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,495 | Annotation score: | ||
A0A1C7CYY9 | A0A1C7CYY9_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,508 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005305 Genomic DNA No translation available. AC005513 Genomic DNA No translation available. AC011446 Genomic DNA No translation available. AC022436 Genomic DNA No translation available. AC026805 Genomic DNA No translation available. AC093062 Genomic DNA No translation available. AC098781 Genomic DNA No translation available. AC124224 Genomic DNA No translation available. KF456505 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000587525.5; ENSP00000467729.1; ENSG00000141837.22 |
UCSCi | uc060uih.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005305 Genomic DNA No translation available. AC005513 Genomic DNA No translation available. AC011446 Genomic DNA No translation available. AC022436 Genomic DNA No translation available. AC026805 Genomic DNA No translation available. AC093062 Genomic DNA No translation available. AC098781 Genomic DNA No translation available. AC124224 Genomic DNA No translation available. KF456505 Genomic DNA No translation available. |
3D structure databases
SMRi | K7EQ95 |
ModBasei | Search... |
Proteomic databases
MaxQBi | K7EQ95 |
PeptideAtlasi | K7EQ95 |
PRIDEi | K7EQ95 |
Protocols and materials databases
Antibodypediai | 26386, 93 antibodies from 22 providers |
Genome annotation databases
Ensembli | ENST00000587525.5; ENSP00000467729.1; ENSG00000141837.22 |
UCSCi | uc060uih.1, human |
Organism-specific databases
HGNCi | HGNC:1388, CACNA1A |
OpenTargetsi | ENSG00000141837 |
VEuPathDBi | HostDB:ENSG00000141837 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156518 |
Miscellaneous databases
ChiTaRSi | CACNA1A, human |
Gene expression databases
Bgeei | ENSG00000141837, Expressed in right hemisphere of cerebellum and 212 other tissues |
ExpressionAtlasi | K7EQ95, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR00167, CACHANNEL |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | K7EQ95_HUMAN | |
Accessioni | K7EQ95Primary (citable) accession number: K7EQ95 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | January 9, 2013 | |
Last modified: | May 25, 2022 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |