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Protein
Submitted name:

Periplakin

Gene

PPL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
PeriplakinImported
Gene namesi
Name:PPLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000118898.15
HGNCiHGNC:9273 PPL

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118898

PTM / Processingi

Proteomic databases

MaxQBiK7EQ71
PeptideAtlasiK7EQ71
PRIDEiK7EQ71

Expressioni

Gene expression databases

BgeeiENSG00000118898 Expressed in 206 organ(s), highest expression level in mouth mucosa
ExpressionAtlasiK7EQ71 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EQ71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 138Sequence analysisAdd BLAST21
Coiled coili181 – 201Sequence analysisAdd BLAST21
Coiled coili212 – 239Sequence analysisAdd BLAST28
Coiled coili313 – 347Sequence analysisAdd BLAST35
Coiled coili371 – 412Sequence analysisAdd BLAST42
Coiled coili424 – 472Sequence analysisAdd BLAST49
Coiled coili491 – 532Sequence analysisAdd BLAST42
Coiled coili551 – 585Sequence analysisAdd BLAST35
Coiled coili609 – 643Sequence analysisAdd BLAST35
Coiled coili669 – 703Sequence analysisAdd BLAST35
Coiled coili729 – 777Sequence analysisAdd BLAST49
Coiled coili796 – 868Sequence analysisAdd BLAST73
Coiled coili880 – 914Sequence analysisAdd BLAST35
Coiled coili930 – 1013Sequence analysisAdd BLAST84
Coiled coili1040 – 1060Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IQBN Eukaryota
ENOG410YHVZ LUCA
GeneTreeiENSGT00760000119163

Family and domain databases

InterProiView protein in InterPro
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
SMARTiView protein in SMART
SM00250 PLEC, 1 hit
SUPFAMiSSF75399 SSF75399, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

K7EQ71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSDLARLQE GRQPEHRDVT LQKVLDSEKL LYVLEADAAI AKHMKHPQGD
60 70 80 90 100
MIAEDIRQLK ERVTNLRGKH KQIYRLAVKE VDPQAQKSLL GEVEQNLQAA
110 120 130 140 150
KQCSSTLASR FQEHCPDLER QEAEVHKLGQ RFNNLRQQVE RRAQSLQSAK
160 170 180 190 200
AAYEHFHRGH DHVLQFLVSI PSYEPQETDS LSQMETKLKN QKNLLDEIAS
210 220 230 240 250
REQEVQKICA NSQQYQQAVK DYELEAEKLR SLLDLENGRR SHVSKRARLQ
260 270 280 290 300
SPATKVKEEE AALAAKFTEV YAINRQRLQN LEFALNLLRQ QPEVEVTHET
310 320 330 340 350
LQRNRPDSGV EEAWKIRKEL DEETERRRQL ENEVKSTQEE IWTLRNQGPQ
360 370 380 390 400
ESVVRKEVLK KVPDPVLEES FQQLQRTLAE EQHKNQLLQE ELEALQLQLR
410 420 430 440 450
ALEQETRDGG QEYVVKEVLR IEPDRAQADE VLQLREELEA LRRQKGAREA
460 470 480 490 500
EVLLLQQRVA ALAEEKSRAQ EKVTEKEVVK LQNDPQLEAE YQQLQEDHQR
510 520 530 540 550
QDQLREKQEE ELSFLQDKLK RLEKERAMAE GKITVKEVLK VEKDAATERE
560 570 580 590 600
VSDLTRQYED EAAKARASQR EKTELLRKIW ALEEENAKVV VQEKVREIVR
610 620 630 640 650
PDPKAESEVA NLRLELVEQE RKYRGAEEQL RSYQSELEAL RRRGPQVEVK
660 670 680 690 700
EVTKEVIKYK TDPEMEKELQ RLREEIVDKT RLIERCDLEI YQLKKEIQAL
710 720 730 740 750
KDTKPQVQTK EVVQEILQFQ EDPQTKEEVA SLRAKLSEEQ KKQVDLERER
760 770 780 790 800
ASQEEQIARK EEELSRVKER VVQQEVVRYE EEPGLRAEAS AFAESIDVEL
810 820 830 840 850
RQIDKLRAEL RRLQRRRTEL ERQLEELERE RQARREAERE VQRLQQRLAA
860 870 880 890 900
LEQEEAEARE KVTHTQKVVL QQDPQQAREH ALLRLQLEEE QHRRQLLEGE
910 920 930 940 950
LETLRRKLAA LEKAEVKEKV VLSESVQVEK GDTEQEIQRL KSSLEEESRS
960 970 980 990 1000
KRELDVEVSR LEARLSELEF HNSKSSKELD FLREENHKLQ LERQNLQLET
1010 1020 1030 1040 1050
RRLQSEINMA ATETRDLRNM TVADSGTNHD SRLWSLEREL DDLKRLSKDK
1060 1070 1080 1090 1100
DLEIDELQKR LGSVAVKREQ RENHLRRSIV VIHPDTGREL SPEEAHRAGL
1110
IDWNMFVKLR SQECD
Length:1,115
Mass (Da):131,375
Last modified:January 9, 2013 - v1
Checksum:i17CC46D0A3B6C7AF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O60437PEPL_HUMAN
Periplakin
PPL KIAA0568
1,756Annotation score:
K7EKI8K7EKI8_HUMAN
Periplakin
PPL
1,754Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1115Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027687 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000592772; ENSP00000467699; ENSG00000118898
UCSCiuc059qks.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027687 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EQ71
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiK7EQ71
PeptideAtlasiK7EQ71
PRIDEiK7EQ71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000592772; ENSP00000467699; ENSG00000118898
UCSCiuc059qks.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000118898.15
HGNCiHGNC:9273 PPL
OpenTargetsiENSG00000118898
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQBN Eukaryota
ENOG410YHVZ LUCA
GeneTreeiENSGT00760000119163

Gene expression databases

BgeeiENSG00000118898 Expressed in 206 organ(s), highest expression level in mouth mucosa
ExpressionAtlasiK7EQ71 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
SMARTiView protein in SMART
SM00250 PLEC, 1 hit
SUPFAMiSSF75399 SSF75399, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EQ71_HUMAN
AccessioniPrimary (citable) accession number: K7EQ71
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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