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Protein
Submitted name:

Inward rectifier potassium channel 16

Gene

KCNJ16

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei200Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channelUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotationSAAS annotation, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Inward rectifier potassium channel 16Imported
Gene namesi
Name:KCNJ16Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000153822.13
HGNCiHGNC:6262 KCNJ16

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei113 – 135HelicalSequence analysisAdd BLAST23
Transmembranei184 – 209HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153822

PTM / Processingi

Proteomic databases

PRIDEiK7EPW9

Expressioni

Gene expression databases

BgeeiENSG00000153822 Expressed in 141 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiK7EPW9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EPW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00920000149056
OMAiSIFWLIA
OrthoDBiEOG091G08HC

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR008061 K_chnl_inward-rec_Kir5
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF24 PTHR11767:SF24, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01678 KIR5CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

K7EPW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILQKCRKVL TENPNQEIAT SLEFLLLQNS PGSLRAQQRM SYYGSSYHII
60 70 80 90 100
NADAKYPGYP PEHIIAEKRR ARRRLLHKDG SCNVYFKHIF GEWGSYVVDI
110 120 130 140 150
FTTLVDTKWR HMFVIFSLSY ILSWLIFGSV FWLIAFHHGD LLNDPDITPC
160 170 180 190 200
VDNVHSFTGA FLFSLETQTT IGYGYRCVTE ECSVAVLMVI LQSILSCIIN
210 220 230 240 250
TFIIGAALAK MATARKRAQT IRFSYFALIG MRDGKLCLMW RIGDFRPNHV
260 270 280 290 300
VEGTVRAQLL RYTEDSEGRM TMAFKDLKLV NDQIILVTPV TIVHEIDHES
310 320 330 340 350
PLYALDRKAV AKDNFEILVT FIYTGDSTGT SHQSRSSYVP REILWGHRFN
360 370 380 390 400
DVLEVKRKYY KVNCLQFEGS VEVYAPFCSA KQLDWKDQQL HIEKAPPVRE
410 420 430 440 450
SCTSDTKARR RSFSAVAIVS SCENPEETTT SATHEYRETP YQKALLTLNR

ISVESQM
Length:457
Mass (Da):52,400
Last modified:January 9, 2013 - v1
Checksum:iE8D79DADCEB708DD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NPI9KCJ16_HUMAN
Inward rectifier potassium channel ...
KCNJ16
418Annotation score:
K7EJR9K7EJR9_HUMAN
Inward rectifier potassium channel ...
KCNJ16 hCG_1643520
453Annotation score:
K7ELL5K7ELL5_HUMAN
Inward rectifier potassium channel ...
KCNJ16
64Annotation score:
K7EKJ4K7EKJ4_HUMAN
Inward rectifier potassium channel ...
KCNJ16
35Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005208 Genomic DNA No translation available.
KF459700 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000586462; ENSP00000467568; ENSG00000153822
UCSCiuc060jiv.1 human

Similar proteinsi

Entry informationi

Entry nameiK7EPW9_HUMAN
AccessioniPrimary (citable) accession number: K7EPW9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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