Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

ATP-binding cassette sub-family A member 5

Gene

ABCA5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi514 – 521ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette sub-family A member 5Imported
Gene namesi
Name:ABCA5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000154265.15
HGNCiHGNC:35 ABCA5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Transmembranei221 – 242HelicalSequence analysisAdd BLAST22
Transmembranei262 – 291HelicalSequence analysisAdd BLAST30
Transmembranei298 – 321HelicalSequence analysisAdd BLAST24
Transmembranei327 – 348HelicalSequence analysisAdd BLAST22
Transmembranei355 – 376HelicalSequence analysisAdd BLAST22
Transmembranei396 – 417HelicalSequence analysisAdd BLAST22
Transmembranei865 – 886HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154265

PTM / Processingi

Proteomic databases

MaxQBiK7EPM3
PeptideAtlasiK7EPM3
PRIDEiK7EPM3

Expressioni

Gene expression databases

BgeeiENSG00000154265 Expressed in 227 organ(s), highest expression level in intestine
ExpressionAtlasiK7EPM3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EPM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini478 – 713ABC transporterInterPro annotationAdd BLAST236

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00760000118965

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030367 ABCA5
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PTHR19229:SF100 PTHR19229:SF100, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

K7EPM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAIREVGV WRQTRTLLLK NYLIKCRTKK SSVQEILFPL FFLFWLILIS
60 70 80 90 100
MMHPNKKYEE VPNIELNPMD KFTLSNLILG YTPVTNITSS IMQKVSTDHL
110 120 130 140 150
PDVIITEEYT NEKEMLTSSL SKPSNFVGVV FKDSMSYELR FFPDMIPVSS
160 170 180 190 200
IYMDSRAGCS KSCEAAQYWS SGFTVLQASI DAAIIQLKTN VSLWKELEST
210 220 230 240 250
KAVIMGETAV VEIDTFPRGV ILIYLVIAFS PFGYFLAIHI VAEKEKKIKE
260 270 280 290 300
FLKIMGLHDT AFWLSWVLLY TSLIFLMSLL MAVIATASLL FPQSSSIVIF
310 320 330 340 350
LLFFLYGLSS VFFALMLTPL FKKSKHVGIV EFFVTVAFGF IGLMIILIES
360 370 380 390 400
FPKSLVWLFS PFCHCTFVIG IAQVMHLEDF NEGASFSNLT AGPYPLIITI
410 420 430 440 450
IMLTLNSIFY VLLAVYLDQV IPGEFGLRRS SLYFLKPSYW SKSKRNYEEL
460 470 480 490 500
SEGNVNGNIS FSEIIEPVSS EFVGKEAIRI SGIQKTYRKK GENVEALRNL
510 520 530 540 550
SFDIYEGQIT ALLGHSGTGK STLMNILCGL CPPSDGFASI YGHRVSEIDE
560 570 580 590 600
MFEARKMIGI CPQLDIHFDV LTVEENLSIL ASIKGIPANN IIQEVQKVLL
610 620 630 640 650
DLDMQTIKDN QAKKLSGGQK RKLSLGIAVL GNPKILLLDE PTAGMDPCSR
660 670 680 690 700
HIVWNLLKYR KANRVTVFST HFMDEADILA DRKAVISQGM LKCVGSSMFL
710 720 730 740 750
KSKWGIGYRL SMYIDKYCAT ESLSSLVKQH IPGATLLQQN DQQLVYSLPF
760 770 780 790 800
KDMDKFSGLF SALDSHSNLG VISYGVSMTT LEDVFLKLEV EAEIDQADYS
810 820 830 840 850
VFTQQPLEEE MDSKSFDEME QSLLILSETK AALVSTMSLW KQQMYTIAKF
860 870 880 890 900
HFFTLKRESK SVRSVLLLLL IFFTVQIFMF LVHHSFKNAV VPIKLVPDLY
910
FLKPGDKPHK YKTSLLL
Length:917
Mass (Da):103,592
Last modified:January 9, 2013 - v1
Checksum:i37F148C7533DEE25
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8WWZ7ABCA5_HUMAN
ATP-binding cassette sub-family A m...
ABCA5 KIAA1888
1,642Annotation score:
Q6N017Q6N017_HUMAN
ATP-binding cassette sub-family A m...
ABCA5 DKFZp686K07118
431Annotation score:
K7EJW6K7EJW6_HUMAN
ATP-binding cassette sub-family A m...
ABCA5
573Annotation score:
K7EMV2K7EMV2_HUMAN
ATP-binding cassette sub-family A m...
ABCA5
127Annotation score:
A0A075B778A0A075B778_HUMAN
ATP-binding cassette sub-family A m...
ABCA5
250Annotation score:
K7ENF9K7ENF9_HUMAN
ATP-binding cassette sub-family A m...
ABCA5
192Annotation score:
K7EKS9K7EKS9_HUMAN
ATP-binding cassette sub-family A m...
ABCA5
63Annotation score:
K7EQ50K7EQ50_HUMAN
ATP-binding cassette sub-family A m...
ABCA5
38Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei917Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005495 Genomic DNA No translation available.
AC115085 Genomic DNA No translation available.
KF456324 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000593153; ENSP00000467448; ENSG00000154265
UCSCiuc060jho.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005495 Genomic DNA No translation available.
AC115085 Genomic DNA No translation available.
KF456324 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EPM3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiK7EPM3
PeptideAtlasiK7EPM3
PRIDEiK7EPM3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593153; ENSP00000467448; ENSG00000154265
UCSCiuc060jho.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000154265.15
HGNCiHGNC:35 ABCA5
OpenTargetsiENSG00000154265
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00760000118965

Miscellaneous databases

ChiTaRSiABCA5 human

Gene expression databases

BgeeiENSG00000154265 Expressed in 227 organ(s), highest expression level in intestine
ExpressionAtlasiK7EPM3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030367 ABCA5
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PTHR19229:SF100 PTHR19229:SF100, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EPM3_HUMAN
AccessioniPrimary (citable) accession number: K7EPM3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again