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Protein

Cysteine protease

Gene

ATG4D

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation
Biological processAutophagyUniRule annotationSAAS annotation, Protein transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteaseUniRule annotation (EC:3.4.22.-UniRule annotation)
Gene namesi
Name:ATG4DImported
ORF Names:hCG_28499Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130734.9
HGNCiHGNC:20789 ATG4D

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130734

PTM / Processingi

Proteomic databases

PeptideAtlasiK7EPJ0
PRIDEiK7EPJ0

Expressioni

Gene expression databases

BgeeiENSG00000130734 Expressed in 197 organ(s), highest expression level in testis
ExpressionAtlasiK7EPJ0 baseline and differential

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C54 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2674 Eukaryota
ENOG410XPQ0 LUCA
GeneTreeiENSGT00530000063000

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR005078 Peptidase_C54
PANTHERiPTHR22624 PTHR22624, 1 hit
PfamiView protein in Pfam
PF03416 Peptidase_C54, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

K7EPJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSVSPAAAQ YRSSSPEDAR RRPEARRPRG PRGPDPNGLG PSGASGPALG
60 70 80 90 100
SPGAGPSEPD EVDKFKAKFL TAWNNVKYGW VVKSRTSFSK ISSIHLCGRR
110 120 130 140 150
YRFEGEGDIQ RFQRDFVSRL WLTYRRDFPP LPGGCLTSDC GWGCMLRSGQ
160 170 180 190 200
MMLAQGLLLH FLPRGKPWRA APTSPAWWCT FLRTAQCTRR MWHAWWPGQT
210 220
PQPSGSLWSS WCPCDWVARL STPCMCPA
Length:228
Mass (Da):25,517
Last modified:January 9, 2013 - v1
Checksum:i9B8B6510B01BE3E4
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86TL0ATG4D_HUMAN
Cysteine protease ATG4D
ATG4D APG4D, AUTL4
474Annotation score:
K7EJA5K7EJA5_HUMAN
Cysteine protease
ATG4D
177Annotation score:
K7ERK1K7ERK1_HUMAN
Cysteine protease
ATG4D
334Annotation score:
K7EN30K7EN30_HUMAN
Cysteine protease
ATG4D
177Annotation score:
K7EQ67K7EQ67_HUMAN
Cysteine protease
ATG4D
99Annotation score:
K7ESM7K7ESM7_HUMAN
Cysteine protease
ATG4D
203Annotation score:
K7EP43K7EP43_HUMAN
Cysteine protease
ATG4D
209Annotation score:
K7EMB9K7EMB9_HUMAN
Cysteine protease
ATG4D
67Annotation score:
K7EKP6K7EKP6_HUMAN
Cysteine protease ATG4D
ATG4D
120Annotation score:
K7EQN3K7EQN3_HUMAN
Cysteine protease ATG4D
ATG4D
160Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011461 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84117.1
UniGeneiHs.512799

Genome annotation databases

EnsembliENST00000588667; ENSP00000467407; ENSG00000130734
UCSCiuc060tjc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011461 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84117.1
UniGeneiHs.512799

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiK7EPJ0
PRIDEiK7EPJ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588667; ENSP00000467407; ENSG00000130734
UCSCiuc060tjc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000130734.9
HGNCiHGNC:20789 ATG4D
OpenTargetsiENSG00000130734
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2674 Eukaryota
ENOG410XPQ0 LUCA
GeneTreeiENSGT00530000063000

Miscellaneous databases

ChiTaRSiATG4D human

Gene expression databases

BgeeiENSG00000130734 Expressed in 197 organ(s), highest expression level in testis
ExpressionAtlasiK7EPJ0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR005078 Peptidase_C54
PANTHERiPTHR22624 PTHR22624, 1 hit
PfamiView protein in Pfam
PF03416 Peptidase_C54, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EPJ0_HUMAN
AccessioniPrimary (citable) accession number: K7EPJ0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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