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Protein
Submitted name:

Transducin-like enhancer protein 2

Gene

TLE2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Transducin-like enhancer protein 2Imported
Gene namesi
Name:TLE2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000065717.14
HGNCiHGNC:11838 TLE2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065717

PTM / Processingi

Proteomic databases

PeptideAtlasiK7EPF3
PRIDEiK7EPF3

Expressioni

Gene expression databases

BgeeiENSG00000065717 Expressed in 232 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiK7EPF3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EPF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 99TLE_NInterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili25 – 52Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465

Family and domain databases

InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

K7EPF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA
60 70 80 90 100
SEKTEMQRHY VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQESA
110 120 130 140
SPSPPESLVE EERPSGPGGG GKQRADEKEP SGPYESDEDK
Length:140
Mass (Da):15,998
Last modified:January 9, 2013 - v1
Checksum:i846918FD7F319EBC
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q04725TLE2_HUMAN
Transducin-like enhancer protein 2
TLE2
743Annotation score:
K7EMK7K7EMK7_HUMAN
Transducin-like enhancer protein 2
TLE2
744Annotation score:
K7EJR7K7EJR7_HUMAN
Transducin-like enhancer protein 2
TLE2
280Annotation score:
K7ESD8K7ESD8_HUMAN
Transducin-like enhancer protein 2
TLE2
178Annotation score:
K7EPD4K7EPD4_HUMAN
Transducin-like enhancer protein 2
TLE2
131Annotation score:
K7EK93K7EK93_HUMAN
Transducin-like enhancer protein 2
TLE2
119Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei140Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007766 Genomic DNA No translation available.
AC011549 Genomic DNA No translation available.
AC093053 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000587137; ENSP00000467358; ENSG00000065717
UCSCiuc060rno.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007766 Genomic DNA No translation available.
AC011549 Genomic DNA No translation available.
AC093053 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EPF3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiK7EPF3
PRIDEiK7EPF3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587137; ENSP00000467358; ENSG00000065717
UCSCiuc060rno.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000065717.14
HGNCiHGNC:11838 TLE2
OpenTargetsiENSG00000065717
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465

Miscellaneous databases

ChiTaRSiTLE2 human

Gene expression databases

BgeeiENSG00000065717 Expressed in 232 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiK7EPF3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EPF3_HUMAN
AccessioniPrimary (citable) accession number: K7EPF3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: November 7, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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