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Protein
Submitted name:

Guanine nucleotide-binding protein G(olf) subunit alpha

Gene

GNAL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Guanine nucleotide-binding protein G(olf) subunit alphaImported
Gene namesi
Name:GNALImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000141404.15
HGNCiHGNC:4388 GNAL

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141404

PTM / Processingi

Proteomic databases

MaxQBiK7EPE2
PeptideAtlasiK7EPE2
PRIDEiK7EPE2

Expressioni

Gene expression databases

BgeeiENSG00000141404 Expressed in 221 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiK7EPE2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EPE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0099 Eukaryota
ENOG410XPC4 LUCA
GeneTreeiENSGT00910000144108

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00443 GPROTEINAS
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

K7EPE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRILHVNGFN PEEKKQKILD IRKNVKDAIV TIVSAMSTII PPVPLANPEN
60 70 80 90 100
QFRSDYIKSI APITDFEYSQ EFFDHVKKLW DDEGVKACFE RSNEYQLIDC
110 120 130 140 150
AQYFLERIDS VSLVDYTPTD QDLLRCRVLT SGIFETRFQV DKVNFHMFDV
160 170
GGQRDERRKW IQCFNDVTAI IYVAACSSY
Length:179
Mass (Da):20,876
Last modified:January 9, 2013 - v1
Checksum:iD2768B00F95C05B1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P38405GNAL_HUMAN
Guanine nucleotide-binding protein ...
GNAL
381Annotation score:
K7EQ80K7EQ80_HUMAN
Guanine nucleotide-binding protein ...
GNAL
145Annotation score:
K7EMY6K7EMY6_HUMAN
Guanine nucleotide-binding protein ...
GNAL
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei179Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001120 Genomic DNA No translation available.
AP001269 Genomic DNA No translation available.
AP005137 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000585642; ENSP00000467345; ENSG00000141404
UCSCiuc060nki.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001120 Genomic DNA No translation available.
AP001269 Genomic DNA No translation available.
AP005137 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EPE2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiK7EPE2
PeptideAtlasiK7EPE2
PRIDEiK7EPE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585642; ENSP00000467345; ENSG00000141404
UCSCiuc060nki.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000141404.15
HGNCiHGNC:4388 GNAL
OpenTargetsiENSG00000141404
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0099 Eukaryota
ENOG410XPC4 LUCA
GeneTreeiENSGT00910000144108

Miscellaneous databases

ChiTaRSiGNAL human

Gene expression databases

BgeeiENSG00000141404 Expressed in 221 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiK7EPE2 baseline and differential

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00443 GPROTEINAS
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EPE2_HUMAN
AccessioniPrimary (citable) accession number: K7EPE2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: November 7, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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