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Protein

Claudin

Gene

CLDN7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:CLDN7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181885.18
HGNCiHGNC:2049 CLDN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 96HelicalUniRule annotationAdd BLAST27

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181885

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500390083925 – 129ClaudinSequence analysisAdd BLAST105

Proteomic databases

EPDiK7EP40
MaxQBiK7EP40
PeptideAtlasiK7EP40
PRIDEiK7EP40

Expressioni

Gene expression databases

BgeeiENSG00000181885 Expressed in 143 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiK7EP40 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EP40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IHPN Eukaryota
ENOG4111GPP LUCA
GeneTreeiENSGT00760000118928

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003552 Claudin7
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01381 CLAUDIN7
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

K7EP40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL
60 70 80 90 100
WMDCVTQSTG MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM
110 120
GMKCTRCGGD DKVKKARIAM GGGIIFIVA
Length:129
Mass (Da):13,649
Last modified:January 9, 2013 - v1
Checksum:iFEAF5880095EF870
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95471CLD7_HUMAN
Claudin-7
CLDN7 CEPTRL2, CPETRL2
211Annotation score:
F5H496F5H496_HUMAN
Claudin
CLDN7
145Annotation score:
I3L3X1I3L3X1_HUMAN
Claudin
CLDN7
193Annotation score:
K7EL87K7EL87_HUMAN
Claudin
CLDN7
140Annotation score:
I3L3L6I3L3L6_HUMAN
Claudin-7
CLDN7
99Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei129Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003688 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000571932; ENSP00000467220; ENSG00000181885
UCSCiuc060alv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003688 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EP40
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiK7EP40
MaxQBiK7EP40
PeptideAtlasiK7EP40
PRIDEiK7EP40

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000571932; ENSP00000467220; ENSG00000181885
UCSCiuc060alv.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000181885.18
HGNCiHGNC:2049 CLDN7
OpenTargetsiENSG00000181885
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHPN Eukaryota
ENOG4111GPP LUCA
GeneTreeiENSGT00760000118928

Miscellaneous databases

ChiTaRSiCLDN7 human

Gene expression databases

BgeeiENSG00000181885 Expressed in 143 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiK7EP40 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003552 Claudin7
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01381 CLAUDIN7
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EP40_HUMAN
AccessioniPrimary (citable) accession number: K7EP40
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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