UniProtKB - K7ENS6 (K7ENS6_HUMAN)
Protein
Submitted name:
E3 ubiquitin-protein ligase NEDD4-like
Gene
NEDD4L
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: E3 ubiquitin-protein ligase NEDD4-likeImported |
Gene namesi | Name:NEDD4LImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000049759.16 |
HGNCi | HGNC:7728, NEDD4L |
Expressioni
Gene expression databases
Bgeei | ENSG00000049759, Expressed in forebrain and 225 other tissues |
ExpressionAtlasi | K7ENS6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 72 – 105 | WWInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 81 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 101 – 150 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 39 – 55 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 101 – 119 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 120 – 140 | PolyampholyteSequence analysisAdd BLAST | 21 |
Phylogenomic databases
GeneTreei | ENSGT00940000156873 |
HOGENOMi | CLU_1744660_0_0_1 |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR035892, C2_domain_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
K7ENS6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPYTFKDF LLRPRSHKSR VKGFLRLKMA YMPKNGGQDE ENSDQRDDME
60 70 80 90 100
HGWEVVDSND SASQHQEELP PPPLPPGWEE KVDNLGRTYY VNHNNRTTQW
110 120 130 140 150
HRPSLMDVSS ESDNNIRQIN QEAAHRRFRS RRHISEDLEP EPSEGGDVPE
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96PU5 | NED4L_HUMAN | E3 ubiquitin-protein ligase NEDD4-l... | NEDD4L KIAA0439, NEDL3 | 975 | Annotation score: | ||
K7ERN1 | K7ERN1_HUMAN | HECT-type E3 ubiquitin transferase | NEDD4L | 639 | Annotation score: | ||
A0A1B0GVY1 | A0A1B0GVY1_HUMAN | HECT-type E3 ubiquitin transferase | NEDD4L | 1,254 | Annotation score: | ||
K7EKL1 | K7EKL1_HUMAN | E3 ubiquitin-protein ligase NEDD4-l... | NEDD4L | 106 | Annotation score: | ||
A0A087WVI6 | A0A087WVI6_HUMAN | E3 ubiquitin-protein ligase NEDD4-l... | NEDD4L | 20 | Annotation score: | ||
K7EN51 | K7EN51_HUMAN | E3 ubiquitin-protein ligase NEDD4-l... | NEDD4L | 35 | Annotation score: | ||
K7EQC5 | K7EQC5_HUMAN | E3 ubiquitin-protein ligase NEDD4-l... | NEDD4L | 15 | Annotation score: | ||
A0A140TA85 | A0A140TA85_HUMAN | E3 ubiquitin-protein ligase NEDD4-l... | NEDD4L | 10 | Annotation score: | ||
A0A6Q8PFI7 | A0A6Q8PFI7_HUMAN | E3 ubiquitin-protein ligase NEDD4-l... | NEDD4L | 948 | Annotation score: | ||
A0A6Q8PG51 | A0A6Q8PG51_HUMAN | E3 ubiquitin-protein ligase NEDD4-l... | NEDD4L | 863 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 150 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015988 Genomic DNA No translation available. AC090236 Genomic DNA No translation available. AC107896 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000586268; ENSP00000467072; ENSG00000049759 |
UCSCi | uc060poh.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015988 Genomic DNA No translation available. AC090236 Genomic DNA No translation available. AC107896 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | K7ENS6 |
Protocols and materials databases
Antibodypediai | 5421, 236 antibodies |
Genome annotation databases
Ensembli | ENST00000586268; ENSP00000467072; ENSG00000049759 |
UCSCi | uc060poh.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000049759.16 |
HGNCi | HGNC:7728, NEDD4L |
OpenTargetsi | ENSG00000049759 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156873 |
HOGENOMi | CLU_1744660_0_0_1 |
Miscellaneous databases
ChiTaRSi | NEDD4L, human |
Gene expression databases
Bgeei | ENSG00000049759, Expressed in forebrain and 225 other tissues |
ExpressionAtlasi | K7ENS6, baseline and differential |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR035892, C2_domain_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K7ENS6_HUMAN | |
Accessioni | K7ENS6Primary (citable) accession number: K7ENS6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | January 9, 2013 | |
Last modified: | October 7, 2020 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |