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Entry version 37 (31 Jul 2019)
Sequence version 2 (05 Oct 2016)
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Protein
Submitted name:

Fas-binding factor 1

Gene

FBF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fas-binding factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24674 FBF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000188878

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
K7ENL6

PeptideAtlas

More...
PeptideAtlasi
K7ENL6

PRoteomics IDEntifications database

More...
PRIDEi
K7ENL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188878 Expressed in 86 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
K7ENL6 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni102 – 211DisorderedSequence analysisAdd BLAST110
Regioni224 – 557DisorderedSequence analysisAdd BLAST334
Regioni1076 – 1099DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili596 – 630Sequence analysisAdd BLAST35
Coiled coili646 – 688Sequence analysisAdd BLAST43
Coiled coili693 – 713Sequence analysisAdd BLAST21
Coiled coili715 – 739Sequence analysisAdd BLAST25
Coiled coili786 – 813Sequence analysisAdd BLAST28
Coiled coili861 – 881Sequence analysisAdd BLAST21
Coiled coili932 – 983Sequence analysisAdd BLAST52
Coiled coili1002 – 1043Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi175 – 199PolarSequence analysisAdd BLAST25
Compositional biasi270 – 293PolyampholyteSequence analysisAdd BLAST24
Compositional biasi304 – 323PolarSequence analysisAdd BLAST20
Compositional biasi357 – 374PolyampholyteSequence analysisAdd BLAST18
Compositional biasi385 – 406Pro-richSequence analysisAdd BLAST22
Compositional biasi425 – 450PolyampholyteSequence analysisAdd BLAST26
Compositional biasi471 – 488PolarSequence analysisAdd BLAST18
Compositional biasi539 – 553PolarSequence analysisAdd BLAST15
Compositional biasi1076 – 1097PolarSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFRT Eukaryota
ENOG4111RN4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00720000108861

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKASYNM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
K7ENL6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033561 FBF1

The PANTHER Classification System

More...
PANTHERi
PTHR33689 PTHR33689, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

K7ENL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
APKTKKGCKG SIDDFLGDLL GDDMTLPEKP VKLASHTRDT TGVSQMFPSS
60 70 80 90 100
KARTKSLLGD DVFSTMAGLE EADAEVSGIS EADPQALLQA MKDLDGMDAD
110 120 130 140 150
ILGLKKSNSA PSKKAAKDPG KGELPNHPKP AGGAIPTKKS LPSPSSSGHQ
160 170 180 190 200
NRRFSSEDLE DPLRGLLSYD EGGITKQPPV TQSKTASDKS PSTVRDQGPS
210 220 230 240 250
IPLTPGDTPI RKKEELLFDD GDDIMATLGF GDSPKAEKRQ IGDQEGPRPA
260 270 280 290 300
RSTLDELLGR GMATKLLARP GTGEHREFKL DKKYQRPQDS EDMWGDEDFT
310 320 330 340 350
FGAYQPTVVS SEGRQSRRQS VSRFFADSGA DPKGEPGSKQ SPPMASSPIQ
360 370 380 390 400
PRKGGADWLG LKDEDLDLFP ASPTREAHRE SSVPVTPSVP PPASQHSTPA
410 420 430 440 450
GLPPSRAKPP TEGAGSPAKA SQASKLRASK EEKEDWLSHA LSRKKSQGLA
460 470 480 490 500
REQHAGTSEG LHLAGTAGHP PSGSQPLTST QGLEHAAAGG SSGTTARERP
510 520 530 540 550
CVRPGVSGSP VTQNHAASAL PTGSPKRGTA PGDLSATEPA TCFPSTQKPT
560 570 580 590 600
EPSVPVQPLL PESLARSLLP STEYQKQLLA AQVQLQCSPA ELQAELLHSQ
610 620 630 640 650
ARLAELEAQV RKLELERAQH ELLLGSLQQQ HQADLELIES AHRSRIKVLE
660 670 680 690 700
TSYQQREERL RRENEELSAR YLSQCQEAEQ ARAELTAQHQ RRLAAIAQEK
710 720 730 740 750
DQEMERLREL QRASILDMRR DHEEQLQRLK LLKDREVDAA TSATSHTRSL
760 770 780 790 800
NSIIHQMEKF SSSLHELSSR VEASHLTTSQ ERELGIRQRD EQLRALQERL
810 820 830 840 850
GQQQRDMEEE RSRQQEVIGK MEARLNEQSR LLEQERWRVT AEQSKAESMQ
860 870 880 890 900
RALEEQRKVT AQQMAMERAE LERAKSALLE EQKSVMLKCG EERRRLAAEW
910 920 930 940 950
AEFSAQQKLS KERAEREAER ALQVDTQREG TLISLAKEQA ELKIRASELR
960 970 980 990 1000
AEEKQLAAER AALEQERQEL RLEKERINAT ALRVKLRAEE VESMSKVASE
1010 1020 1030 1040 1050
KYEEGERALR EAQQVQAEQQ ARLQAVQQQQ ERLRKQEQHM HQEHLSLAQQ
1060 1070 1080 1090 1100
RLQLDRARQD LPSSLVGLFP RAQGPAASSQ SALMPPAPTT RWCSQPPTGL
1110 1120 1130 1140
DPSPLHLHAR LALLRHMAEQ DRDFLENEQF FLETLKKGSY NLTSHSA
Length:1,147
Mass (Da):126,910
Last modified:October 5, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EA333A1177EAF80
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TES7FBF1_HUMAN
Fas-binding factor 1
FBF1 ALB, KIAA1863
1,133Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2E4A0A0R4J2E4_HUMAN
Fas-binding factor 1
FBF1
1,092Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPQ1K7EPQ1_HUMAN
Fas-binding factor 1
FBF1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESG2K7ESG2_HUMAN
Fas-binding factor 1
FBF1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL64K7EL64_HUMAN
Fas-binding factor 1
FBF1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPW3U3KPW3_HUMAN
Fas-binding factor 1
FBF1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC087289 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000592193; ENSP00000467004; ENSG00000188878

UCSC genome browser

More...
UCSCi
uc060kfj.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087289 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiK7ENL6
PeptideAtlasiK7ENL6
PRIDEiK7ENL6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000592193; ENSP00000467004; ENSG00000188878
UCSCiuc060kfj.1 human

Organism-specific databases

HGNCiHGNC:24674 FBF1
OpenTargetsiENSG00000188878

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFRT Eukaryota
ENOG4111RN4 LUCA
GeneTreeiENSGT00720000108861
OMAiKKASYNM
PhylomeDBiK7ENL6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FBF1 human

Gene expression databases

BgeeiENSG00000188878 Expressed in 86 organ(s), highest expression level in right testis
ExpressionAtlasiK7ENL6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR033561 FBF1
PANTHERiPTHR33689 PTHR33689, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7ENL6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7ENL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: October 5, 2016
Last modified: July 31, 2019
This is version 37 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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