UniProtKB - K7EMQ3 (K7EMQ3_HUMAN)
Protein
Submitted name:
Dynamin-2
Gene
DNM2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: InterPro
GO - Biological processi
- endocytosis Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Dynamin-2Imported |
Gene namesi | Name:DNM2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2974, DNM2 |
VEuPathDBi | HostDB:ENSG00000079805.16 |
Subcellular locationi
Cytoskeleton
- microtubule Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000079805, Expressed in cortex of kidney and 198 other tissues |
ExpressionAtlasi | K7EMQ3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 46 | Dynamin-type GInterPro annotationAdd BLAST | 46 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 49 – 69 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155764 |
HOGENOMi | CLU_008964_3_3_1 |
Family and domain databases
InterProi | View protein in InterPro IPR027188, DNM2 IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit PTHR11566:SF23, PTHR11566:SF23, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51718, G_DYNAMIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
K7EMQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RAALAAERKF FLSHPAYRHM ADRMGTPHLQ KTLNQQLTNH IRESLPALRS
60 70 80 90 100
KLQSQLLSLE KEVEEYKNFR PDDPTRKTKA LLQMVQQFGV DFEKRIEGSG
110 120 130 140 150
DQVDTLELSG GARINRIFHE RFPFELVKME FDEKDLRREI SYAIKNIHGV
160 170 180 190 200
RTGLFTPDMA FEAIVKKQIV KLKEPSLKCV DLVVSELATV IKKCAEKLSS
210 220 230 240 250
YPRLREETER IVTTYIRERE GRTKDQILLL IDIEQSYINT NHEDFIGFAN
260 270 280
CYYTEQLVTC AQQRSTQLNK KRAIPNQVIR RGWLTINNI
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP50570 | DYN2_HUMAN | Dynamin-2 | DNM2 DYN2 | 870 | Annotation score: | ||
K7ENE7 | K7ENE7_HUMAN | Dynamin-2 | DNM2 | 137 | Annotation score: | ||
K7EPK9 | K7EPK9_HUMAN | Dynamin-2 | DNM2 | 50 | Annotation score: | ||
K7EMR9 | K7EMR9_HUMAN | Dynamin-2 | DNM2 | 169 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 289 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007229 Genomic DNA No translation available. AC011475 Genomic DNA No translation available. AC011552 Genomic DNA No translation available. AC011554 Genomic DNA No translation available. AC112707 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000587830; ENSP00000466603; ENSG00000079805 |
UCSCi | uc060tmf.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007229 Genomic DNA No translation available. AC011475 Genomic DNA No translation available. AC011552 Genomic DNA No translation available. AC011554 Genomic DNA No translation available. AC112707 Genomic DNA No translation available. |
3D structure databases
SMRi | K7EMQ3 |
ModBasei | Search... |
Proteomic databases
MaxQBi | K7EMQ3 |
PeptideAtlasi | K7EMQ3 |
PRIDEi | K7EMQ3 |
Protocols and materials databases
Antibodypediai | 25505, 225 antibodies |
Genome annotation databases
Ensembli | ENST00000587830; ENSP00000466603; ENSG00000079805 |
UCSCi | uc060tmf.1, human |
Organism-specific databases
HGNCi | HGNC:2974, DNM2 |
OpenTargetsi | ENSG00000079805 |
VEuPathDBi | HostDB:ENSG00000079805.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155764 |
HOGENOMi | CLU_008964_3_3_1 |
Miscellaneous databases
ChiTaRSi | DNM2, human |
Gene expression databases
Bgeei | ENSG00000079805, Expressed in cortex of kidney and 198 other tissues |
ExpressionAtlasi | K7EMQ3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR027188, DNM2 IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit PTHR11566:SF23, PTHR11566:SF23, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51718, G_DYNAMIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K7EMQ3_HUMAN | |
Accessioni | K7EMQ3Primary (citable) accession number: K7EMQ3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | September 18, 2013 | |
Last modified: | February 10, 2021 | |
This is version 50 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |