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Protein
Submitted name:

Serine/threonine-protein kinase Nek8

Gene

NEK8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase Nek8Imported
Gene namesi
Name:NEK8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000160602.13
HGNCiHGNC:13387 NEK8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160602

PTM / Processingi

Proteomic databases

PeptideAtlasiK7EMF0
PRIDEiK7EMF0

Expressioni

Gene expression databases

BgeeiENSG00000160602 Expressed in 156 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiK7EMF0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EMF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 84Protein kinaseInterPro annotationAdd BLAST84
Repeati166 – 204RCC1PROSITE-ProRule annotationAdd BLAST39

Phylogenomic databases

GeneTreeiENSGT00760000118997

Family and domain databases

Gene3Di2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50012 RCC1_3, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

K7EMF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XEGKPYNQKS DIWALGCVLY ELASLKRAFE AANLPALVLK IMSGTFAPIS
60 70 80 90 100
DRYSPELRQL VLSLLSLEPA QRPPLSHIMA QPLCIRALLN LHTDVGSVRM
110 120 130 140 150
RRPVQGQRAV LGGRVWAPSG STGGPHLSCR AEKSVAPSNT GSRTTSVRCR
160 170 180 190 200
GIPRGPVRPA IPPPLSSVYA WGGGLGTPLR LPMLNTEVVQ VAAGRTQKAG
210 220 230 240 250
VTRSGRLILW EAPPLGAGGG SLLPGAVEQP QPQFISRFLE GQSGVTIKHV
260
ACGDFFTACL T
Length:261
Mass (Da):27,736
Last modified:January 9, 2013 - v1
Checksum:iAAB0DC0ADC00BD35
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86SG6NEK8_HUMAN
Serine/threonine-protein kinase Nek...
NEK8 JCK, NEK12A
692Annotation score:
K7EL04K7EL04_HUMAN
Serine/threonine-protein kinase Nek...
NEK8
460Annotation score:
K7EPD3K7EPD3_HUMAN
Serine/threonine-protein kinase Nek...
NEK8
165Annotation score:
K7END4K7END4_HUMAN
Serine/threonine-protein kinase Nek...
NEK8
167Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei261Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010761 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000592510; ENSP00000466476; ENSG00000160602
UCSCiuc060dee.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010761 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EMF0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiK7EMF0
PRIDEiK7EMF0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000592510; ENSP00000466476; ENSG00000160602
UCSCiuc060dee.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000160602.13
HGNCiHGNC:13387 NEK8
OpenTargetsiENSG00000160602
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118997

Gene expression databases

BgeeiENSG00000160602 Expressed in 156 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiK7EMF0 baseline and differential

Family and domain databases

Gene3Di2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50012 RCC1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7EMF0_HUMAN
AccessioniPrimary (citable) accession number: K7EMF0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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