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UniProtKB - K7EMA2 (K7EMA2_HUMAN)
Protein
Submitted name:
Beclin-1
Gene
BECN1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- autophagy Source: UniProtKB-KW
- cellular response to stress Source: UniProt
- endocytosis Source: InterPro
- regulation of cytokinesis Source: InterPro
Keywordsi
Biological process | AutophagyARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Beclin-1 |
Gene namesi | Name:BECN1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1034, BECN1 |
VEuPathDBi | HostDB:ENSG00000126581 |
Expressioni
Gene expression databases
Bgeei | ENSG00000126581, Expressed in frontal cortex and 243 other tissues |
ExpressionAtlasi | K7EMA2, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 53 | APG6InterPro annotationAdd BLAST | 52 | |
Domaini | 52 – 101 | APG6InterPro annotationAdd BLAST | 50 |
Sequence similaritiesi
Belongs to the beclin family.ARBA annotation
Keywords - Domaini
Coiled coilARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000008164 |
HOGENOMi | CLU_2242633_0_0_1 |
Family and domain databases
Gene3Di | 1.10.418.40, 2 hits |
InterProi | View protein in InterPro IPR007243, Atg6/Beclin IPR038274, Atg6/Beclin_C_sf IPR040455, Atg6_BARA IPR032913, BECN1 |
PANTHERi | PTHR12768, PTHR12768, 2 hits PTHR12768:SF6, PTHR12768:SF6, 2 hits |
Pfami | View protein in Pfam PF04111, APG6, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
K7EMA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XHSGQFGTIN NFRLGRLPSV PVEWNEINAA WGQTVLLLHA LANKMGLKFQ
60 70 80 90 100
RMDVEKGKIE DTGGSGGSYS IKTQFNSEEQ WTKALKFMLT NLKWGLAWVS
SQFYNK
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14457 | BECN1_HUMAN | Beclin-1 | BECN1 GT197 | 450 | Annotation score: | ||
E7EV84 | E7EV84_HUMAN | Beclin-1 | BECN1 | 279 | Annotation score: | ||
K7ER46 | K7ER46_HUMAN | Beclin-1 | BECN1 | 132 | Annotation score: | ||
K7ELY9 | K7ELY9_HUMAN | Beclin-1 | BECN1 | 229 | Annotation score: | ||
K7EN35 | K7EN35_HUMAN | Beclin-1 | BECN1 | 176 | Annotation score: | ||
K7ERY0 | K7ERY0_HUMAN | Beclin-1 | BECN1 | 72 | Annotation score: | ||
K7EKK2 | K7EKK2_HUMAN | Beclin-1 | BECN1 | 76 | Annotation score: | ||
K7EQQ7 | K7EQQ7_HUMAN | Beclin-1 | BECN1 | 59 | Annotation score: | ||
A0A087WVZ2 | A0A087WVZ2_HUMAN | Beclin-1 | BECN1 | 20 | Annotation score: | ||
K7EL88 | K7EL88_HUMAN | Beclin-1 | BECN1 | 55 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016889 Genomic DNA No translation available. KF511232 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000588276.5; ENSP00000466419.1; ENSG00000126581.13 |
UCSCi | uc060fnv.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016889 Genomic DNA No translation available. KF511232 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | K7EMA2 |
PeptideAtlasi | K7EMA2 |
Protocols and materials databases
Antibodypediai | 4116, 1612 antibodies from 46 providers |
Genome annotation databases
Ensembli | ENST00000588276.5; ENSP00000466419.1; ENSG00000126581.13 |
UCSCi | uc060fnv.1, human |
Organism-specific databases
HGNCi | HGNC:1034, BECN1 |
OpenTargetsi | ENSG00000126581 |
VEuPathDBi | HostDB:ENSG00000126581 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000008164 |
HOGENOMi | CLU_2242633_0_0_1 |
Miscellaneous databases
ChiTaRSi | BECN1, human |
Gene expression databases
Bgeei | ENSG00000126581, Expressed in frontal cortex and 243 other tissues |
ExpressionAtlasi | K7EMA2, baseline and differential |
Family and domain databases
Gene3Di | 1.10.418.40, 2 hits |
InterProi | View protein in InterPro IPR007243, Atg6/Beclin IPR038274, Atg6/Beclin_C_sf IPR040455, Atg6_BARA IPR032913, BECN1 |
PANTHERi | PTHR12768, PTHR12768, 2 hits PTHR12768:SF6, PTHR12768:SF6, 2 hits |
Pfami | View protein in Pfam PF04111, APG6, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | K7EMA2_HUMAN | |
Accessioni | K7EMA2Primary (citable) accession number: K7EMA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | January 9, 2013 | |
Last modified: | May 25, 2022 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |