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Entry version 48 (12 Aug 2020)
Sequence version 1 (09 Jan 2013)
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Protein
Submitted name:

Dynein heavy chain 17, axonemal

Gene

DNAH17

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dynein heavy chain 17, axonemalImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187775.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2946, DNAH17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, CiliumARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000187775

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
K7ELN3

PRoteomics IDEntifications database

More...
PRIDEi
K7ELN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187775, Expressed in C1 segment of cervical spinal cord and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
K7ELN3, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 231AAA_8InterPro annotationAdd BLAST196
Domaini244 – 587MTInterPro annotationAdd BLAST344
Domaini614 – 831AAA_9InterPro annotationAdd BLAST218
Domaini1072 – 1199Dynein_heavyInterPro annotationAdd BLAST128
Domaini1201 – 1360AAA_lid_11InterPro annotationAdd BLAST160
Domaini1368 – 1508Dynein_CInterPro annotationAdd BLAST141

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili236 – 287Sequence analysisAdd BLAST52
Coiled coili459 – 507Sequence analysisAdd BLAST49
Coiled coili775 – 795Sequence analysisAdd BLAST21
Coiled coili831 – 851Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_1_1_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041228, Dynein_C
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676, PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

K7ELN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XEGRTEGEGK PGPARAVPAE TACVTSGTRL GSRIRNLQID LAAQYIKAAV
60 70 80 90 100
KNVPSVFLMT DSQVAEEQFL VLINDLLASG EIPGLFMEDE VENIISSMRP
110 120 130 140 150
QVKSLGMNDT RETCWKFFIE KVRRQLKVIL CFSPVGSVLR VRARKFPAVV
160 170 180 190 200
NCTAIDWFHE WPEDALVSVS ARFLEETEGI PWEVKASISF FMSYVHTTVN
210 220 230 240 250
EMSRVYLATE RRYNYTTPKT FLEQIKLYQN LLAKKRTELV AKIERLENGL
260 270 280 290 300
MKLQSTASQV DDLKAKLAIQ EAELKQKNES ADQLIQVVGI EAEKVSKEKA
310 320 330 340 350
IADQEEVKVE VINKNVTEKQ KACETDLAKA EPALLAAQEA LDTLNKNNLT
360 370 380 390 400
ELKSFGSPPD AVVNVTAAVM ILTAPGGKIP KDKSWKAAKI MMGKVDTFLD
410 420 430 440 450
SLKKFDKEHI PEACLKAFKP YQGNPTFDPE FIRSKSTAAA GLCSWCINIV
460 470 480 490 500
RFYEVYCDVA PKRQALEEAN AELAEAQEKL SRIKNKIAEL NANLSNLTSA
510 520 530 540 550
FEKATAEKIK CQQEADATNR VILLANRLVG GLASENIRWA ESVENFRSQG
560 570 580 590 600
VTLCGDVLLI SAFVSYVGYF TKKYRNELME KFWIPYIHNL KVPIPITNGL
610 620 630 640 650
DPLSLLTDDA DVATWNNQGL PSDRMSTENA TILGNTERWP LIVDAQLQGI
660 670 680 690 700
KWIKNKYRSE LKAIRLGQKS YLDVIEQAIS EGDTLLIENI GETVDPVLDP
710 720 730 740 750
LLGRNTIKKG KYIKIGDKEV EYHPKFRLIL HTKYFNPHYK PEMQAQCTLI
760 770 780 790 800
NFLVTRDGLE DQLLAAVVAK ERPDLEQLKA NLTKSQNEFK IVLKELEDSL
810 820 830 840 850
LARLSAASGN FLGDTALVEN LETTKHTASE IEEKVVEAKI TEVKINEARE
860 870 880 890 900
NYRPAAERAS LLYFILNDLN KINPVYQFSL KAFNVVFEKA IQRTTPANEV
910 920 930 940 950
KQRVINLTDE ITYSVYMYTA RGLFERDKLI FLAQVTFQVL SMKKELNPVE
960 970 980 990 1000
LDFLLRFPFK AGVVSPVDFL QHQGWGGIKA LSEMDEFKNL DSDIEGSAKR
1010 1020 1030 1040 1050
WKKLVESEAP EKEIFPKEWK NKTALQKLCM VRCLRPDRMT YAIKNFVEEK
1060 1070 1080 1090 1100
MGSKFVEGRS VEFSKSYEES SPSTSIFFIL SPGVDPLKDV EALGKKLGFT
1110 1120 1130 1140 1150
IDNGKLHNVS LGQGQEVVAE NALDVAAEKG HWVILQNIHL VARWLGTLDK
1160 1170 1180 1190 1200
KLEHYSTGSH EDYRVFISAE PAPSPETHII PQGILENAIK ITNEPPTGMH
1210 1220 1230 1240 1250
ANLHKALDLF TQDTLEMCTK EMEFKCMLFA LCYFHAVVAE RRKFGAQGWN
1260 1270 1280 1290 1300
RSYPFNNGDL TISINVLYNY LEANPKVPWD DLRYLFGEIM YGGHITDDWD
1310 1320 1330 1340 1350
RRLCRTYLAE YIRTEMLEGD VLLAPGFQIP PNLDYKGYHE YIDENLPPES
1360 1370 1380 1390 1400
PYLYGLHPNA EIGFLTVTSE KLFRTVLEMQ PKETDSGAGT GVSREEKVKA
1410 1420 1430 1440 1450
VLDDILEKIP ETFNMAEIMA KAAEKTPYVV VAFQECERMN ILTNEMRRSL
1460 1470 1480 1490 1500
KELNLGLKGE LTITTDVEDL STALFYDTVP DTWVARAYPS MMGLAAWYAD
1510 1520 1530 1540 1550
LLLRIRRLVC PCRNSRPGRQ TLPCPPPCGW PASSTPSRSS RPSCSPWPGR
1560
TSGPWTRCVC LSR
Length:1,563
Mass (Da):176,377
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD324E2A751FD7B9C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UFH2DYH17_HUMAN
Dynein heavy chain 17, axonemal
DNAH17 DNAHL1, DNEL2
4,462Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC016182 Genomic DNA No translation available.
AC061992 Genomic DNA No translation available.
KF510431 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000591369; ENSP00000466150; ENSG00000187775

UCSC genome browser

More...
UCSCi
uc060kuw.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016182 Genomic DNA No translation available.
AC061992 Genomic DNA No translation available.
KF510431 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

PeptideAtlasiK7ELN3
PRIDEiK7ELN3

Genome annotation databases

EnsembliENST00000591369; ENSP00000466150; ENSG00000187775
UCSCiuc060kuw.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000187775.16
HGNCiHGNC:2946, DNAH17
OpenTargetsiENSG00000187775

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154076
HOGENOMiCLU_000038_1_1_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNAH17, human

Gene expression databases

BgeeiENSG00000187775, Expressed in C1 segment of cervical spinal cord and 140 other tissues
ExpressionAtlasiK7ELN3, baseline and differential

Family and domain databases

Gene3Di1.10.8.720, 1 hit
InterProiView protein in InterPro
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041228, Dynein_C
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR027417, P-loop_NTPase
PANTHERiPTHR10676, PTHR10676, 1 hit
PfamiView protein in Pfam
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7ELN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7ELN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: August 12, 2020
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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