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Protein
Submitted name:

Intercellular adhesion molecule 1

Gene

ICAM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Intercellular adhesion molecule 1Imported
Gene namesi
Name:ICAM1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000090339.8
HGNCiHGNC:5344 ICAM1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000090339

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500390317028 – 180Sequence analysisAdd BLAST153

Proteomic databases

MaxQBiK7EKL8
PeptideAtlasiK7EKL8
PRIDEiK7EKL8

Expressioni

Gene expression databases

BgeeiENSG00000090339 Expressed in 205 organ(s), highest expression level in lung
ExpressionAtlasiK7EKL8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EKL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 115ICAM_NInterPro annotationAdd BLAST91

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000063246

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01472 ICAMVCAM1
SUPFAMiSSF48726 SSF48726, 2 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

K7EKL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST
60 70 80 90 100
SCDQPKLLGI ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ
110 120 130 140 150
STAKTFLTVY WTPERVEGGA PRANLTVVLL RGEKELKREP AVGEPAEVTT
160 170 180
TVLVRRDHHG ANFSCRTELD LRPQGLELFE
Length:180
Mass (Da):19,443
Last modified:January 9, 2013 - v1
Checksum:i71454EDE08E535BF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P05362ICAM1_HUMAN
Intercellular adhesion molecule 1
ICAM1
532Annotation score:
E7ESS4E7ESS4_HUMAN
Intercellular adhesion molecule 1
ICAM1
310Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei180Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011511 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000588645; ENSP00000465680; ENSG00000090339
UCSCiuc060tga.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011511 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7EKL8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiK7EKL8
PeptideAtlasiK7EKL8
PRIDEiK7EKL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588645; ENSP00000465680; ENSG00000090339
UCSCiuc060tga.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000090339.8
HGNCiHGNC:5344 ICAM1
OpenTargetsiENSG00000090339
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063246

Miscellaneous databases

ChiTaRSiICAM1 human

Gene expression databases

BgeeiENSG00000090339 Expressed in 205 organ(s), highest expression level in lung
ExpressionAtlasiK7EKL8 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01472 ICAMVCAM1
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiK7EKL8_HUMAN
AccessioniPrimary (citable) accession number: K7EKL8
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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