Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 52 (16 Oct 2019)
Sequence version 1 (09 Jan 2013)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Periplakin

Gene

PPL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PeriplakinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9273 PPL

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000118898

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
K7EKI8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
K7EKI8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
K7EKI8

PeptideAtlas

More...
PeptideAtlasi
K7EKI8

PRoteomics IDEntifications database

More...
PRIDEi
K7EKI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118898 Expressed in 206 organ(s), highest expression level in mouth mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
K7EKI8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
K7EKI8, 10 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini397 – 453SH3InterPro annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili24 – 51Sequence analysisAdd BLAST28
Coiled coili254 – 281Sequence analysisAdd BLAST28
Coiled coili355 – 382Sequence analysisAdd BLAST28
Coiled coili588 – 608Sequence analysisAdd BLAST21
Coiled coili695 – 715Sequence analysisAdd BLAST21
Coiled coili758 – 778Sequence analysisAdd BLAST21
Coiled coili789 – 816Sequence analysisAdd BLAST28
Coiled coili890 – 924Sequence analysisAdd BLAST35
Coiled coili948 – 989Sequence analysisAdd BLAST42
Coiled coili1001 – 1049Sequence analysisAdd BLAST49
Coiled coili1068 – 1109Sequence analysisAdd BLAST42
Coiled coili1128 – 1162Sequence analysisAdd BLAST35
Coiled coili1186 – 1220Sequence analysisAdd BLAST35
Coiled coili1246 – 1280Sequence analysisAdd BLAST35
Coiled coili1306 – 1354Sequence analysisAdd BLAST49
Coiled coili1373 – 1445Sequence analysisAdd BLAST73
Coiled coili1457 – 1491Sequence analysisAdd BLAST35
Coiled coili1507 – 1590Sequence analysisAdd BLAST84
Coiled coili1617 – 1637Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQBN Eukaryota
ENOG410YHVZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153578

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615 Desmoplakin_SH3
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17902 SH3_10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250 PLEC, 2 hits
SM00150 SPEC, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399 SSF75399, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

K7EKI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLFRKRNK GKYSPTVQTR SISNKELSEL IEQLQKNADQ VEKNIVDTEA
60 70 80 90 100
KMQSDLARLQ EGRQPEHRDV TLQKVLDSEK LLYVLEADAA IAKHMKHPQG
110 120 130 140 150
DMIAEDIRQL KERVTNLRGK HKQIYRLAVK EVDPQVNWAA LVEEKLDKLN
160 170 180 190 200
NQSFGTDLPL VDHQVEEHNI FHNEVKAIGP HLAKDGDKNS ELRAKYQKLL
210 220 230 240 250
AASQARQQHL SSLQDYMQRC TNELYWLDQQ AKGRMQYDWS DRNLDYPSRR
260 270 280 290 300
RQYENFINRN LEAKEERINK LHSEGDQLLA AEHPGRNSIE AHMEAVHADW
310 320 330 340 350
KEYLNLLICE ESHLKYMEDY HQFHEDVKDA QELLRKVDSD LNQKYGPDFK
360 370 380 390 400
DRYQIELLLR ELDDQEKVLD KYEDVVQGLQ KRGQQVVPLK YRRETPLKPI
410 420 430 440 450
PVEALCDFEG EQGLISRGYS YTLQKNNGES WELMDSAGNK LIAPAVCFVI
460 470 480 490 500
PPTDPEALAL ADSLGSQYRS VRQKAAGSKR TLQQRYEVLK TENPGDASDL
510 520 530 540 550
QGRQLLAGLD KVASDLDRQE KAITGILRPP LEQGRAVQDS AERAKDLKNI
560 570 580 590 600
TNELLRIEPE KTRSTAEGEA FIQALPGSGT TPLLRTRVED TNRKYEHLLQ
610 620 630 640 650
LLDLAQEKVD VANRLEKSLQ QSWELLATHE NHLNQDDTVP ESSRVLDSKG
660 670 680 690 700
QELAAMACEL QAQKSLLGEV EQNLQAAKQC SSTLASRFQE HCPDLERQEA
710 720 730 740 750
EVHKLGQRFN NLRQQVERRA QSLQSAKAAY EHFHRGHDHV LQFLVSIPSY
760 770 780 790 800
EPQETDSLSQ METKLKNQKN LLDEIASREQ EVQKICANSQ QYQQAVKDYE
810 820 830 840 850
LEAEKLRSLL DLENGRRSHV SKRARLQSPA TKVKEEEAAL AAKFTEVYAI
860 870 880 890 900
NRQRLQNLEF ALNLLRQQPE VEVTHETLQR NRPDSGVEEA WKIRKELDEE
910 920 930 940 950
TERRRQLENE VKSTQEEIWT LRNQGPQESV VRKEVLKKVP DPVLEESFQQ
960 970 980 990 1000
LQRTLAEEQH KNQLLQEELE ALQLQLRALE QETRDGGQEY VVKEVLRIEP
1010 1020 1030 1040 1050
DRAQADEVLQ LREELEALRR QKGAREAEVL LLQQRVAALA EEKSRAQEKV
1060 1070 1080 1090 1100
TEKEVVKLQN DPQLEAEYQQ LQEDHQRQDQ LREKQEEELS FLQDKLKRLE
1110 1120 1130 1140 1150
KERAMAEGKI TVKEVLKVEK DAATEREVSD LTRQYEDEAA KARASQREKT
1160 1170 1180 1190 1200
ELLRKIWALE EENAKVVVQE KVREIVRPDP KAESEVANLR LELVEQERKY
1210 1220 1230 1240 1250
RGAEEQLRSY QSELEALRRR GPQVEVKEVT KEVIKYKTDP EMEKELQRLR
1260 1270 1280 1290 1300
EEIVDKTRLI ERCDLEIYQL KKEIQALKDT KPQVQTKEVV QEILQFQEDP
1310 1320 1330 1340 1350
QTKEEVASLR AKLSEEQKKQ VDLERERASQ EEQIARKEEE LSRVKERVVQ
1360 1370 1380 1390 1400
QEVVRYEEEP GLRAEASAFA ESIDVELRQI DKLRAELRRL QRRRTELERQ
1410 1420 1430 1440 1450
LEELERERQA RREAEREVQR LQQRLAALEQ EEAEAREKVT HTQKVVLQQD
1460 1470 1480 1490 1500
PQQAREHALL RLQLEEEQHR RQLLEGELET LRRKLAALEK AEVKEKVVLS
1510 1520 1530 1540 1550
ESVQVEKGDT EQEIQRLKSS LEEESRSKRE LDVEVSRLEA RLSELEFHNS
1560 1570 1580 1590 1600
KSSKELDFLR EENHKLQLER QNLQLETRRL QSEINMAATE TRDLRNMTVA
1610 1620 1630 1640 1650
DSGTNHDSRL WSLERELDDL KRLSKDKDLE IDELQKRLGS VAVKREQREN
1660 1670 1680 1690 1700
HLRRSIVVIH PDTGRELSPE EAHRAGLIDW NMFVKLRSQE CDWEEISVKG
1710 1720 1730 1740 1750
PNGESSVIHD RKSGKKFSIE EALQSGRLTP AQYDRYVNKD MSIQELAVLV

SGQK
Length:1,754
Mass (Da):204,490
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1017E02B667D7D17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O60437PEPL_HUMAN
Periplakin
PPL KIAA0568
1,756Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ71K7EQ71_HUMAN
Periplakin
PPL
1,115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC027687 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000590782; ENSP00000465640; ENSG00000118898

UCSC genome browser

More...
UCSCi
uc059qkr.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027687 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiK7EKI8, 10 interactors

Proteomic databases

EPDiK7EKI8
jPOSTiK7EKI8
MaxQBiK7EKI8
PeptideAtlasiK7EKI8
PRIDEiK7EKI8

Genome annotation databases

EnsembliENST00000590782; ENSP00000465640; ENSG00000118898
UCSCiuc059qkr.1 human

Organism-specific databases

HGNCiHGNC:9273 PPL
OpenTargetsiENSG00000118898

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQBN Eukaryota
ENOG410YHVZ LUCA
GeneTreeiENSGT00940000153578

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPL human

Gene expression databases

BgeeiENSG00000118898 Expressed in 206 organ(s), highest expression level in mouth mucosa
ExpressionAtlasiK7EKI8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR041615 Desmoplakin_SH3
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PfamiView protein in Pfam
PF17902 SH3_10, 1 hit
SMARTiView protein in SMART
SM00250 PLEC, 2 hits
SM00150 SPEC, 5 hits
SUPFAMiSSF75399 SSF75399, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7EKI8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7EKI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: October 16, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again