Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 51 (22 Apr 2020)
Sequence version 1 (09 Jan 2013)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Dynein heavy chain 17, axonemal

Gene

DNAH17

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dynein heavy chain 17, axonemalImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187775.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2946 DNAH17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000187775

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
K7EK91

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
K7EK91

PeptideAtlas

More...
PeptideAtlasi
K7EK91

PRoteomics IDEntifications database

More...
PRIDEi
K7EK91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187775 Expressed in C1 segment of cervical spinal cord and 121 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
K7EK91 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
K7EK91, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini190 – 767DHC_N1InterPro annotationAdd BLAST578
Domaini1266 – 1671DHC_N2InterPro annotationAdd BLAST406
Domaini1804 – 2130AAA_6InterPro annotationAdd BLAST327
Domaini2288 – 2406Dynein_AAA_lidInterPro annotationAdd BLAST119
Domaini2623 – 2721AAA_lid_1InterPro annotationAdd BLAST99
Domaini2766 – 3025AAA_8InterPro annotationAdd BLAST260
Domaini3038 – 3381MTInterPro annotationAdd BLAST344
Domaini3408 – 3625AAA_9InterPro annotationAdd BLAST218
Domaini3866 – 3993Dynein_heavyInterPro annotationAdd BLAST128
Domaini3995 – 4154AAA_lid_11InterPro annotationAdd BLAST160
Domaini4162 – 4455Dynein_CInterPro annotationAdd BLAST294

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili768 – 802Sequence analysisAdd BLAST35
Coiled coili808 – 828Sequence analysisAdd BLAST21
Coiled coili1029 – 1049Sequence analysisAdd BLAST21
Coiled coili1380 – 1400Sequence analysisAdd BLAST21
Coiled coili1550 – 1570Sequence analysisAdd BLAST21
Coiled coili3030 – 3081Sequence analysisAdd BLAST52
Coiled coili3253 – 3301Sequence analysisAdd BLAST49
Coiled coili3569 – 3589Sequence analysisAdd BLAST21
Coiled coili3625 – 3645Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_4_0_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676 PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

K7EK91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMAPDVRLE YLEEVASIVL KFKPDKWSKL IGAEENVALF TEFFEKPDVQ
60 70 80 90 100
VLVLTLNAAG MIIPCLGFPQ SLKSKGVYFI KTKSENINKD NYRARLLYGD
110 120 130 140 150
ISPTPVDQLI AVVEEVLSSL LNQSENMAGW PQVVSEDIVK QVHRLKNEMF
160 170 180 190 200
VMSGKIKGKT LLPIPEHLGS LDGTLESMER IPSSLDNLLL HAIETTIIDW
210 220 230 240 250
SHQIRDVLSK DSAQALLDGL HPLPQVEFEF WDTRLLNLKC IHEQLNRPKV
260 270 280 290 300
NKIVEILEKA KSCYWPALQN VYTNVTEGLK EANDIVLYLK PLRILLEEME
310 320 330 340 350
QADFTMLPTF IAKVLDTICF IWATSEYYNT PARIIVILQE FCNQIIEMTR
360 370 380 390 400
TFLSPEEVLK GLQGEIEEVL SGISLAVNVL KELYQTYDFC CVNMKLFFKD
410 420 430 440 450
KEPVPWEFPS SLAFSRINSF FQRIQTIEEL YKTAIEFLKL EKIELGGVRG
460 470 480 490 500
NLLGSLVTRI YDEVFELVKV FADCKYDPLD PGDSNFDRDY ADFEIKIQDL
510 520 530 540 550
DRRLATIFCQ GFDDCSCIKS SAKLLYMCGG LMERPLILAE VAPRYSVMLE
560 570 580 590 600
LFDAELDNAK ILYDAQMAAS EEGNIPLIHK NMPPVAGQLK WSLELQERLE
610 620 630 640 650
VSMKHLKHVE HPVMSGAEAK LTYQKYDEMM ELLRCHREKI YQQWVAGVDQ
660 670 680 690 700
DCHFNLGQPL ILRDAASNLI HVNFSKALVA VLREVKYLNF QQQKEIPDSA
710 720 730 740 750
ESLFSENETF RKFVGNLELI VGWYNEIKTI VKAVEFLLIK SELEAIDVKL
760 770 780 790 800
LSAETTLFWN GEGVFQYIQE VREILHNLQN RMQKAKQNIE GISQAMKDWS
810 820 830 840 850
ANPLFERKDN KKEALLDLDG RIANLNKRYA AVRDAGVKIQ AMVAENAELF
860 870 880 890 900
RADTLSLPWK DYVIYIDDMV LDEFDQFIRK SLSFLMDNME SIAPLFEIRM
910 920 930 940 950
ELDEDGLTFN PTLEVGSDRG FLALIEGLVN DIYNVARLIP RLAKDRMNYK
960 970 980 990 1000
MDLEDNTDLI EMREEVSSLV INAMKEAEEY QDSFERYSYL WTDNLQEFMK
1010 1020 1030 1040 1050
NFLIYGCAVT AEDLDTWTDD TIPKTPPTLA QFQEQIDSYE KLYEEVSKCE
1060 1070 1080 1090 1100
NTKVFHGWLQ CDCRPFKQAL LSTIRRWGFM FKRHLSNHVT NSLADLEAFM
1110 1120 1130 1140 1150
KVARMGLTKP LKEGDYDGLV EVMGHLMKVK ERQAATDNMF EPLKQTIELL
1160 1170 1180 1190 1200
KTYGEEMPEE IHLKLQELPE HWANTKKLAI QVKLTVAPLQ ANEVSILRRK
1210 1220 1230 1240 1250
CQQFELKQHE FRERFRREAP FSFSDPNPYK SLNKQQKSIS AMEGIMEALS
1260 1270 1280 1290 1300
KSGGLFEVPV PDYKQLKACH REVRLLKELW DMVVVVNTSI EDWKTTKWKD
1310 1320 1330 1340 1350
INVEQMDIDC KKFAKDMRSL DKEMKTWDAF VGLDNTVKNV ITSLRAVSEL
1360 1370 1380 1390 1400
QNPAIRERHW QQLMQATQVK FKMSEETTLA DLLQLNLHSY EDEVRNIVDK
1410 1420 1430 1440 1450
AVKESGMEKV LKALDSTWSM MEFQHEPHPR TGTMMLKSSE VLVETLEDNQ
1460 1470 1480 1490 1500
VQLQNLMMSK YLAHFLKEVT SWQQKLSTAD SVISIWFEVQ RTWSHLESIF
1510 1520 1530 1540 1550
IGSEDIRTQL PGDSQRFDDI NQEFKALMED AVKTPNVVEA TSKPGLYNKL
1560 1570 1580 1590 1600
EALKKSLAIC EKALAEYLET KRLAFPRFYF VSSADLLDIL SNGNDPVEVS
1610 1620 1630 1640 1650
RHLSKLFDSL CKLKFRLDAS DKPLKVGLGM YSKEDEYMVF DQECDLSGQV
1660 1670 1680 1690 1700
EVWLNRVLDR MCSTLRHEIP EAVVTYEEKP REQWILDYPA QVALTCTQIW
1710 1720 1730 1740 1750
WTTEVGLAFA RLEEGYENAI RDYNKKQISQ LNVLITLLMG NLNAGDRMKI
1760 1770 1780 1790 1800
MTICTIDVHA RDVVAKMIVV ESSQAFTWQA QLRHRWDEEK RHCFANICDA
1810 1820 1830 1840 1850
QIQYSYEYLG NTPRLVITPL TDRCYITLTQ SLHLIMGGAP AGPAGTGKTE
1860 1870 1880 1890 1900
TTKDLGRALG TMVYVFNCSE QMDYKSCGNI YKGLAQTGAW GCFDEFNRIS
1910 1920 1930 1940 1950
VEVLSVIAVQ VKCVQDAIRA KKKAFNFLGE IIGLIPTVGI FITMNPGYAG
1960 1970 1980 1990 2000
RAELPENLKA LFRPCAMVVP DFELICEIML MAEGFLEARL LARKFITLYT
2010 2020 2030 2040 2050
LCKELLSKQD HYDWGLRAIK SVLVVAGSLK RGDPSRAEDQ VLMRALRDFN
2060 2070 2080 2090 2100
IPKIVTDDLP VFMGLIGDLF PALDVPRKRD LNFEKIIKQS IVELKLQAED
2110 2120 2130 2140 2150
SFVLKVVQLE ELLQVRHSVF IVGNAGSGKS QVLKSLNKTY QNLKRKPVAV
2160 2170 2180 2190 2200
DLDPKAVTCD ELFGIINPVT REWKDGLFST IMRDLANITH DGPKWIILDG
2210 2220 2230 2240 2250
DIDPMWIESL NTVMDDNKVL TLASNERIPL NRTMRLVFEI SHLRTATPAT
2260 2270 2280 2290 2300
VSRAGILYIN PADLGWNPVV SSWIERRKVQ SEKANLMILF DKYLPTCLDK
2310 2320 2330 2340 2350
LRFGFKKITP VPEITVIQTI LYLLECLLTE KTVPPDSPRE LYELYFVFTC
2360 2370 2380 2390 2400
FWAFGGAMFQ DQLVDYRVEF SKWWINEFKT IKFPSQGTIF DYYIDPDTKK
2410 2420 2430 2440 2450
FLPWTDKVPS FELDPDVPLQ ASLVHTTETI RIRYFMDLLM EKSWPVMLVG
2460 2470 2480 2490 2500
NAGTGKSVLM GDKLESLNTD NYLVQAVPFN FYTTSAMLQG VLEKPLEKKS
2510 2520 2530 2540 2550
GRNYGPPGTK KLVYFIDDMN MPEVDKYGTV APHTLIRQHM DHRHWYDRHK
2560 2570 2580 2590 2600
LTLKDIHNCQ YVACMNPTSG SFTIDSRLQR HFCVFAVSFP GQEALTTIYN
2610 2620 2630 2640 2650
TILTQHLAFR SVSMAIQRIS SQLVAAALAL HQKITATFLP TAIKFHYVFN
2660 2670 2680 2690 2700
LRDLSNIFQG LLFSTAEVLK TPLDLVRLWL HETERVYGDK MVDEKDQETL
2710 2720 2730 2740 2750
HRVTMASTKK FFDDLGDELL FAKPNIFCHF AQGIGDPKYV PVTDMAPLNK
2760 2770 2780 2790 2800
LLVDVLDSYN EVNAVMNLVL FEDAVAHICR INRILESPRG NALLVGVGGS
2810 2820 2830 2840 2850
GKQSLSRLAA YISGLDVFQI TLKKGYGIPD LKIDLAAQYI KAAVKNVPSV
2860 2870 2880 2890 2900
FLMTDSQVAE EQFLVLINDL LASGEIPGLF MEDEVENIIS SMRPQVKSLG
2910 2920 2930 2940 2950
MNDTRETCWK FFIEKVRRQL KVILCFSPVG SVLRVRARKF PAVVNCTAID
2960 2970 2980 2990 3000
WFHEWPEDAL VSVSARFLEE TEGIPWEVKA SISFFMSYVH TTVNEMSRVY
3010 3020 3030 3040 3050
LATERRYNYT TPKTFLEQIK LYQNLLAKKR TELVAKIERL ENGLMKLQST
3060 3070 3080 3090 3100
ASQVDDLKAK LAIQEAELKQ KNESADQLIQ VVGIEAEKVS KEKAIADQEE
3110 3120 3130 3140 3150
VKVEVINKNV TEKQKACETD LAKAEPALLA AQEALDTLNK NNLTELKSFG
3160 3170 3180 3190 3200
SPPDAVVNVT AAVMILTAPG GKIPKDKSWK AAKIMMGKVD TFLDSLKKFD
3210 3220 3230 3240 3250
KEHIPEACLK AFKPYQGNPT FDPEFIRSKS TAAAGLCSWC INIVRFYEVY
3260 3270 3280 3290 3300
CDVAPKRQAL EEANAELAEA QEKLSRIKNK IAELNANLSN LTSAFEKATA
3310 3320 3330 3340 3350
EKIKCQQEAD ATNRVILLAN RLVGGLASEN IRWAESVENF RSQGVTLCGD
3360 3370 3380 3390 3400
VLLISAFVSY VGYFTKKYRN ELMEKFWIPY IHNLKVPIPI TNGLDPLSLL
3410 3420 3430 3440 3450
TDDADVATWN NQGLPSDRMS TENATILGNT ERWPLIVDAQ LQGIKWIKNK
3460 3470 3480 3490 3500
YRSELKAIRL GQKSYLDVIE QAISEGDTLL IENIGETVDP VLDPLLGRNT
3510 3520 3530 3540 3550
IKKGKYIKIG DKEVEYHPKF RLILHTKYFN PHYKPEMQAQ CTLINFLVTR
3560 3570 3580 3590 3600
DGLEDQLLAA VVAKERPDLE QLKANLTKSQ NEFKIVLKEL EDSLLARLSA
3610 3620 3630 3640 3650
ASGNFLGDTA LVENLETTKH TASEIEEKVV EAKITEVKIN EARENYRPAA
3660 3670 3680 3690 3700
ERASLLYFIL NDLNKINPVY QFSLKAFNVV FEKAIQRTTP ANEVKQRVIN
3710 3720 3730 3740 3750
LTDEITYSVY MYTARGLFER DKLIFLAQVT FQVLSMKKEL NPVELDFLLR
3760 3770 3780 3790 3800
FPFKAGVVSP VDFLQHQGWG GIKALSEMDE FKNLDSDIEG SAKRWKKLVE
3810 3820 3830 3840 3850
SEAPEKEIFP KEWKNKTALQ KLCMVRCLRP DRMTYAIKNF VEEKMGSKFV
3860 3870 3880 3890 3900
EGRSVEFSKS YEESSPSTSI FFILSPGVDP LKDVEALGKK LGFTIDNGKL
3910 3920 3930 3940 3950
HNVSLGQGQE VVAENALDVA AEKGHWVILQ NIHLVARWLG TLDKKLEHYS
3960 3970 3980 3990 4000
TGSHEDYRVF ISAEPAPSPE THIIPQGILE NAIKITNEPP TGMHANLHKA
4010 4020 4030 4040 4050
LDLFTQDTLE MCTKEMEFKC MLFALCYFHA VVAERRKFGA QGWNRSYPFN
4060 4070 4080 4090 4100
NGDLTISINV LYNYLEANPK VPWDDLRYLF GEIMYGGHIT DDWDRRLCRT
4110 4120 4130 4140 4150
YLAEYIRTEM LEGDVLLAPG FQIPPNLDYK GYHEYIDENL PPESPYLYGL
4160 4170 4180 4190 4200
HPNAEIGFLT VTSEKLFRTV LEMQPKETDS GAGTGVSREE KVKAVLDDIL
4210 4220 4230 4240 4250
EKIPETFNMA EIMAKAAEKT PYVVVAFQEC ERMNILTNEM RRSLKELNLG
4260 4270 4280 4290 4300
LKGELTITTD VEDLSTALFY DTVPDTWVAR AYPSMMGLAA WYADLLLRIR
4310 4320 4330 4340 4350
ELEAWTTDFA LPTTVWLAGF FNPQSFLTAI MQSMARKNEW PLDKMCLSVE
4360 4370 4380 4390 4400
VTKKNREDMT APPREGSYVY GLFMEGARWD TQTGVIAEAR LKELTPAMPV
4410 4420 4430 4440 4450
IFIKAIPVDR METKNIYECP VYKTRIRGPT YVWTFNLKTK EKAAKWILAA

VALLLQV
Length:4,457
Mass (Da):508,786
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0119A0C9DA548A6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UFH2DYH17_HUMAN
Dynein heavy chain 17, axonemal
DNAH17 DNAHL1, DNEL2
4,462Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELN3K7ELN3_HUMAN
Dynein heavy chain 17, axonemal
DNAH17
1,563Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC016182 Genomic DNA No translation available.
AC061992 Genomic DNA No translation available.
KF510431 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000585328; ENSP00000465516; ENSG00000187775

UCSC genome browser

More...
UCSCi
uc060kux.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016182 Genomic DNA No translation available.
AC061992 Genomic DNA No translation available.
KF510431 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiK7EK91, 1 interactor

Proteomic databases

EPDiK7EK91
jPOSTiK7EK91
PeptideAtlasiK7EK91
PRIDEiK7EK91

Genome annotation databases

EnsembliENST00000585328; ENSP00000465516; ENSG00000187775
UCSCiuc060kux.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000187775.16
HGNCiHGNC:2946 DNAH17
OpenTargetsiENSG00000187775

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000154076
HOGENOMiCLU_000038_4_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNAH17 human

Gene expression databases

BgeeiENSG00000187775 Expressed in C1 segment of cervical spinal cord and 121 other tissues
ExpressionAtlasiK7EK91 baseline and differential

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7EK91_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7EK91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: April 22, 2020
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again