UniProtKB - K7EJW6 (K7EJW6_HUMAN)
Protein
Submitted name:
ATP-binding cassette sub-family A member 5
Gene
ABCA5
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 299 – 306 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
GO - Biological processi
- cholesterol transport Source: InterPro
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette sub-family A member 5Imported |
Gene namesi | Name:ABCA5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:35, ABCA5 |
VEuPathDBi | HostDB:ENSG00000154265.15 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 30 – 56 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 68 – 90 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 102 – 124 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 131 – 153 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 173 – 194 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000154265, Expressed in intestine and 238 other tissues |
ExpressionAtlasi | K7EJW6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 256 – 499 | ABC transporterInterPro annotationAdd BLAST | 244 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 215 – 234 | DisorderedSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000158172 |
HOGENOMi | CLU_000604_1_2_1 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR026082, ABCA IPR030367, ABCA5 IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit PTHR19229:SF100, PTHR19229:SF100, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
K7EJW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPYFAMENA ENHKIKAYTQ LKLSGLLPSA YWIGQAVVDI PLFFIILILM
60 70 80 90 100
LGSLLAFHYG LYFYTVKFLA VVFCLIGYVP SVILFTYIAS FTFKKILNTK
110 120 130 140 150
EFWSFIYSVA ALACIAITEI TFFMGYTIAT ILHYAFCIII PIYPLLGCLI
160 170 180 190 200
SFIKISWKNV RKNVDTYNPW DRLSVAVISP YLQCVLWIFL LQYYEKKYGG
210 220 230 240 250
RSIRKDPFFR NLSTKSKNRK LPEPPDNEDE DEDVKAERLK VKELMGCQCC
260 270 280 290 300
EEKPSIMVSN LHKEYDDKKD FLLSRKVKKV ATKYISFCVK KGEILGLLGP
310 320 330 340 350
NGAGKSTIIN ILVGDIEPTS GQVFLGDYSS ETSEDDDSLK CMGYCPQINP
360 370 380 390 400
LWPDTTLQEH FEIYGAVKGM SASDMKEVIS RITHALDLKE HLQKTVKKLP
410 420 430 440 450
AGIKRKLCFA LSMLGNPQIT LLDEPSTGMD PKAKQHMWRA IRTAFKNRKR
460 470 480 490 500
AAILTTHYME EAEAVCDRVA IMVSGQLRCI GTVQHLKSKF GKGYFLEIKL
510 520 530 540 550
KDWIENLEVD RLQREIQYIF PNASRQESFS SILAYKIPKE DVQSLSQSFF
560 570
KLEEAKHAFA IEEYSFSQAT LEQ
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8WWZ7 | ABCA5_HUMAN | Cholesterol transporter ABCA5 | ABCA5 KIAA1888 | 1,642 | Annotation score: | ||
Q6N017 | Q6N017_HUMAN | ATP-binding cassette sub-family A m... | ABCA5 DKFZp686K07118 | 431 | Annotation score: | ||
K7EPM3 | K7EPM3_HUMAN | ATP-binding cassette sub-family A m... | ABCA5 | 917 | Annotation score: | ||
K7EMV2 | K7EMV2_HUMAN | ATP-binding cassette sub-family A m... | ABCA5 | 127 | Annotation score: | ||
K7ENF9 | K7ENF9_HUMAN | ATP-binding cassette sub-family A m... | ABCA5 | 192 | Annotation score: | ||
A0A075B778 | A0A075B778_HUMAN | ATP-binding cassette sub-family A m... | ABCA5 | 250 | Annotation score: | ||
K7EKS9 | K7EKS9_HUMAN | ATP-binding cassette sub-family A m... | ABCA5 | 63 | Annotation score: | ||
K7EQ50 | K7EQ50_HUMAN | ATP-binding cassette sub-family A m... | ABCA5 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 573 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005495 Genomic DNA No translation available. AC115085 Genomic DNA No translation available. KF456324 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000586811; ENSP00000465351; ENSG00000154265 |
UCSCi | uc060jhm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005495 Genomic DNA No translation available. AC115085 Genomic DNA No translation available. KF456324 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | K7EJW6 |
PRIDEi | K7EJW6 |
Protocols and materials databases
Antibodypediai | 19335, 176 antibodies |
Genome annotation databases
Ensembli | ENST00000586811; ENSP00000465351; ENSG00000154265 |
UCSCi | uc060jhm.1, human |
Organism-specific databases
HGNCi | HGNC:35, ABCA5 |
OpenTargetsi | ENSG00000154265 |
VEuPathDBi | HostDB:ENSG00000154265.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158172 |
HOGENOMi | CLU_000604_1_2_1 |
Miscellaneous databases
ChiTaRSi | ABCA5, human |
Gene expression databases
Bgeei | ENSG00000154265, Expressed in intestine and 238 other tissues |
ExpressionAtlasi | K7EJW6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR026082, ABCA IPR030367, ABCA5 IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit PTHR19229:SF100, PTHR19229:SF100, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K7EJW6_HUMAN | |
Accessioni | K7EJW6Primary (citable) accession number: K7EJW6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | October 5, 2016 | |
Last modified: | April 7, 2021 | |
This is version 60 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |