UniProtKB - K7EJU1 (K7EJU1_HUMAN)
Protein
Glial fibrillary acidic protein
Gene
GFAP
Organism
Homo sapiens (Human)
Status
Functioni
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.ARBA annotation
Names & Taxonomyi
Protein namesi | Recommended name: Glial fibrillary acidic proteinARBA annotation |
Gene namesi | Name:GFAPImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4235, GFAP |
VEuPathDBi | HostDB:ENSG00000131095.11 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Keywords - Cellular componenti
Intermediate filamentUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000131095, Expressed in dorsal motor nucleus of vagus nerve and 153 other tissues |
ExpressionAtlasi | K7EJU1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 248 | IF rodInterPro annotationAdd BLAST | 180 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 73 – 107 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 113 – 210 | Sequence analysisAdd BLAST | 98 |
Sequence similaritiesi
Belongs to the intermediate filament family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159539 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR027701, GFAP IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR006821, Intermed_filament_DNA-bd |
PANTHERi | PTHR45652:SF9, PTHR45652:SF9, 2 hits |
Pfami | View protein in Pfam PF00038, Filament, 2 hits PF04732, Filament_head, 1 hit |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All
K7EJU1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERRRITSAA RRSYVSSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV
60 70 80 90 100
DFSLAGALNA GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE
110 120 130 140 150
LNQLRAKEPT KLADVYQAEL RELRLRLDQL TANSARLEVE RDNLAQDLAT
160 170 180 190 200
VRQKLQDETN LRLEAENNLA AYRQEADEAT LARLDLERKI ESLEEEIRFL
210 220 230 240
RKIHEEEYQD LLNVKLALDI EIATYRKLLE GEENRITIPV QTFSNLQI
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP14136 | GFAP_HUMAN | Glial fibrillary acidic protein | GFAP | 432 | Annotation score: | ||
A0A1W2PR46 | A0A1W2PR46_HUMAN | Glial fibrillary acidic protein | GFAP | 505 | Annotation score: | ||
A0A1W2PRT3 | A0A1W2PRT3_HUMAN | Glial fibrillary acidic protein | GFAP | 326 | Annotation score: | ||
A0A1X7SBR3 | A0A1X7SBR3_HUMAN | Glial fibrillary acidic protein | GFAP | 472 | Annotation score: | ||
A0A1X7SCE1 | A0A1X7SCE1_HUMAN | Glial fibrillary acidic protein | GFAP | 334 | Annotation score: | ||
K7EPI4 | K7EPI4_HUMAN | Glial fibrillary acidic protein | GFAP | 124 | Annotation score: | ||
A0A1W2PPA3 | A0A1W2PPA3_HUMAN | Glial fibrillary acidic protein | GFAP | 69 | Annotation score: | ||
K7EKH9 | K7EKH9_HUMAN | Glial fibrillary acidic protein | GFAP | 261 | Annotation score: | ||
A0A1W2PS58 | A0A1W2PS58_HUMAN | Glial fibrillary acidic protein | GFAP | 67 | Annotation score: | ||
B4DIR1 | B4DIR1_HUMAN | Glial fibrillary acidic protein | GFAP | 179 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 248 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015936 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000592320; ENSP00000465320; ENSG00000131095 |
UCSCi | uc060gdq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015936 Genomic DNA No translation available. |
3D structure databases
SMRi | K7EJU1 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | K7EJU1 |
PRIDEi | K7EJU1 |
Protocols and materials databases
Antibodypediai | 3505, 2939 antibodies |
Genome annotation databases
Ensembli | ENST00000592320; ENSP00000465320; ENSG00000131095 |
UCSCi | uc060gdq.1, human |
Organism-specific databases
HGNCi | HGNC:4235, GFAP |
OpenTargetsi | ENSG00000131095 |
VEuPathDBi | HostDB:ENSG00000131095.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159539 |
Miscellaneous databases
ChiTaRSi | GFAP, human |
Gene expression databases
Bgeei | ENSG00000131095, Expressed in dorsal motor nucleus of vagus nerve and 153 other tissues |
ExpressionAtlasi | K7EJU1, baseline and differential |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR027701, GFAP IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR006821, Intermed_filament_DNA-bd |
PANTHERi | PTHR45652:SF9, PTHR45652:SF9, 2 hits |
Pfami | View protein in Pfam PF00038, Filament, 2 hits PF04732, Filament_head, 1 hit |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K7EJU1_HUMAN | |
Accessioni | K7EJU1Primary (citable) accession number: K7EJU1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | January 9, 2013 | |
Last modified: | April 7, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |