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Protein
Submitted name:

Non-receptor tyrosine-protein kinase TYK2

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Non-receptor tyrosine-protein kinase TYK2Imported
Gene namesi
Name:TYK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105397.13
HGNCiHGNC:12440 TYK2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105397

PTM / Processingi

Proteomic databases

MaxQBiK7EJR6
PeptideAtlasiK7EJR6

Expressioni

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
ExpressionAtlasiK7EJR6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EJR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 142Protein kinaseInterPro annotationAdd BLAST103

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.iShow all

K7EJR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SFRTILRDLT RLQPHNLADV LTVNPDSPAS DPTVFHKRYL KKIRDLGEGH
60 70 80 90 100
FGKVSLYCYD PTNDGTGEMV AVKALKADCG PQHRSGWKQE IDILRTLYHE
110 120 130 140
HIIKYKGCCE DQGLSSHEEL LGDRGVLSPN LREPHTHSED SP
Length:142
Mass (Da):16,031
Last modified:January 9, 2013 - v1
Checksum:i33EEB46494003E4D
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P29597TYK2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
1,187Annotation score:
E9PPF2E9PPF2_HUMAN
Tyrosine-protein kinase
TYK2
921Annotation score:
E9PM19E9PM19_HUMAN
Tyrosine-protein kinase
TYK2
1,002Annotation score:
K7EM33K7EM33_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
135Annotation score:
E9PQL2E9PQL2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
118Annotation score:
H0YE24H0YE24_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
64Annotation score:
H0YCT7H0YCT7_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
82Annotation score:
H0YE41H0YE41_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
194Annotation score:
E9PQE9E9PQE9_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
134Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011557 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000530560; ENSP00000465291; ENSG00000105397
UCSCiuc060thm.1 human

Similar proteinsi

Entry informationi

Entry nameiK7EJR6_HUMAN
AccessioniPrimary (citable) accession number: K7EJR6
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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