UniProtKB - K7EIJ1 (K7EIJ1_HUMAN)
Protein
Submitted name:
Zinc phosphodiesterase ELAC protein 1
Gene
ELAC1
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- endoribonuclease activity, producing 5'-phosphomonoesters Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- tRNA 3'-trailer cleavage Source: InterPro
Keywordsi
Molecular function | EndonucleaseARBA annotation, Hydrolase, Nuclease |
Biological process | tRNA processingARBA annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc phosphodiesterase ELAC protein 1Imported |
Gene namesi | Name:ELAC1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14197, ELAC1 |
VEuPathDBi | HostDB:ENSG00000141642.8 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000141642, Expressed in amniotic fluid and 177 other tissues |
ExpressionAtlasi | K7EIJ1, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 75 | Lactamase_BInterPro annotationAdd BLAST | 56 |
Phylogenomic databases
GeneTreei | ENSGT00730000111224 |
HOGENOMi | CLU_031317_2_0_1 |
Family and domain databases
CDDi | cd07717, RNaseZ_ZiPD-like_MBL-fold, 1 hit |
Gene3Di | 3.60.15.10, 1 hit |
InterProi | View protein in InterPro IPR001279, Metallo-B-lactamas IPR036866, RibonucZ/Hydroxyglut_hydro IPR013471, RNase_Z/BN |
Pfami | View protein in Pfam PF00753, Lactamase_B, 1 hit |
SUPFAMi | SSF56281, SSF56281, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
K7EIJ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSMDVTFLGT GAAYPSPTRG ASAVVLRCEG ECWLFDCGEG TQTQLMKSQL
60 70 80 90 100
KAGRITKIFI THLHGDHFFG LPGLLCTISL QSGSMVSKQP IEIYGPVGLR
110 120 130 140 150
DFIWRTMELS HTELVFHYVV HELVPTADQC PAEELKEFAH VNRADSPPKE
160 170 180 190 200
EQGRTILLDS EENSYLLFDD EQFVVKAFRL FHRIPSFGFS VVEKKRPGKL
210 220
NAQKLKDLGK CFFVFCFFPP SHQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9H777 | RNZ1_HUMAN | Zinc phosphodiesterase ELAC protein... | ELAC1 D29 | 363 | Annotation score: | ||
K7EPH7 | K7EPH7_HUMAN | ElaC homolog 1 (E. coli), isoform C... | ELAC1 hCG_23690 | 88 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC087687 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000591429; ENSP00000464770; ENSG00000141642 |
UCSCi | uc010dpe.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC087687 Genomic DNA No translation available. |
3D structure databases
SMRi | K7EIJ1 |
ModBasei | Search... |
Proteomic databases
MaxQBi | K7EIJ1 |
PeptideAtlasi | K7EIJ1 |
PRIDEi | K7EIJ1 |
Protocols and materials databases
Antibodypediai | 22721, 233 antibodies |
Genome annotation databases
Ensembli | ENST00000591429; ENSP00000464770; ENSG00000141642 |
UCSCi | uc010dpe.4, human |
Organism-specific databases
HGNCi | HGNC:14197, ELAC1 |
OpenTargetsi | ENSG00000141642 |
VEuPathDBi | HostDB:ENSG00000141642.8 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00730000111224 |
HOGENOMi | CLU_031317_2_0_1 |
Miscellaneous databases
ChiTaRSi | ELAC1, human |
Gene expression databases
Bgeei | ENSG00000141642, Expressed in amniotic fluid and 177 other tissues |
ExpressionAtlasi | K7EIJ1, baseline and differential |
Family and domain databases
CDDi | cd07717, RNaseZ_ZiPD-like_MBL-fold, 1 hit |
Gene3Di | 3.60.15.10, 1 hit |
InterProi | View protein in InterPro IPR001279, Metallo-B-lactamas IPR036866, RibonucZ/Hydroxyglut_hydro IPR013471, RNase_Z/BN |
Pfami | View protein in Pfam PF00753, Lactamase_B, 1 hit |
SUPFAMi | SSF56281, SSF56281, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K7EIJ1_HUMAN | |
Accessioni | K7EIJ1Primary (citable) accession number: K7EIJ1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | January 9, 2013 | |
Last modified: | February 10, 2021 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |