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Protein

Homeobox protein

Gene

PITX2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi39 – 98HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox proteinUniRule annotation
Gene namesi
Name:PITX2Imported
ORF Names:CK820_G0024067Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:12956 PITX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliK7DFT6
SMRiK7DFT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 97HomeoboxInterPro annotationAdd BLAST61
Domaini233 – 246OARInterPro annotationAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi233 – 246OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family. Bicoid subfamily.UniRule annotation

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
GeneTreeiENSGT00930000150861
OMAiSACPYAP

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

K7DFT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METNCRKLVS ACVQLEKDKS QQGKNEDVGA EDPSKKKRQR RQRTHFTSQQ
60 70 80 90 100
LQELEATFQR NRYPDMSTRE EIAVWTNLTE ARVRVWFKNR RAKWRKRERN
110 120 130 140 150
QQAELCKNGF GPQFNGLMQP YDDMYPGYSY NNWAAKGLTS ASLSTKSFPF
160 170 180 190 200
FNSMNVNPLS SQSMFSPPNS ISSMSMSSSM VPSAVTGVPG SSLNSLNNLN
210 220 230 240 250
NLSSPSLNSA VPTPACPYAP PTPPYVYRDT CNSSLASLRL KAKQHSSFGY
260 270
ASVQNPASNL SACQYAVDRP V
Length:271
Mass (Da):30,336
Last modified:January 9, 2013 - v1
Checksum:i45D2ADA6DF03FF65
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2QQ16H2QQ16_PANTR
Homeobox protein
PITX2 CK820_G0024067
324Annotation score:
K7DRL4K7DRL4_PANTR
Homeobox protein
PITX2 CK820_G0024067
317Annotation score:
A0A2I3RUD9A0A2I3RUD9_PANTR
PITX2 isoform 8
PITX2 CK820_G0024067
174Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04021140 Genomic DNA No translation available.
GABE01004765 mRNA Translation: JAA39974.1
NBAG03000271 Genomic DNA Translation: PNI53646.1
NBAG03000271 Genomic DNA Translation: PNI53652.1
RefSeqiXP_009446418.1, XM_009448143.2

Genome annotation databases

EnsembliENSPTRT00000083052; ENSPTRP00000082192; ENSPTRG00000016371
GeneIDi461438

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04021140 Genomic DNA No translation available.
GABE01004765 mRNA Translation: JAA39974.1
NBAG03000271 Genomic DNA Translation: PNI53646.1
NBAG03000271 Genomic DNA Translation: PNI53652.1
RefSeqiXP_009446418.1, XM_009448143.2

3D structure databases

ProteinModelPortaliK7DFT6
SMRiK7DFT6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000083052; ENSPTRP00000082192; ENSPTRG00000016371
GeneIDi461438

Organism-specific databases

CTDi5308
VGNCiVGNC:12956 PITX2

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
GeneTreeiENSGT00930000150861
OMAiSACPYAP

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7DFT6_PANTR
AccessioniPrimary (citable) accession number: K7DFT6
Secondary accession number(s): A0A2J8M2A1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: November 7, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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