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Protein

Ribosomal protein S6 kinase

Gene

RPS6KA6

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105ATPUniRule annotation1
Active sitei198Proton acceptorUniRule annotation1
Binding sitei455ATPUniRule annotation1
Active sitei543Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 87ATPUniRule annotation9
Nucleotide bindingi432 – 440ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinaseUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:RPS6KA6Imported
ORF Names:CK820_G0038400Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:13433 RPS6KA6

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSPTRG00000022064

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000037953

Structurei

3D structure databases

SMRiK7D2H3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 330Protein kinaseInterPro annotationAdd BLAST258
Domaini331 – 400AGC-kinase C-terminalInterPro annotationAdd BLAST70
Domaini426 – 683Protein kinaseInterPro annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148962
KOiK04373
TreeFamiTF313438

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016239 Ribosomal_S6_kinase_II
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000606 Ribsml_S6_kin_2, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 2 hits
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 2 hits
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

Sequencei

Sequence statusi: Complete.

K7D2H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFAPQDEP WDREMEVFSG GGASSGEVNG LKMVDEPMEE GEADSCHDEG
60 70 80 90 100
VVKEIPITHH VKEGYEKADP AQFELLKVLG QGSFGKVFLV RKKTGPDAGQ
110 120 130 140 150
LYAMKVLKKA SLKVRDRVRT KMERDILVEV NHPFIVKLHY AFQTEGKLYL
160 170 180 190 200
ILDFLRGGDV FTRLSKEVLF TEEDVKFYLA ELALALDHLH QLGIVYRDLK
210 220 230 240 250
PENILLDEIG HIKLTDFGLS KESVDQEKKA YSFCGTVEYM APEVVNRRGH
260 270 280 290 300
SQSADWWSYG VLMFEMLTGT LPFQGKDRNE TMNMILKAKL GMPQFLSAEA
310 320 330 340 350
QSLLRMLFKR NPANRLGSEG VEEIKRHLFF ANIDWDKLYK REVQPPFKPA
360 370 380 390 400
SGKPDDTFCF DPEFTAKTPK DSPGLPASAN AHQLFKGFSF VATSIAEEYK
410 420 430 440 450
ITPITSANVL PIVQINGNAA QFGEVYELKE DIGVGSYSVC KRCIHATTNM
460 470 480 490 500
EFAVKIIDKS KRDPSEEIEI LMRYGQHPNI ITLKDVFDDG RYVYLVTDLM
510 520 530 540 550
KGGELLDRIL KQKCFSEREA SDILYVISKT VDYLHCQGVV HRDLKPSNIL
560 570 580 590 600
YMDESASADS IRICDFGFAK QLRGENGLLL TPCYTANFVA PEVLMQQGYD
610 620 630 640 650
AACDIWSLGV LFYTMLAGYT PFANGPNDTP EEILLRIGNG KFSLSGGNWD
660 670 680 690 700
NISDGAKDLL SHMLHMDPHQ RYTAEQILKH SWITHRDQLP NDQPKRNDVS
710 720 730 740
HVVKGAMVAT YSALTHKTFQ PVLEPVAASS LAQRRSMKKR TSTGL
Length:745
Mass (Da):83,872
Last modified:January 9, 2013 - v1
Checksum:i5EC5AB2FA1C19DE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC193009 Genomic DNA No translation available.
GABC01001391 mRNA Translation: JAA09947.1
GABF01005829 mRNA Translation: JAA16316.1
GABD01008908 mRNA Translation: JAA24192.1
GABE01010945 mRNA Translation: JAA33794.1
NBAG03000363 Genomic DNA Translation: PNI35018.1
RefSeqiXP_016799222.1, XM_016943733.1

Genome annotation databases

EnsembliENSPTRT00000041085; ENSPTRP00000037953; ENSPTRG00000022064
GeneIDi743327
KEGGiptr:743327

Similar proteinsi

Entry informationi

Entry nameiK7D2H3_PANTR
AccessioniPrimary (citable) accession number: K7D2H3
Secondary accession number(s): A0A2J8KJ14, H2QYU8
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: July 18, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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