Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CAPN10 isoform 1

Gene

CAPN10

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73PROSITE-ProRule annotation1
Active sitei238PROSITE-ProRule annotation1
Active sitei263PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation

Protein family/group databases

MEROPSiC02.018

Names & Taxonomyi

Protein namesi
Submitted name:
CAPN10 isoform 1Imported
Submitted name:
CAPN10 isoform 3Imported
Submitted name:
Calpain 10Imported
Gene namesi
Name:CAPN10Imported
ORF Names:CK820_G0052009Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 2B

Organism-specific databases

VGNCiVGNC:10626 CAPN10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSPTRG00000013108 Expressed in 6 organ(s), highest expression level in cerebellum

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000022437

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 317Calpain catalyticInterPro annotationAdd BLAST305

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00750000117668
KOiK08579
OMAiYEQLWAG
OrthoDBiEOG091G02O4
TreeFamiTF314748

Family and domain databases

CDDicd00214 Calpain_III, 2 hits
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR028791 CAPN10
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF30 PTHR10183:SF30, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 2 hits
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

K7CKA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAGRGATPA KELFRDATFP AADSSLFCDL STPLAQFRED ITWRRPQEIC
60 70 80 90 100
ATPRLFPDDP REGQVKQGLL GDCWFLCACA ALQKSRHLLE QVIPPGQPSW
110 120 130 140 150
ADQEYRGSFT CRIWQFGRWV EVTTDDRLPC LAGRLCFSRC QREDVFWLPL
160 170 180 190 200
LEKVYAKVHG SYEHLWAGQV ADALVDLTGG LAERWNLKGV AGSGGQQDRP
210 220 230 240 250
GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF IVSDLRELQG
260 270 280 290 300
QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE
310 320 330 340 350
FWVEEEEFVR EFDELTVGYP VTEAGRLQSL YTERLLCHTR ALPGAWVKGQ
360 370 380 390 400
SAGGCRNNSG FPSNPKFWLR VSEPSEVYIA VLQRSRPHAA DWAGRARALV
410 420 430 440 450
GDSHTSWSPA SIPGKHYQAV GLHLWKVEKR RVNLPRVLSM PPVAGTACHA
460 470 480 490 500
YDREVHLRCE LSPGYYLAVP STFLKDAPGE FLLRVFSTGR VSLSAIRAVA
510 520 530 540 550
KNTAPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT NPCFPFSVPE
560 570 580 590 600
GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL
610 620 630 640 650
LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS
660 670
IHSQEMLGQF LQEVSVMAVM KT
Length:672
Mass (Da):74,913
Last modified:January 9, 2013 - v1
Checksum:i430DD65159452745
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3S4Y8A0A2I3S4Y8_PANTR
CAPN10 isoform 10
CAPN10 CK820_G0052009
517Annotation score:
A0A2I3RII2A0A2I3RII2_PANTR
Calpain 10
CAPN10
653Annotation score:
A0A2I3SL37A0A2I3SL37_PANTR
CAPN10 isoform 4
CAPN10 CK820_G0052009
139Annotation score:
A0A2I3SHQ7A0A2I3SHQ7_PANTR
CAPN10 isoform 5
CAPN10 CK820_G0052009
138Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04066516 Genomic DNA No translation available.
GABC01008897 mRNA Translation: JAA02441.1
GABF01010054 mRNA Translation: JAA12091.1
GABD01010222 mRNA Translation: JAA22878.1
GABE01001728 mRNA Translation: JAA43011.1
NBAG03000554 Genomic DNA Translation: PNI15593.1
NBAG03000554 Genomic DNA Translation: PNI15594.1
RefSeqiXP_016806372.1, XM_016950883.1

Genome annotation databases

EnsembliENSPTRT00000024318; ENSPTRP00000022437; ENSPTRG00000013108
GeneIDi460069
KEGGiptr:460069

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04066516 Genomic DNA No translation available.
GABC01008897 mRNA Translation: JAA02441.1
GABF01010054 mRNA Translation: JAA12091.1
GABD01010222 mRNA Translation: JAA22878.1
GABE01001728 mRNA Translation: JAA43011.1
NBAG03000554 Genomic DNA Translation: PNI15593.1
NBAG03000554 Genomic DNA Translation: PNI15594.1
RefSeqiXP_016806372.1, XM_016950883.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000022437

Protein family/group databases

MEROPSiC02.018

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000024318; ENSPTRP00000022437; ENSPTRG00000013108
GeneIDi460069
KEGGiptr:460069

Organism-specific databases

CTDi11132
VGNCiVGNC:10626 CAPN10

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00750000117668
KOiK08579
OMAiYEQLWAG
OrthoDBiEOG091G02O4
TreeFamiTF314748

Gene expression databases

BgeeiENSPTRG00000013108 Expressed in 6 organ(s), highest expression level in cerebellum

Family and domain databases

CDDicd00214 Calpain_III, 2 hits
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR028791 CAPN10
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF30 PTHR10183:SF30, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 2 hits
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7CKA1_PANTR
AccessioniPrimary (citable) accession number: K7CKA1
Secondary accession number(s): A0A2J8IYJ2, H2QJQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: November 7, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again