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Protein
Submitted name:

Nestin

Gene

NES

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
NestinImported
Gene namesi
Name:NESImported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:1346 NES

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSPTRG00000001468 Expressed in 6 organ(s), highest expression level in cerebellum

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000002483

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 313IF rodInterPro annotationAdd BLAST306

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 46Sequence analysisAdd BLAST35
Coiled coili123 – 150Sequence analysisAdd BLAST28
Coiled coili218 – 245Sequence analysisAdd BLAST28
Coiled coili257 – 284Sequence analysisAdd BLAST28
Coiled coili543 – 566Sequence analysisAdd BLAST24
Coiled coili579 – 599Sequence analysisAdd BLAST21
Coiled coili625 – 645Sequence analysisAdd BLAST21
Coiled coili700 – 720Sequence analysisAdd BLAST21
Coiled coili744 – 764Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IRNV Eukaryota
ENOG410XZH4 LUCA
GeneTreeiENSGT00730000110953
KOiK07609
OMAiWGLEGRA
OrthoDBiEOG091G01X9
TreeFamiTF336633

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR031211 Nestin
PANTHERiPTHR23239 PTHR23239, 3 hits
PTHR23239:SF131 PTHR23239:SF131, 3 hits
PfamiView protein in Pfam
PF00038 Filament, 2 hits
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

K7CIK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGCMGEESF QMWELNRRLE AYLARVKALE EQNELLSAEL GGLRAQSADT
60 70 80 90 100
SWRARADDEL AALRALVDQR WREKHAAEVA RDNLAEELEG VAGRCQQLRL
110 120 130 140 150
VRERTTEEVA RNRRAVEAEK CARAWLSSQA AELERELEAL RVAHEEERVG
160 170 180 190 200
LNAQAACAPR CPAPPRGPPA PAPEVEELAR RLGEAWRGAV RGYQERVAHM
210 220 230 240 250
ETSLGQARER LGRAVQGARE GRLELQQLQA ERGGLQERRA ALEQRLEDRW
260 270 280 290 300
QERLRATEKF QLAVEALEQE KQGLQSQIAQ VLEGRQQLAH LKMSLSLEVA
310 320 330 340 350
TYRTLLEAEN SRLQTPGGGS KTSLSFQDPK LELQFPGTPE GRRLGSLLPV
360 370 380 390 400
LSPTSLPSPL PATLETPVPA FLKNQEFLQA RTPTLASTPI PPTPQAPSPA
410 420 430 440 450
ADAEIRAQDA PLSLLQTQGG RKQAPEPLRA EARVAIPASV LPGPEEPGGQ
460 470 480 490 500
RQEASTGQSP EDHASLAPPL SPDHSSLEAK DGESGGSRVF SICQGEGEGQ
510 520 530 540 550
IWGLVEKETA IEGKVVSSLQ QEIWEEEDVN RKEIQDSQVP LEKETLKSLG
560 570 580 590 600
EEIQESLKTL ENQSHETLER ENQECPRSLE EDLETLKSLE KENKELLKDV
610 620 630 640 650
EVVRPLEKEA VGQLKPTGKE DTQTLQSLQK ENQELMKSLE GNLETFLFPG
660 670 680 690 700
KENQELVSSL QENLESLTAL EKENQEPLRS PEVGDEEALR PLTKENQEPL
710 720 730 740 750
RSLEDENKEA FRSLEKENQE PLKTLEEEDQ SIVRPLETEN HKSLRSLEQQ
760 770 780 790 800
DQETLRTLEK ETQQRRRSLG EEDQMTLRPP EKVDPEPLKS LDQEIARPLE
810 820 830 840 850
NENQEFLKSL KEESVEAVKS LETEILESLK SAGQENLETL KSPETQAPLW
860 870 880 890 900
TPEEINQGTM KPLEKEIQEP LESVEVNQET LRLLEEENQE SLRSLGAWNL
910 920 930 940 950
ENLRSPEEVD KESQRNLEEE ENLGKGEYQE SLRSLEEEGQ ELPQSADVQR
960 970 980 990 1000
WEDTVEKDQE LAQESPPGMA GVENEDEAEL NLREQDGFTG KEEVVEQGEL
1010 1020 1030 1040 1050
NATEEVWIPG EGHPESPEPK EQRGLVEGAS VKGGAEGLQD PEGQSQQVVA
1060 1070 1080 1090 1100
PGLQAPQGLP EAIEPLVEDD VAPGGDQASP EVMLGSEPAM GESAAGAEPG
1110 1120 1130 1140 1150
PGQGVGGLED PGHLTREEVM EPPLEEESLE AKRVQGLEGP RKDLEEAGGL
1160 1170 1180 1190 1200
GTEFSELPGK SRDPWEPPKG REESEAEAPR GAEEAFPAET LGHTGSDAPS
1210 1220 1230 1240 1250
PWPLGSEEAE EDVPPVLVSP SPTYTPILED APGPQPQAEG SQEASWGVQG
1260 1270 1280 1290 1300
RAEALGKVES EQEELGSGEI PEGLQEEGEE SREESEEDEL GETLPDSTPL
1310 1320 1330 1340 1350
GFYLRSPTSP RWDPTGEQRP PPQGETGKEG WDPAVLASEG LEAPPSEKEE
1360 1370 1380 1390 1400
GEEGEEECGC DSDLSEEFED LGTEAPFLPG VPGEVAEPLG QVPQLLLDPA
1410 1420 1430 1440 1450
AWDRDGESDG FADEEESGEE GEEDQEEGRE PGAGRWGPGS SVGSLQALSS
1460 1470 1480 1490 1500
SQRGEFLESD SVSVSVPWDD SLRGAVAGAP KTALETESQD SAEPSGSEEE
1510 1520 1530 1540 1550
SDPVSLERED KVPGPLEIPS GMEDAGPGAD IIGVNGQGPN LEGKSQHVNG
1560 1570 1580 1590 1600
GVMNGLEQSE EVGQGMPLVS EGDRGSPFQE EEGSALKTSW AGAPVHLGQG
1610 1620
QFLKFTQREG DRESWSSGED
Length:1,620
Mass (Da):177,303
Last modified:January 9, 2013 - v1
Checksum:i022341A87BA17318
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3S018A0A2I3S018_PANTR
Nestin
NES
1,587Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04025361 Genomic DNA No translation available.
GABC01005701 mRNA Translation: JAA05637.1
GABF01003378 mRNA Translation: JAA18767.1
GABE01000155 mRNA Translation: JAA44584.1
RefSeqiXP_003308562.3, XM_003308514.3

Genome annotation databases

EnsembliENSPTRT00000002702; ENSPTRP00000002483; ENSPTRG00000001468
GeneIDi742303
KEGGiptr:742303

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04025361 Genomic DNA No translation available.
GABC01005701 mRNA Translation: JAA05637.1
GABF01003378 mRNA Translation: JAA18767.1
GABE01000155 mRNA Translation: JAA44584.1
RefSeqiXP_003308562.3, XM_003308514.3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000002483

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000002702; ENSPTRP00000002483; ENSPTRG00000001468
GeneIDi742303
KEGGiptr:742303

Organism-specific databases

CTDi10763
VGNCiVGNC:1346 NES

Phylogenomic databases

eggNOGiENOG410IRNV Eukaryota
ENOG410XZH4 LUCA
GeneTreeiENSGT00730000110953
KOiK07609
OMAiWGLEGRA
OrthoDBiEOG091G01X9
TreeFamiTF336633

Gene expression databases

BgeeiENSPTRG00000001468 Expressed in 6 organ(s), highest expression level in cerebellum

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR031211 Nestin
PANTHERiPTHR23239 PTHR23239, 3 hits
PTHR23239:SF131 PTHR23239:SF131, 3 hits
PfamiView protein in Pfam
PF00038 Filament, 2 hits
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7CIK9_PANTR
AccessioniPrimary (citable) accession number: K7CIK9
Secondary accession number(s): H2Q0A1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: November 7, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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