Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CHRNB1 isoform 1

Gene

CHRNB1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
CHRNB1 isoform 1Imported
Submitted name:
Cholinergic receptor nicotinic beta 1 subunitImported
Submitted name:
Cholinergic receptor, nicotinic, beta 1 (Muscle)Imported
Gene namesi
Name:CHRNB1Imported
ORF Names:CK820_G0036800Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:9235 CHRNB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei246 – 270HelicalSequence analysisAdd BLAST25
Transmembranei277 – 295HelicalSequence analysisAdd BLAST19
Transmembranei307 – 332HelicalSequence analysisAdd BLAST26
Transmembranei470 – 492HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501509589024 – 501Sequence analysisAdd BLAST478

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSPTRG00000008689 Expressed in 6 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000014815

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 245Neur_chan_LBDInterPro annotationAdd BLAST218
Domaini252 – 487Neur_chan_membInterPro annotationAdd BLAST236

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
OMAiFIDGPNR
OrthoDBiEOG091G0R20
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

K7C899-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPGALLMLL GALGAPLAPG VRGSEAEGRL REKLFSGYDS SVRPAREVGD
60 70 80 90 100
RVRVSVGLIL AQLISLNEKD EEMSTKVYLD LEWTDYRLSW DPAEHDGIDL
110 120 130 140 150
LRITAESVWL PDVVLLNNND GNFDVALDIS VVVSSDGSVR WQPPGIYRSS
160 170 180 190 200
CSIQVTYFPF DWQNCTMVFS SYSYDSSEVS LQTGLGPDRQ GHQEIHIHEG
210 220 230 240 250
TFIENGQWEI IHKPSRLIQP PGDPRGGREG QRQKVIFYLI IRRKPLFYLV
260 270 280 290 300
NVIAPCILIT LLAIFVFYLP PDAGEKMGLS IFALLTLTVF LLLLADKVPE
310 320 330 340 350
TSLSVPIIIK YLMFTMVLVT FSVILSVVVL NLHHRSPHTH QMPLWVRQIF
360 370 380 390 400
IHKLPLYLRL KRPKPERDLM PEPPHCSSPG SGWGRGTDEY FIRKPPSDFL
410 420 430 440 450
FPKPNRFQPE LSAPDLRRFI DGPNRAVALL PELREVVSSI SYIARQLQEQ
460 470 480 490 500
EDHDALKEDW QFVAMVVDRL FLWTFIIFTS VGTLVIFLDA TYHLPPPDPF

P
Length:501
Mass (Da):56,823
Last modified:January 9, 2013 - v1
Checksum:i2DFCB00F5009B77C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04040209 Genomic DNA No translation available.
GABE01005949 mRNA Translation: JAA38790.1
GABE01005948 mRNA Translation: JAA38791.1
NBAG03000347 Genomic DNA Translation: PNI36951.1
RefSeqiXP_511298.4, XM_511298.6

Genome annotation databases

EnsembliENSPTRT00000016011; ENSPTRP00000014815; ENSPTRG00000008689
GeneIDi454461

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04040209 Genomic DNA No translation available.
GABE01005949 mRNA Translation: JAA38790.1
GABE01005948 mRNA Translation: JAA38791.1
NBAG03000347 Genomic DNA Translation: PNI36951.1
RefSeqiXP_511298.4, XM_511298.6

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000014815

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000016011; ENSPTRP00000014815; ENSPTRG00000008689
GeneIDi454461

Organism-specific databases

CTDi1140
VGNCiVGNC:9235 CHRNB1

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
OMAiFIDGPNR
OrthoDBiEOG091G0R20
TreeFamiTF315605

Gene expression databases

BgeeiENSPTRG00000008689 Expressed in 6 organ(s), highest expression level in liver

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7C899_PANTR
AccessioniPrimary (citable) accession number: K7C899
Secondary accession number(s): A0A2J8KPM5, H2QC41
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: October 10, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again