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Protein

RNA polymerase II transcription factor B subunit 2

Gene

PHACADRAFT_171015

Organism
Phanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora carnosa)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:PHACADRAFT_171015Imported
OrganismiPhanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora carnosa)Imported
Taxonomic identifieri650164 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesPhanerochaetaceaePhanerochaete
Proteomesi
  • UP000008370 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

InParanoidiK5W1U7
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

K5W1U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVQQASTD SATASEAPSH LLLAFLQSQS QNTLTRLYQR PSSCLSIFRL
60 70 80 90 100
LGPLERQIVM NLLWLESSIP ASTMATWVPH EVRKTYENSL SILSRLHILP
110 120 130 140 150
QSAVKLALNP TFKTSLRHAI IGGGSSGSFG VPATRDEKHS SPSIEVLDAY
160 170 180 190 200
ALERWETILH YMVSSGIATR PSQGVLFLLQ RSGLMASIHG GSLQITSLGF
210 220 230 240 250
QFLLHSPHAQ LWELLLQYLH MVEERQMDLV EVLSFLFMLS TMELGREYSV
260 270 280 290 300
EHLSPTQTAM LEDLRDYGII WQRRATSKRF CPTRLATTLT SSSPPLPAAG
310 320 330 340 350
GVSASAHGQG FIILETNYRL YAYTDNPLQI AVLNLFVTLK SRYPNLVVGA
360 370 380 390 400
ITRESVKKAL TNGITADQAS RQIISYLTTH AHPQMRKNKP LLPVTVQDQI
410 420 430 440 450
RLWELEKNRM KSQEGYLYTA FASQADYEYV LNYAKQLGVV LWESSGRRCF
460 470
FGTLEGHPNI RGFIERRTAG NA
Length:472
Mass (Da):52,782
Last modified:January 9, 2013 - v1
Checksum:i980DCD36F9B0CF5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH930470 Genomic DNA Translation: EKM57798.1
RefSeqiXP_007393142.1, XM_007393080.1

Genome annotation databases

EnsemblFungiiEKM57798; EKM57798; PHACADRAFT_171015
GeneIDi18909539
KEGGipco:PHACADRAFT_171015

Similar proteinsi

Entry informationi

Entry nameiK5W1U7_PHACS
AccessioniPrimary (citable) accession number: K5W1U7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: March 28, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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