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Entry version 61 (02 Dec 2020)
Sequence version 1 (09 Jan 2013)
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Protein

3C-like proteinase

Gene

Pol1

Organism
Porcine epidemic diarrhea virus
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.ARBA annotation
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.ARBA annotation
Nsp9 is a ssRNA-binding protein.ARBA annotation
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.ARBA annotation
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.ARBA annotation
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ARBA annotation EC:3.4.19.12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseARBA annotation, ExonucleaseARBA annotation, HelicaseARBA annotation, Hydrolase, MethyltransferaseARBA annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase
Biological processActivation of host autophagy by virusARBA annotation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virusARBA annotation, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion, Viral RNA replicationARBA annotation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.4.19.12ARBA annotation, EC:3.6.4.12ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
ExoribonucleaseARBA annotation
Growth factor-like peptideARBA annotation
HelicaseARBA annotation
M-PROARBA annotation
NendoUARBA annotation
Non-structural protein 1ARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
ORF1ab polyproteinARBA annotation
PL1-PRO/PL2-PROARBA annotation
PLP1/PLP2ARBA annotation
Papain-like proteinases 1/2ARBA annotation
Peptide HD2ARBA annotation
Putative 2'-O-methyl transferaseARBA annotation
RNA-directed RNA polymeraseARBA annotation
Replicase polyprotein 1abARBA annotation
Uridylate-specific endoribonucleaseARBA annotation
nsp12ARBA annotation
nsp15ARBA annotation
nsp16ARBA annotation
nsp5ARBA annotation
p12ARBA annotation
p195ARBA annotation
p23ARBA annotation
p34ARBA annotation
p5ARBA annotation
p87ARBA annotation
p9ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pol1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPorcine epidemic diarrhea virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28295 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeAlphacoronavirusPedacovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000172504 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1964 – 1982HelicalSequence analysisAdd BLAST19
Transmembranei2025 – 2044HelicalSequence analysisAdd BLAST20
Transmembranei2104 – 2125HelicalSequence analysisAdd BLAST22
Transmembranei2132 – 2153HelicalSequence analysisAdd BLAST22
Transmembranei2165 – 2185HelicalSequence analysisAdd BLAST21
Transmembranei2528 – 2546HelicalSequence analysisAdd BLAST19
Transmembranei2787 – 2804HelicalSequence analysisAdd BLAST18
Transmembranei2859 – 2887HelicalSequence analysisAdd BLAST29
Transmembranei3337 – 3354HelicalSequence analysisAdd BLAST18
Transmembranei3361 – 3381HelicalSequence analysisAdd BLAST21
Transmembranei3401 – 3419HelicalSequence analysisAdd BLAST19
Transmembranei3431 – 3449HelicalSequence analysisAdd BLAST19
Transmembranei3469 – 3493HelicalSequence analysisAdd BLAST25
Transmembranei3500 – 3520HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer.

ARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
K4L9I6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1057 – 1296Peptidase C16InterPro annotationAdd BLAST240
Domaini1286 – 1465MacroInterPro annotationAdd BLAST180
Domaini1691 – 1951Peptidase C16InterPro annotationAdd BLAST261
Domaini2998 – 3299Peptidase C30InterPro annotationAdd BLAST302
Domaini5028 – 5111CV ZBDInterPro annotationAdd BLAST84
Domaini5275 – 5636(+)RNA virus helicase C-terminalInterPro annotationAdd BLAST362

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1011 – 1045DisorderedSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd18808, SF1_C_Upf1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.40.220.10, 2 hits
3.40.50.11580, 1 hit
3.90.70.90, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043609, CoV_NSP15_C
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR027352, CV_ZBD
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR009466, NSP14_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR009461, NSP16_CoV-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR011050, Pectin_lyase_fold/virulence
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR001205, RNA-dir_pol_C
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13087, AAA_12, 1 hit
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 2 hits
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 2 hits
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF51126, SSF51126, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 2 hits
PS51657, PSRV_HELICASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K4L9I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNQVTLAF ANDAEISAFG FCTASEAVSY YSEAAASGFM QCRFVSFDLA
60 70 80 90 100
DTVEGLLPED YVMVVVGTTK LSAYVDTFGS RPRNICGWLL FSNCNYFLEE
110 120 130 140 150
LELTFGRRGG NIVPVDQYMC GADGKPVLQE SEWEYTDFFA DSEDGQLNIA
160 170 180 190 200
GITYVKAWIV ERSDVSYASQ NLTSIKSITY CSTYEHTFPD GTAMKVARTP
210 220 230 240 250
KIKKTVVLSE PLATIYREIG SPFVDNGSDA RSIIKRPVFL HAFVKCKCGS
260 270 280 290 300
YHWTVGDWTS YVSTCCGFKC KPVLVASCSA TPGSVVVTRA GAGTGVKYYN
310 320 330 340 350
NMFLRHVADI DGLAFWRILK VQSKDDLACS GKFLEHHEEG FTDPCYFLND
360 370 380 390 400
SSIATKLKFD ILSGKFSDEV KQAIFAGHVV VGSAFVDIVD DALGQPWFIR
410 420 430 440 450
KLGDLASAAW EQLKAVVRGL NLLSDEVVLF GKRLSCATLS IVNGVFEFIA
460 470 480 490 500
EVPEKLAAAV TVFVNFLNEL FESACDCLKV GGKTFNKVGS YVLFDNALVK
510 520 530 540 550
LVKAKVRGPR QAGVCEVRYT SLVIGSTTKV VSKRVENANV NLVVVDEDVT
560 570 580 590 600
LNTTGRTVVV DGLAFFESDG FYRHLADVDV VIEHPVYKSA CELKPVFECD
610 620 630 640 650
PIPDFPMPVA ASVAELCVQT DLLLKNYNTP YKTYSCVVRG DKCCITCTLH
660 670 680 690 700
ITAPSYMEDA ANFVDLCTKN IGTAGFHEFY ITAHEQQDLQ GFVTTCCTMS
710 720 730 740 750
GFECFMPIIP QCPAVLEEID GGSIWRSFIT GLNTMWDFCK HLKVSFGLDG
760 770 780 790 800
IVVTVARKFK RLGALLAEMY NTYLSTVVEN LVLAGVSFKY YAASVPKIVL
810 820 830 840 850
GCCFHSVKSV LASVFQIPVQ AGIEKFKVFL NCVHPVVPRV IETSFVELEE
860 870 880 890 900
TTFKPPALNG SIAIVDGFAF YYDGTLYYPT DGNSVVPICF KKKGGGDVKF
910 920 930 940 950
SDEVSVRTID PVYKVSLEFE FESETIMAVL NKAVGNRIKV TGGWDDVVEY
960 970 980 990 1000
INVAIEVLKD HIDVPKYYIY DEEGGTDPNL PVMVSQWPLN DDTISQDLLD
1010 1020 1030 1040 1050
VEVVTDAPID FEGDEVDSSD PDKVADVANS EPEDDGPNVA PETNVESEVE
1060 1070 1080 1090 1100
EVAATLSFIK DTPSTVIKDP FAFDFASYGG LKVLRQSHNN CWVTSTLVQL
1110 1120 1130 1140 1150
QLLGIVDDPA MELFSAGRVG PMVRKCYESQ KAILGSLGDV SACLESLTKD
1160 1170 1180 1190 1200
LHTLKITCSV VCGCGTGERI YEGCAFRMTP TLEPFPYGAC AQCAQVLMHT
1210 1220 1230 1240 1250
FKSIVGTGIF CRDTTALSLD SLVVKPLCAA AFIGKDSGHY VTNFYDAAMA
1260 1270 1280 1290 1300
IDGYGRHQIK YDTLNTICVK DVNWTAPFVP DVEPVLEPVV KPFYSYKNVD
1310 1320 1330 1340 1350
FYQGDFSDLV KLPCDFVVNA ANENLSHGGG IAKAIDVYTK GMLQKCSNDY
1360 1370 1380 1390 1400
IKAHGSIKVG RGVMLDALGL KVFNVVGPRK GKHAPELLVK AYKSVFANSG
1410 1420 1430 1440 1450
VALTPLISVG IFSVPLEESL SAFLACVGDR HCKCFCYSDK EREAIINYMD
1460 1470 1480 1490 1500
GLVDAIFKDA LVDTTPVQED VQQVSQKPVL PNFEPFRIEG AHAFYECNPE
1510 1520 1530 1540 1550
GLMSLGADKL VLFTNSNLDF CSVGKCLNNV TGGALLEAIN VFKKSNKTVP
1560 1570 1580 1590 1600
AGNCVTFECA DMISITMVVL PSDGDANYDK NYARAVVKVS KLKGKLLLAV
1610 1620 1630 1640 1650
GDATLYSKLS HLSVIGFVST PDDVERFYAN KSVVIKVTED TRSVKAVKVE
1660 1670 1680 1690 1700
STVTYGQQIG PCLVNDTVVT DNKPVVADVV AKVVPSANWD SHYGFDKAGE
1710 1720 1730 1740 1750
FHMLYHTGFA FPSEVVNGRR VLKTTDNNCW VNVTCLQLQF ARFRFKSAGL
1760 1770 1780 1790 1800
QAMWESYCTG DVAMFVHWLY WLTGVDKGQP SDSENALNML SKYIVSAGSV
1810 1820 1830 1840 1850
TIERVTHDGC CCSKRVVTAP VVNASVLKLG VEDGLCPHGL NYIDKVVVVK
1860 1870 1880 1890 1900
GTTIVVNVGK PVVAPSHLFL KGVSYTTFLD NGNGVVGHYT VFDHDTGMVH
1910 1920 1930 1940 1950
DGDAFVPGDI NVSPVTNVVV SEQTAVVIKD PVKKVELDAT KLLDTMNYAS
1960 1970 1980 1990 2000
ERFFSFGDFM SRNLITVFLY ILSILGLCFR AFRKRDVKVL AGVPQRTGII
2010 2020 2030 2040 2050
LRKSVRYNAK ALGVFFKLKL YWFKVLGKFS LGIYALYALL FMTIRFTPIG
2060 2070 2080 2090 2100
GPVCDDVVAG YANSSFDKNE YCNSVICKVC LYGYQELSDF FHTQVVWQHL
2110 2120 2130 2140 2150
RDPLIGNVMP FFYLAFLAIF GGVYVKAITL YFIFQYLNIL GVFLGLQQSI
2160 2170 2180 2190 2200
WFLQLVPFDV FGDEIVVFFI VTRVLMFLKH VFLGCDKASC VACSKSARLK
2210 2220 2230 2240 2250
RVPVQTIFQG TSKSFYVHAN GGSKFCKKHN FFCLNCDSYG PGCTFINDVI
2260 2270 2280 2290 2300
AIEVGNVVKL NVQPTGPATI LIDKVEFSNG FYYLYSGDTF WKYNFDITDS
2310 2320 2330 2340 2350
KYTCKESLKN CSIITDFIVF NNNGSNVNQV KNACVYFSQM LCKPVKLVDS
2360 2370 2380 2390 2400
ALLASLSVDF GASLHSAFVS VLSNSFGKDL SSCNDMQDCK STLGFDDVPL
2410 2420 2430 2440 2450
DTFNAAVAEA HRYDVLLTDM SFNNFTTSYA KPEEKLPVHD IATCMRVGAK
2460 2470 2480 2490 2500
IVNHNVLVKD SIPVVWLVRD FIALSEETRK YIIRTTKVKG ITFMLTFNDC
2510 2520 2530 2540 2550
RMHTTIPTVC IANKKGAGLP SFSKVKKFFW FLCLFIVVVF FALSFLDFST
2560 2570 2580 2590 2600
QVSSDSDYDF KYIESGQLKT FDNPLSCVHN VFSNFDQWHD AKFGFTPVNN
2610 2620 2630 2640 2650
PSCPIVVGVS DEARTVPGIP AGVYLAGKTL VFAINTIFGT SGLCFDASGV
2660 2670 2680 2690 2700
ADKGACIFNS ACTTLSGLGG TAVYCYKNGL VEGAKLYSEL APHSYYKMVD
2710 2720 2730 2740 2750
GNAVSLPEII SRGFGIRTIR TKAMTYCRVG QCVQSAEGVC FGADRFFVYN
2760 2770 2780 2790 2800
AESGSDFVCG TGLFTLLMNV ISVFSKTVPV TVLSGQILFN CIIAFAAVAV
2810 2820 2830 2840 2850
CFLFTKFKRM FGDMSVGVFT VGACTLLNNV SYIVTQNTLG MLGYATLYFL
2860 2870 2880 2890 2900
CTKGVRYMWI WHLGFLISYI LIAPWWVLMV YAFSAIFEFM PNLFKLKVST
2910 2920 2930 2940 2950
QLFEGDKFVG SFENAAAGTF VLDMHAYERL ANSISTEKLR QYASTYNKYK
2960 2970 2980 2990 3000
YYSGSASEAD YRLACFAHLA KAMMDYASNH NDTLYTPPTV SYNSTLQAGL
3010 3020 3030 3040 3050
RKMAQPSGVV EKCIVRVCYG NMALNGLWLG DTVMCPRHVI ASSTTSTIDY
3060 3070 3080 3090 3100
DYALSVLRLH NFSISSGNVF LGVVGVTMRG ALLQIKVNQN NVHTPKYTYR
3110 3120 3130 3140 3150
TVRPGESFNI LACYDGAAAG VYGVNMRSNY TIRGSFINGA CGSPGYNINN
3160 3170 3180 3190 3200
GTVEFCYLHQ LELGSGCHVG SDLDGVMYGG YEDQPTLQVE GASSLFTENV
3210 3220 3230 3240 3250
LAFLYAALIN GSTWWLSSSR IAVDRFNEWA VHNGMTTVVN TDCFSILAAK
3260 3270 3280 3290 3300
TGVDVQRLLA SIQSLHKNFG GKQILGYTSL TDEFTTGEVI RQMYGVNLQS
3310 3320 3330 3340 3350
GYVSRACRNV LLVGSFLTFF WSELVSYTKF FWVNPGYVTP MFACLSLLSS
3360 3370 3380 3390 3400
LLMFTLKHKT LFFQVFLIPA LIVTSCINLA FDVEVYNYLA EHFDYHVSLM
3410 3420 3430 3440 3450
GFNAQGLVNI FVCFVVTILH GTYTWRFFNT PVSSVTYVVA LLTAAYNYFY
3460 3470 3480 3490 3500
ASDILSCAMT LFASVTGNWF VGAVCYKAAV YMALRFPTFV AIFGDIKSVM
3510 3520 3530 3540 3550
FCYLVLGYFT CCFYGILYWF NRFFKVSVGV YDYTVSAAEF KYMVANGLRA
3560 3570 3580 3590 3600
PTGTLDSLLL SAKLIGIGGE RNIKISSVQS KLTDIKCSNV VLLGCLSSMN
3610 3620 3630 3640 3650
VSANSTEWAY CVDLHNKINL CNDPEKAQEM LLALLAFFLS KNSAFGLDDL
3660 3670 3680 3690 3700
LESYFNDNSM LQSVASTYVG LPSYVIYENA RQQYEDAVNN GSPPQLVKQL
3710 3720 3730 3740 3750
RHAMNVAKSE FDREASTQRK LDRMAEQAAA QMYKEARAVN RKSKVVSAMH
3760 3770 3780 3790 3800
SLLFGMLRRL DMSSVDTILN LAKDGVVPLS VIPAVSATKL NIVTSDIDSY
3810 3820 3830 3840 3850
NRIQREGCVH YAGTIWNIID IKDNDGKVVH VKEVTAQNAE SLSWPLVLGC
3860 3870 3880 3890 3900
ERIVKLQNNE IIPGKLKQRS IKAEGDGIVG EGKALYNNEG GRTFMYAFIS
3910 3920 3930 3940 3950
DKPDLRVVKW EFDGGCNTIE LEPPRKFLVD SPNGAQIKYL YFVRNLNTLR
3960 3970 3980 3990 4000
RGAVLGYIGA TVRLQAGKQT EQAINSSLLT LCAFAVDPAK TYIDAVKRGH
4010 4020 4030 4040 4050
KPVGNCVKML ANGSGNGQAV TNGVEASTNQ DSYGGASVCL YCRAHVEHPS
4060 4070 4080 4090 4100
MDGFCRLKGK YVQVPLGTVD PIRFVLENDV CKVCGCWLAN GCTCDRSIMQ
4110 4120 4130 4140 4150
STDYGLFKRV RGSSAARLEP CNGTDTQHVY RAFDIYNKDV ACLGKFLKVN
4160 4170 4180 4190 4200
CVRLKNLDKH DAFYVVKRCT KSAMEHEQSI YSRLEKCGAV AEHDFFTWKD
4210 4220 4230 4240 4250
GRAIYGNVCR KDLTEYTMMD LCYALRNFDE NNCDVLKSIL IKVGACEESY
4260 4270 4280 4290 4300
FNNKVWFDPV ENEDIHRVYA LLGTIVSRAM LKCVKFCDAM VEQGIVGVVT
4310 4320 4330 4340 4350
LDNQDLNGDF YDFGDFTCSI KGMGIPICTS YYSYMMPVMG MTNCLASECF
4360 4370 4380 4390 4400
VKSDIFGEDF KSYDLLEYDF TEHKTSLFNK YFKYWGLQYH PNCVDCSDEQ
4410 4420 4430 4440 4450
CIVHCANFNT LFSTTIPITA FGPLCRKCWI DGVPLVTTAG YHFKQLGIVW
4460 4470 4480 4490 4500
NNDLNLHSSR LSINELLQFC SDPALLIASS PALVDQRTVC FSVAALGTGM
4510 4520 4530 4540 4550
TNQTVKPGHF NKEFYDFLLE QGFFSEGSEL TLKHFFFAQK GDAAVKDFDY
4560 4570 4580 4590 4600
YRYNRPTVLD ICQARVVYQI VQRYFDIYEG GCITAKEVVV TNLNKSAGYP
4610 4620 4630 4640 4650
LNKFGKAGLY YESLSYEEQD ELYAYTKRNI LPTMTQLNLK YAISGKERAR
4660 4670 4680 4690 4700
TVGGVSLLST MTTRQYHQKH LKSIVNTRGA SVVIGTTKFY GGWDNMLKNL
4710 4720 4730 4740 4750
IDGVENPCLM GWDYPKCDRA LPNMIRMISA MILGSKHTTC CSSTDRFFRL
4760 4770 4780 4790 4800
CNELAQVLTE VVYSNGGFYL KPGGTTSGDA TTAYANSVFN IFQAVSANVN
4810 4820 4830 4840 4850
KLLSVDSNVC HNLEVKQLQR KLYECCYRST TVDDQFVVEY YGYLRKHFSM
4860 4870 4880 4890 4900
MILSDDGVVC YNNDYASLGY VADLNAFKAV LYYQNNVFMS ASKCWIEPDI
4910 4920 4930 4940 4950
NKGPHEFCSQ HTMQIVDKDG TYYLPYPDPS RILSAGVFVD DVVKTDAVVL
4960 4970 4980 4990 5000
LERYVSLAID AYPLSKHENP EYKKVFYVLL DWVKHLYKTL NAGVLESFSV
5010 5020 5030 5040 5050
TLLEDSTAKF WDESFYANMY EKSAVLQSAG LCVVCGSQTV LRCGDCLRRP
5060 5070 5080 5090 5100
MLCTKCAYDH VIGTTHKFIL AITPYVCCAS DCGVNDVTKL YLGGLSYWCH
5110 5120 5130 5140 5150
EHKPRLAFPL CSAGNVFGLY KNSATGSPDV EDFNRIATSD WTDVSDYRLA
5160 5170 5180 5190 5200
NDVKDSLRLF AAETIKAKEE SVKSSYACAT LHEVVGPKEL LLKWEVGRPK
5210 5220 5230 5240 5250
PPLNRNSVFT CYHITKNTKF QIGEFVFEKA EYDNDAVTYK TTATTKLVPG
5260 5270 5280 5290 5300
MVFVLTSHNV QPLRAPTIAN QERYSTIHKL HPAFNIPEAY SSLVPYYQLI
5310 5320 5330 5340 5350
GKQKITTIQG PPGSGKSHCV IGLGLYYPGA RIVFTACSHA AVDSLCVKAS
5360 5370 5380 5390 5400
TAYSNDKCSR IIPQRARVEC YDGFKSNNTS AQYLFSTVNA LPECNADIVV
5410 5420 5430 5440 5450
VDEVSMCTNY DLSVINQRIS YRHVVYVGDP QQLPAPRVMI SRGTLEPKDY
5460 5470 5480 5490 5500
NVVTQRMCAL KPDVFLHKCY RCPAEIVRTV SEMVYENQFI PVHPDSKQCF
5510 5520 5530 5540 5550
KIFCKGNVQV DNGSSINRRQ LDVVRMFLAK NPRWSKAVFI SPYNSQNYVA
5560 5570 5580 5590 5600
SRMLGLQIQT VDSSQGSEYD YVIYTQTSDT AHACNVNRFN VAITRAKKGI
5610 5620 5630 5640 5650
LCIMCDRSLF DVLKFFELKL SDLQANEGCG LFKDCSRGDD LLPPSHANTF
5660 5670 5680 5690 5700
MSLADNFKTD QDLAVQIGVN GPIKYEHVIS FMGFRFDINI PNHHTLFCTR
5710 5720 5730 5740 5750
DFAMRNVRGW LGFDVEGAHV VGSNVGTNVP LQLGFSNGVD FVVRPEGCVV
5760 5770 5780 5790 5800
TESGDYIKPV RARAPPGEQF AHLLPLLKRG QPWDVVRKRI VQMCSDYLAN
5810 5820 5830 5840 5850
LSDILIFVLW AGGLELTTMR YFVKIGPSKS CDCGKVATCY NSALHTYCCF
5860 5870 5880 5890 5900
KHALGCDYLY NPYCIDIQQW GYKGSLSLNH HEHCNVHRNE HVASGDAIMT
5910 5920 5930 5940 5950
RCLAIHDCFV KNVDWSITYP FIGNEAVINK SGRIVQSHTM RSVLKLYNPK
5960 5970 5980 5990 6000
AIYDIGNPKG IRCAVTDAKW FCFDKNPTNS NVKTLEYDYI THGQFDGLCL
6010 6020 6030 6040 6050
FWNCNVDMYP EFSVVCRFDT RCRSPLNLEG CNGGSLYVNN HAFHTPAFDK
6060 6070 6080 6090 6100
RAFAKLKPMP FFFYDDTECD KLQDSINYVP LRASNCITKC NVGGAVCSKH
6110 6120 6130 6140 6150
CAMYHSYVNA YNTFTSAGFT IWVPTSFDTY NLWQTFSNNL QGLENIAFNV
6160 6170 6180 6190 6200
VKKGFFVGAE GELPVAVVND KVLVRDGTVD TLVFTNKTSL PTNVAFELYA
6210 6220 6230 6240 6250
KRKVGLTPPI TILRNLGVVC TSKCVIWDYE AERPLTTFTK DVCKYTDFEG
6260 6270 6280 6290 6300
DVCTLFDNSI VGSLERFSMT QNAVLMSLTA VKKLTGIKLT YGYLNGVPVN
6310 6320 6330 6340 6350
THEDKPFTWY IYTRKNGKFE DHPDGYFTQG RTTTDFSPRS DMEKDFLSMD
6360 6370 6380 6390 6400
MGLFINKYGL EDYGFEHVVY GDVSKTTLGG LHLLISQVRL ACMGVLKIDE
6410 6420 6430 6440 6450
FVSSNDSTLK SCTVTYADNP SSKMVCTYMD LLLDDFVSIL KSLDLGVVSK
6460 6470 6480 6490 6500
VHEVMVDCKM WRWMLWCKDH KLQTFYPQLQ ASEWKCGYSM PSIYKIQRMC
6510 6520 6530 6540 6550
LEPCNLYNYG AGIKLPDGIM FNVVKYTQLC QYLNSTTMCV PHHMRVLHLG
6560 6570 6580 6590 6600
AGSDKGVAPG TAVLRRWLPL DAIIVDNDSV DYVSDADYSV TGDCSTLYLS
6610 6620 6630 6640 6650
DKFDLVISDM YDGKIKSCDG ENVSKEGFFP YINGVITEKL ALGGTVAIKV
6660 6670 6680 6690 6700
TEFSWNKKLY ELIQKFEYWT MFCTSVNTSS SEAFLIGVHY LGDFASGAVI
6710 6720 6730 6740 6750
DGNTMHANYI FWRNSTIMTM SYNSVLDLSK FNCKHKATVV INLKDSSISD
6760 6770 6780
VVLGLLKNGK LLVRNNDAIC GFSNHLVNVN K
Length:6,781
Mass (Da):753,702
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i011E74C9A5164700
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JX489155 Genomic RNA Translation: AFV09313.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX489155 Genomic RNA Translation: AFV09313.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XFQX-ray1.65A/B2998-3295[»]
5XBCX-ray1.25A/B2-110[»]
6L70X-ray1.56A/B2998-3295[»]
SMRiK4L9I6
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

CDDicd18808, SF1_C_Upf1, 1 hit
Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.40.220.10, 2 hits
3.40.50.11580, 1 hit
3.90.70.90, 2 hits
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043609, CoV_NSP15_C
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR027352, CV_ZBD
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR009466, NSP14_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR009461, NSP16_CoV-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR011050, Pectin_lyase_fold/virulence
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR001205, RNA-dir_pol_C
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF13087, AAA_12, 1 hit
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 2 hits
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 2 hits
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF51126, SSF51126, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 2 hits
PS51657, PSRV_HELICASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK4L9I6_9ALPC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K4L9I6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: December 2, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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