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Entry version 33 (05 Jun 2019)
Sequence version 2 (28 Mar 2018)
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Protein
Submitted name:

Myosin V

Gene

Myo5

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi165 – 172ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin VImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 62Myosin N-terminal SH3-likeInterPro annotationAdd BLAST53
Domaini71 – 766Myosin motorInterPro annotationAdd BLAST696
Domaini1558 – 1834DiluteInterPro annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni601 – 637DisorderedSequence analysisAdd BLAST37
Regioni646 – 668Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni1100 – 1149DisorderedSequence analysisAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili925 – 952Sequence analysisAdd BLAST28
Coiled coili967 – 1054Sequence analysisAdd BLAST88
Coiled coili1157 – 1184Sequence analysisAdd BLAST28
Coiled coili1203 – 1233Sequence analysisAdd BLAST31
Coiled coili1338 – 1390Sequence analysisAdd BLAST53
Coiled coili1436 – 1463Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi601 – 625PolarSequence analysisAdd BLAST25
Compositional biasi1100 – 1120PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1121 – 1135PolarSequence analysisAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15478 Myo5a_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037988 Myo5a_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 5 hits
PF00063 Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 6 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K4JEU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENNLDFAYV THARVWIPDP EEVWKSAEML KDYKPGDTVL RLRLEEGTDL
60 70 80 90 100
EYRLDAKTKE LPPLRNPDIL VGENDLTALS YLHEPAVLHN LKVRFIDSKL
110 120 130 140 150
IYTYCGIVLV AINPYEQLPI YGTDIINAYS GQNMGDMDPH IFAVAEEAYK
160 170 180 190 200
QMARDERNQS IIVSGESGAG KTVSAKYAMR YFATVSGSAS ETNVEEKVLA
210 220 230 240 250
SNPIMESIGN AKTTRNDNSS RFGKYIEIGF DKRYRILGAH MRTYLLEKSR
260 270 280 290 300
VVFQAEEERN YHIFYQLCAS ASLPEFKMLR LGTANDFHYT KQGGSPVIDG
310 320 330 340 350
VDDQKEMRNT RQACTLLGIG ESYQMGIFRI LAAILHLGNV EFKSRDSDSC
360 370 380 390 400
LIPPKHVPLT IFCDLMGVDY EEMSHWLCHR KLVTAAETYI KPISRLQATN
410 420 430 440 450
ARDALAKHIY AFLFNWIVCH VNKALLSSTK QNSFIGVLDI YGFETFEINS
460 470 480 490 500
FEQFCINYAN EKLQQQFNLH VFKLEQEEYM KEQIPWTLID FYDNQPCINL
510 520 530 540 550
IEAKMGILDL LDEECKMPKG SDSTWAQKLY NTHLKKCALF EKPRLSNVAF
560 570 580 590 600
IIKHFADKVE YQCDGFLEKN KDTVFEEQIK VLKASKFTLL TELFQDEERI
610 620 630 640 650
LSPTSSAPPS GRTLLSRTSL RSLKPKPDQT SKEHKKTVGH QFRNSLHLLM
660 670 680 690 700
ETLNATTPHY VRCVKPNDFK YPFTFDSKRA VQQLRACGVL ETIRISAAGF
710 720 730 740 750
PSRWTYQEFF SRYRVLMKQK DVLSDWKQTC RNVLEKLILD KDKYQFGKTK
760 770 780 790 800
IFFRAGQVAY LEKIRADKLR MACIRIQKTI RGWLLRKKYL RMRKAAITIQ
810 820 830 840 850
RYVRGYQARC YAQFLRRTRA AIIIQKFQRM YVVRQKYRHI QSFTLALQSY
860 870 880 890 900
LRGYAARKRY QEILRAHKAT IIQKHVRGWL ARVTYKRNLS AIVYLQCRYR
910 920 930 940 950
RMMAKRELKK LKIEARSVEH FKKLNVGMEN KIMQLQCKVN DQNKDNKSLL
960 970 980 990 1000
ERLTHLEVTY NADKDKLRND VDRLRHFEEE AKNAANRMVS LQDELARLRK
1010 1020 1030 1040 1050
ELLQTQTEKN NIKERAEKYQ TETDRLVAEL REQNALLKTE KEKLNLLIQE
1060 1070 1080 1090 1100
QARKMTEDME KKIIEETKQL ELELNDERLR YQNLLNEYSR LEERYDDLKD
1110 1120 1130 1140 1150
EMNTMSPPKP GHKRTDSTHS SNESEYTFSS EITESEDFPY RNEEPADRKT
1160 1170 1180 1190 1200
PLDMSLFLKL QKRVKELEQE KQLMQDDLDK KEEQIIRAKI LEEAKTPTRG
1210 1220 1230 1240 1250
TELEYESLKR QELESENKKL KNELNELRKA ITEKASPDAK GPGGNVYHIL
1260 1270 1280 1290 1300
LEQMTSVSEE LDVRKEEVLI LRSQLVSQME AIPHKDTMTD SMVLSEDVQK
1310 1320 1330 1340 1350
MKDKREIAQA YTGMKETNRN LPPDFQDLNE DGELWLVYDG LKQANRVLES
1360 1370 1380 1390 1400
QLQSQKKAFE NEVEALRGEI QALKEENNRQ QQLLAQNLQL PPEARIEASL
1410 1420 1430 1440 1450
QHEITRLTNE NLFFEELYAD EPMKYQSYRI SLYRRIIDLM EQLEKQDKTV
1460 1470 1480 1490 1500
RKLKKQLKVF AKKIGELEVG QMENVSPGQI VDEPIRPVNI PRKEKDFQGM
1510 1520 1530 1540 1550
LEYKKEDELK LVKNLILELK PRGVAVNLIP GLPAYILFMC LRHADYLNDD
1560 1570 1580 1590 1600
QKVRSLLTST INGVKKILKK RGDDFETVSF WLSNTCRFLH CLKQYSGEEG
1610 1620 1630 1640 1650
FMKHNSPRQN EHCLTNFDLA EYRQVLSDLA IQIYQQLVRV LENILQPMIV
1660 1670 1680 1690 1700
SGMLEHETIQ GVSGVKPTGL RKRTSSIADE GTYTLDSIVR QLNTFHSIMC
1710 1720 1730 1740 1750
QHGMDPELIK QVVKQMFYII GAVTLNNLLL RKDMCSWSKG MQIRYNVSQL
1760 1770 1780 1790 1800
EEWLRDKNLM NSSAKETLEP LIQAAQLLQV KKKTDEDAEA ICSMCNALTT
1810 1820 1830 1840 1850
AQIVKVLNLY TPVNEFEERV LVSFIRNIQM RFRDRKDSPQ LLMDAKHIFP
1860 1870
VTFPFNPSSL ALETIQIPGS LGLGFLTRV
Length:1,879
Mass (Da):218,849
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CF246005DE2F4CF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX494698 mRNA Translation: AFU81219.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX494698 mRNA Translation: AFU81219.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd15478 Myo5a_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037988 Myo5a_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 5 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 6 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK4JEU1_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K4JEU1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: March 28, 2018
Last modified: June 5, 2019
This is version 33 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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