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Protein

L-lactate dehydrogenase

Gene

101263923

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh), L-lactate dehydrogenase (101263923), L-lactate dehydrogenase (ldh2), L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Active sitei207Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:101263923Imported
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)Imported
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 8

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiK4CIM9

Expressioni

Gene expression databases

ExpressionAtlasiK4CIM9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc08g007420.2.1

Structurei

3D structure databases

ProteinModelPortaliK4CIM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 174Ldh_1_NInterPro annotationAdd BLAST140
Domaini177 – 340Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
InParanoidiK4CIM9
KOiK00016
OMAiVDELVIC
OrthoDBiEOG09360DKP

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

K4CIM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSSSLSLD GLELNQVFFK SIANSNPPSQ TNHHTKISVI GVGNVGMAIA
60 70 80 90 100
QTILTQDLVD ELALVDANSD KLRGEMLDLQ HAAAFLPRTK IVASADYTVT
110 120 130 140 150
AGSDLCIVTA GARQNPGESR LNLLQRNLAM YKSIVPELVK YSPECILLIV
160 170 180 190 200
SNPVDVLTYV AWKLSGFPVN RVIGSGTNLD SSRFRFLIAD HLDVNAQDVQ
210 220 230 240 250
AYIVGEHGDS SVALWSSISV GGIPVLSFLE NQQIAFEKDT LEKIHKQVVQ
260 270 280 290 300
SAYEVINLKG YTSWAIGYSV ANLAFSIIRD QRRIHPVSIL AKGFYGIDGG
310 320 330 340
DVFLSLPAQL GRNGVLGVTN VHLTDEEIQQ LRNSAETILE VQNQLGI
Length:347
Mass (Da):37,645
Last modified:November 28, 2012 - v1
Checksum:i78AB93DDA6A06661
GO

Sequence databases

RefSeqiNP_001266020.2, NM_001279091.2
UniGeneiLes.96

Genome annotation databases

EnsemblPlantsiSolyc08g007420.2.1; Solyc08g007420.2.1; Solyc08g007420.2
GeneIDi101263923
GrameneiSolyc08g007420.2.1; Solyc08g007420.2.1; Solyc08g007420.2
KEGGisly:101263923

Similar proteinsi

Entry informationi

Entry nameiK4CIM9_SOLLC
AccessioniPrimary (citable) accession number: K4CIM9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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