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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

101260600

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotationSAAS annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei142S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei145UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotation, RNA-binding, Transferase, tRNA-bindingUniRule annotationSAAS annotation
Biological processtRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:101260600Imported
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)Imported
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiK4B7J7

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc02g068650.1.1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 90S-adenosyl-L-methionine bindingUniRule annotation2
Regioni122 – 123S-adenosyl-L-methionine bindingUniRule annotation2
Regioni220 – 222S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3115 Eukaryota
COG0220 LUCA
InParanoidiK4B7J7
KOiK03439
OMAiIGMEIRV
OrthoDBiEOG09360OC8

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

K4B7J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGENHTHNKK TGLPRKRFYR ARAHSNPLSD SHFPIPISPC EVDYSLHYPE
60 70 80 90 100
VVKVDPCKRI EFADVGCGFG GLLIALAPLF PDNLMIGMEL RDKVTEYVKE
110 120 130 140 150
RILGLRTTNS GQYQNISVVR TNSMKYIPNY FEKGQLKKMF FLFPDPHFKE
160 170 180 190 200
KNHRRRVISP FLLDEYAYVL AVGGIIYTIT DVEELGEWMK SCLEEHPMFE
210 220 230 240
ALTSEELEAD QVVKLLSAAT EEGQKVARNG GQTFRAVFRR IVTH
Length:244
Mass (Da):27,983
Last modified:November 28, 2012 - v1
Checksum:i5A415481880DB68B
GO

Sequence databases

RefSeqiXP_004233249.1, XM_004233201.3
UniGeneiLes.18669

Genome annotation databases

EnsemblPlantsiSolyc02g068650.1.1; Solyc02g068650.1.1; Solyc02g068650.1
GeneIDi101260600
GrameneiSolyc02g068650.1.1; Solyc02g068650.1.1; Solyc02g068650.1
KEGGisly:101260600

Similar proteinsi

Entry informationi

Entry nameiK4B7J7_SOLLC
AccessioniPrimary (citable) accession number: K4B7J7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: May 23, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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