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Entry version 55 (31 Jul 2019)
Sequence version 1 (28 Nov 2012)
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Protein
Submitted name:

Cytoskeleton-associated protein 5

Gene

Ckap5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cytoskeleton-associated protein 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ckap5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923036 Ckap5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040549 Expressed in 290 organ(s), highest expression level in submandibular gland

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 227TOGInterPro annotationAdd BLAST227
Domaini269 – 506TOGInterPro annotationAdd BLAST238
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati440 – 478HEATPROSITE-ProRule annotationAdd BLAST39
Domaini586 – 818TOGInterPro annotationAdd BLAST233
Domaini850 – 1082TOGInterPro annotationAdd BLAST233
Domaini1191 – 1429TOGInterPro annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni501 – 579DisorderedSequence analysisAdd BLAST79
Regioni811 – 848DisorderedSequence analysisAdd BLAST38
Regioni1078 – 1156DisorderedSequence analysisAdd BLAST79
Regioni1420 – 1459DisorderedSequence analysisAdd BLAST40
Regioni1801 – 1822DisorderedSequence analysisAdd BLAST22
Regioni1893 – 1926DisorderedSequence analysisAdd BLAST34
Regioni1948 – 2032DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi501 – 517PolyampholyteSequence analysisAdd BLAST17
Compositional biasi811 – 828PolarSequence analysisAdd BLAST18
Compositional biasi1437 – 1451PolarSequence analysisAdd BLAST15
Compositional biasi1897 – 1926PolarSequence analysisAdd BLAST30
Compositional biasi1982 – 1997PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1998 – 2017PolarSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1820 Eukaryota
ENOG410XPTW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014757

Database of Orthologous Groups

More...
OrthoDBi
33681at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105639

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348 CLASP_N, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

K3W4R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDDSEWLKL PVDQKCEHKL WKARLSGYEE ALKIFQKIKD EKSPEWSKYL
60 70 80 90 100
GLIKKFVTDS NAVVQLKGLE AALVYVENAH VAGKTTGEVV SGVVSKVFNQ
110 120 130 140 150
PKAKAKELGI EICLMYVEIE KGESVQEELL KGLDNKNPKI IVACIETLRK
160 170 180 190 200
ALSEFGSKII SLKPIIKVLP KLFESRDKAV RDEAKLFAIE IYRWNRDAVK
210 220 230 240 250
HTLQNINSVQ LKELEEEWVK LPTGAPKPSR FLRSQQELEA KLEQQQSAGG
260 270 280 290 300
DAEGGGDDGD EVPQVDAYEL LDAVEILSKL PKDFYDKIEA KKWQERKEAL
310 320 330 340 350
EAVEVLVKNP KLEAGDYADL VKALKKVVGK DTNVMLVALA AKCLTGLAVG
360 370 380 390 400
LRKKFGQYAG HVVPTILEKF KEKKPQVVQA LQEAIDAIFL TTTLQNISED
410 420 430 440 450
VLAVMDNKNP TIKQQTSLFI ARSFRHCTSS TLPKSLLKPF CAALLKHIND
460 470 480 490 500
SAPEVRDAAF EALGTALKVV GEKSVNPFLA DVDKLKLDRI KECSEKVELV
510 520 530 540 550
HGKKSGLATE KKESKPLPGR AAASGAAGDK DTKDVSGPKP GPLKKTPTAK
560 570 580 590 600
AGGPSKKGKT TAPGGSASAG TKNKKGLETK EIVEPELSIE VCEEKASAVL
610 620 630 640 650
PPTCIQLLDS SNWKERLACM EEFQKAVELM ERTEMPCQAL VKMLAKKPGW
660 670 680 690 700
KETNFQVMQM KLHIVALIAQ KGNFSKTSAQ IVLDGLVDKI GDVKCGNNAK
710 720 730 740 750
EAMTAIAEAC MLPWTAEQVM SMAFSQKNPK NQSETLNWLS NAIKEFGFSE
760 770 780 790 800
LNVKAFISNV KTALAATNPA VRTSAITLLG VMYLYVGPSL RMIFEDEKPA
810 820 830 840 850
LLSQIDAEFQ KMQGQSPPAP TRGIAKHSTS ATDEGEDGEE PGEGGNDVVD
860 870 880 890 900
LLPRIEISDK ITSELVSKIG DKNWKIRKEG LDEVAGIINE AKFIQPNIGE
910 920 930 940 950
LPTALKGRLN DSNKILVQQT LNILQQLAVA MGANIRQHVK NLGIPVITVL
960 970 980 990 1000
GDSKNNVRAA ALATVNAWAE QTGMKEWLEG EDLSEELKKE NPFLRQELLG
1010 1020 1030 1040 1050
WLAEKLPTLR STPTDLILCV PHLYSCLEDR NGDVRKKAQD ALPFFMMHLG
1060 1070 1080 1090 1100
YEKMAKATGK LKPTSKDQVL AMLEKAKANM PSKPAAPAKA MSKPMGGSAP
1110 1120 1130 1140 1150
AKTQPIPAPV EDSVSSTIEA KPDLKKAKAP GVSSKAKSVQ GKKVPSKTTL
1160 1170 1180 1190 1200
KEDDDKSGPI FIVVPNGKEQ RMRDEKGLKV LKWNFTTPRD EYIEQLKTQM
1210 1220 1230 1240 1250
STCVAKWLQD EMFHSDFQHH NKALAVMVDH LESEKDGVIS CLDLILKWLT
1260 1270 1280 1290 1300
LRFFDTNTSV LMKALEYLKL LFTLLSEEEY HLTENEASSF IPYLILKVGE
1310 1320 1330 1340 1350
PKDVIRKDVR AILNRMCLVY PASKMFPFIM EGTKSKNSKQ RAECLEELGC
1360 1370 1380 1390 1400
LIESYGMNVC QPTPGKALKE IAIHIGDRDN AVRNAALNTI VTVYNVHGDQ
1410 1420 1430 1440 1450
VFKLIGNLSE KDMSMLEERI KRSAKRPSAA PVKQAEEKPQ RTQNINSNAN
1460 1470 1480 1490 1500
MLRKGPAEDM SSKLNQARSL SGHPEAAQMV RREFQLDLDE IENDNGTVRC
1510 1520 1530 1540 1550
EMPELVQHKL DDIFEPVLIP EPKIRAVSPH FDDMHSNTAS TINFIISQVA
1560 1570 1580 1590 1600
SGDINTSIQA LTQIDEVLRQ EDKAEAMSGH IDQFLIATFM QLRLIYSTHM
1610 1620 1630 1640 1650
ADEKLDKDEI IKLYSCIIGN MISLFQIESL AREASTGVLK DLMHGLITLM
1660 1670 1680 1690 1700
LDSRIEDLEE GQQVIRSVNL LVVKVLEKSD QTNILSALLV LLQDSLLATA
1710 1720 1730 1740 1750
SSPKFSELVM KCLWRMVRLL PDTINSINLD RILLDIHIFM KVFPKEKLKQ
1760 1770 1780 1790 1800
CKSEFPIRTL KTLLHTLCKL KGPKILDHLT MIDNKNESEL EAHLCRMMKH
1810 1820 1830 1840 1850
SMDQTGSKSD KETEKGASRI DEKSSKAKVN DFLAEIFKKI GSKENTKEGL
1860 1870 1880 1890 1900
AELYEYKKKY SDTDIEPFLK NSSQFFQSYV ERGLRVIEME RESKGRIPTS
1910 1920 1930 1940 1950
TGISPQMEVT CVPTPTSTVS SLGNTNGEEV GPSVYLERLK ILRQRCGLDN
1960 1970 1980 1990 2000
TKQDDRPPLT SLLSKPAIPP VASSTDMLHS KLSQLRESRE QHQHSDLDSN
2010 2020 2030
QTHSAGTMTS SSSTTNIDDL KKRLERIKSS RK
Length:2,032
Mass (Da):225,636
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92572C826CB15CBA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AGT5CKAP5_MOUSE
Cytoskeleton-associated protein 5
Ckap5
2,032Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J0K2A0A0R4J0K2_MOUSE
Cytoskeleton-associated protein 5
Ckap5
2,011Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YL78Z4YL78_MOUSE
Cytoskeleton-associated protein 5
Ckap5
1,972Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL691489 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001159461.1, NM_001165989.1
XP_006500407.1, XM_006500344.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000099716; ENSMUSP00000097303; ENSMUSG00000040549
ENSMUST00000111338; ENSMUSP00000106970; ENSMUSG00000040549

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
75786

UCSC genome browser

More...
UCSCi
uc008kwe.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691489 Genomic DNA No translation available.
RefSeqiNP_001159461.1, NM_001165989.1
XP_006500407.1, XM_006500344.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099716; ENSMUSP00000097303; ENSMUSG00000040549
ENSMUST00000111338; ENSMUSP00000106970; ENSMUSG00000040549
GeneIDi75786
UCSCiuc008kwe.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9793
MGIiMGI:1923036 Ckap5

Phylogenomic databases

eggNOGiKOG1820 Eukaryota
ENOG410XPTW LUCA
GeneTreeiENSGT00390000014757
OrthoDBi33681at2759
TreeFamiTF105639

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040549 Expressed in 290 organ(s), highest expression level in submandibular gland

Family and domain databases

Gene3Di1.25.10.10, 5 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG
PfamiView protein in Pfam
PF12348 CLASP_N, 3 hits
SMARTiView protein in SMART
SM01349 TOG, 5 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK3W4R5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K3W4R5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 31, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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