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Entry version 37 (10 Feb 2021)
Sequence version 1 (28 Nov 2012)
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Protein
Submitted name:

Neuron navigator 2

Gene

CGI_10023552

Organism
Crassostrea gigas (Pacific oyster) (Crassostrea angulata)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00232

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neuron navigator 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CGI_10023552Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCrassostrea gigas (Pacific oyster) (Crassostrea angulata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaBivalviaAutobranchiaPteriomorphiaOstreidaOstreoideaOstreidaeCrassostrea
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005408 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

MitochondrionARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
K1QVV9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini498 – 651AAAInterPro annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni50 – 71DisorderedSequence analysisAdd BLAST22
Regioni122 – 143DisorderedSequence analysisAdd BLAST22
Regioni165 – 214DisorderedSequence analysisAdd BLAST50
Regioni322 – 341DisorderedSequence analysisAdd BLAST20
Regioni811 – 830DisorderedSequence analysisAdd BLAST20
Regioni1431 – 1455DisorderedSequence analysisAdd BLAST25
Regioni1778 – 1849DisorderedSequence analysisAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili280 – 314Sequence analysisAdd BLAST35
Coiled coili1910 – 1930Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 71PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1778 – 1831PolarSequence analysisAdd BLAST54
Compositional biasi1832 – 1849AcidicSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COQ9 family.ARBA annotation
Belongs to the Nav/unc-53 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, Transit peptideARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_232732_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR016024, ARM-type_fold
IPR003959, ATPase_AAA_core
IPR013718, COQ9
IPR039041, Nav/unc-53
IPR027417, P-loop_NTPase
IPR012762, Ubiq_biosynth_COQ9
IPR013877, YAP-bd/ALF4/Glomulin

The PANTHER Classification System

More...
PANTHERi
PTHR12784, PTHR12784, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit
PF08511, COQ9, 1 hit
PF08568, Kinetochor_Ybp2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02396, diverge_rpsU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K1QVV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPSKDNMQE KSEYESLYDS AGNEGYMAHV VAAFEQSLSN MTARLQHLTS
60 70 80 90 100
TAEQKASDKV RLRSKQEKDS ELNELRATIE ALKRQSGLSI PDPTILSPGA
110 120 130 140 150
GRRHTSPGMV NTNDYISSPL HQIHHQSPHH GNRPGFNTLP MPTEGRITRQ
160 170 180 190 200
LSTDSVSSIN SLSSACSTAS QQSAATDGEA GRRKKKKGWL RSSFSKAFSR
210 220 230 240 250
KKNKSGSMSD CELDMGNSRP NFSAPNSPLL QIHMPNGQGL IKGSHSSSAL
260 270 280 290 300
YEAEDASSVL ELKKQLRDKD MKLTDIRLEA LSSAHQLEQL RETMNKMKNE
310 320 330 340 350
MSALKADNDR LQRMMHVRPL NSSQNSIAHN RTSSESLERS LSITEQPSLE
360 370 380 390 400
MLLSETPDRD GKRVTMTVYL GSNPDPLREG VERPAEVLIG SLSVSGKTKW
410 420 430 440 450
DILDNIVRKI LKEYVLRVDP VTNLGLSAES VFSYHIAEII RTKDAELPEL
460 470 480 490 500
LPIGYLVGDT MQIGICLKGT RQNSVDSLAF ETLIPKSIVQ RYVSLLLEHR
510 520 530 540 550
RIILCGPSGT GKTYLAQKLA EHLVLRSGKE LTAGSVATFN VDHKSAKELR
560 570 580 590 600
QYLANIAEQC ENTGVGELPS VIILDNLHHV GSLGEVFNGF LSVKYQKCPY
610 620 630 640 650
IIGTMNQATC STTNLQLHHN FRWVLCANHM EPVKGFLGRY LRRKLVEAEV
660 670 680 690 700
RTGIRNNDLN KIIDWVPKVW LHLNKFLETH SSSDVTIGPR LFLSCPMEIS
710 720 730 740 750
GSKVWFTDLW NYSIVPYLLE AVREGLQVYG KRAPWEDPTD WVLESYPWAT
760 770 780 790 800
AKDEDPSLLK IRPEDVGYDT QGVISTSSGV ALKSKSSDST NHMEPSTDPL
810 820 830 840 850
YNMIKRLQEA ANYSSSQSGQ DDDSASATTQ ECISRHGLTF EIYSNQTQIE
860 870 880 890 900
RRNRGRTSGQ VQRDLLQSTP SWVARFTKFP LQRKAPMDQP MQVKLLKNKE
910 920 930 940 950
RRVVEMEELL KYQSETQTKK IKLQMTGVFE ELMTFHVQKN IQKNKERMDE
960 970 980 990 1000
VLQELMTFHD EQKMIINRRQ MRGVFKELKM YHSQQKIRTS KKLMARVFAE
1010 1020 1030 1040 1050
LTTFHAQQRT MQIKEKMRQV CAELMTIHAQ RETQTQTQKV MKRMQLVFAE
1060 1070 1080 1090 1100
LLQTNSERKK LKLLEEEGYE EFVPRKLFFF NIISFKQTDD DHLRQGPIYP
1110 1120 1130 1140 1150
DLSSPVALSK LAPPQESLDA KAAVVDDEND DEEMDKMEVA FKTKTTPLSY
1160 1170 1180 1190 1200
SHNHHFINIM DHLMDVEVME KAADAETALK QVKECIKFKD SKGLKTVILE
1210 1220 1230 1240 1250
HKLKDQSVFW EIASELTANL TEENLEQHEY FFETCQRCMN YVIANGNPKE
1260 1270 1280 1290 1300
LLLAVLEQAD SFKDDQKFKC ILENVQKILL KLPSKRHHSL DVTLETLSAH
1310 1320 1330 1340 1350
IEAIPQAKDH NLDHEERKLL EMDPSVMRAT DVVLCYLEFL SPFVEEVSMR
1360 1370 1380 1390 1400
NPKVTFSKST PQVQLLVKYL MKLLCHPLYH LDMTFKPKEQ EEKEKSYSRV
1410 1420 1430 1440 1450
CAERLIDQLA QLCPNFFALI EDETKKRSMQ AKLKESEARE DEENEELEEE
1460 1470 1480 1490 1500
EGDDKVKDWK EDKLIPEKSL ACLSYLVLAE GLGLDQMPAV YNHKFMLRFH
1510 1520 1530 1540 1550
LPFIKSFLED QHSIVKLKGV LLLEKLMFVI LPMSFTHYEL DNDFYKDILN
1560 1570 1580 1590 1600
LLISTMTHCQ NKDIRKSCVP IYSNFFGMFS LQGRHRLYET VFNTCKHSGV
1610 1620 1630 1640 1650
VGHTLSLYKE QVDSLLKKGE GPENIFLGKN LIRVFKLVSV IPDGVTTDLL
1660 1670 1680 1690 1700
ENSDRILSVL NFVRYLVLRD NPSENRTGFW ELYPNLDKEF FEPLRQAIIL
1710 1720 1730 1740 1750
SKGHYNLDLE DVRKGNPLPT ENTEFSVNVG GERLGPVSRE QQIQVIESAL
1760 1770 1780 1790 1800
NTFDMMDSIL SRTIELADAQ KRTLSRCNRN GGRFMCTSTG DRNPPMDTSS
1810 1820 1830 1840 1850
GPGGSASSQT SNGGYNTQRT GQGAQYSDEL DNSEDLVNEV EEEEMPEETE
1860 1870 1880 1890 1900
EEYQTKQAVL KASLPFVHQY GWTKKAIVAG AESLGMPSMV HGMFPRGGAE
1910 1920 1930 1940 1950
LVFYFYEESN KELESFLKQK VKELKEKDEK IKTGPFIHDA IETRLRMIIP
1960 1970 1980 1990 2000
YIDKWPQAMA IQTLPQNAVQ SWTNLSRVVD DIWFYAGDKS NDFNWYTKRG
2010 2020 2030 2040 2050
SLAAIYKSTE IYLIQDRSED YTDTWNFLEN RLEDVVSAGH LARNACIQVY
2060 2070
VFLKKLVICF SFKKPIQFYQ KVLKDFV
Length:2,077
Mass (Da):237,204
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF03AA4B1E8FCE26
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AFTI01009360 Genomic DNA No translation available.
AFTI01009361 Genomic DNA No translation available.
JH816961 Genomic DNA Translation: EKC37788.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EKC37788; EKC37788; CGI_10023552

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFTI01009360 Genomic DNA No translation available.
AFTI01009361 Genomic DNA No translation available.
JH816961 Genomic DNA Translation: EKC37788.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiK1QVV9

Genome annotation databases

EnsemblMetazoaiEKC37788; EKC37788; CGI_10023552

Phylogenomic databases

HOGENOMiCLU_232732_0_0_1

Enzyme and pathway databases

UniPathwayiUPA00232

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR016024, ARM-type_fold
IPR003959, ATPase_AAA_core
IPR013718, COQ9
IPR039041, Nav/unc-53
IPR027417, P-loop_NTPase
IPR012762, Ubiq_biosynth_COQ9
IPR013877, YAP-bd/ALF4/Glomulin
PANTHERiPTHR12784, PTHR12784, 1 hit
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF08511, COQ9, 1 hit
PF08568, Kinetochor_Ybp2, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR02396, diverge_rpsU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1QVV9_CRAGI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K1QVV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: February 10, 2021
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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