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Entry version 27 (31 Jul 2019)
Sequence version 1 (28 Nov 2012)
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Protein
Submitted name:

Rootletin

Gene

CGI_10027502

Organism
Crassostrea gigas (Pacific oyster) (Crassostrea angulata)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RootletinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CGI_10027502Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCrassostrea gigas (Pacific oyster) (Crassostrea angulata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005408 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni444 – 488DisorderedSequence analysisAdd BLAST45
Regioni610 – 631DisorderedSequence analysisAdd BLAST22
Regioni1401 – 1470DisorderedSequence analysisAdd BLAST70
Regioni2030 – 2080DisorderedSequence analysisAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili54 – 81Sequence analysisAdd BLAST28
Coiled coili89 – 109Sequence analysisAdd BLAST21
Coiled coili121 – 148Sequence analysisAdd BLAST28
Coiled coili170 – 197Sequence analysisAdd BLAST28
Coiled coili208 – 249Sequence analysisAdd BLAST42
Coiled coili329 – 363Sequence analysisAdd BLAST35
Coiled coili375 – 402Sequence analysisAdd BLAST28
Coiled coili515 – 570Sequence analysisAdd BLAST56
Coiled coili641 – 710Sequence analysisAdd BLAST70
Coiled coili732 – 752Sequence analysisAdd BLAST21
Coiled coili757 – 831Sequence analysisAdd BLAST75
Coiled coili874 – 969Sequence analysisAdd BLAST96
Coiled coili975 – 1016Sequence analysisAdd BLAST42
Coiled coili1018 – 1165Sequence analysisAdd BLAST148
Coiled coili1173 – 1193Sequence analysisAdd BLAST21
Coiled coili1201 – 1270Sequence analysisAdd BLAST70
Coiled coili1285 – 1386Sequence analysisAdd BLAST102
Coiled coili1489 – 1544Sequence analysisAdd BLAST56
Coiled coili1552 – 1607Sequence analysisAdd BLAST56
Coiled coili1615 – 1635Sequence analysisAdd BLAST21
Coiled coili1643 – 1712Sequence analysisAdd BLAST70
Coiled coili1720 – 1789Sequence analysisAdd BLAST70
Coiled coili1797 – 1873Sequence analysisAdd BLAST77
Coiled coili1881 – 1922Sequence analysisAdd BLAST42
Coiled coili1938 – 1980Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17PolyampholyteSequence analysisAdd BLAST17
Compositional biasi611 – 631PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1409 – 1444PolarSequence analysisAdd BLAST36

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K1QGF9

Identification of Orthologs from Complete Genome Data

More...
OMAi
HENNAQA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026733 Rootletin

The PANTHER Classification System

More...
PANTHERi
PTHR23159:SF34 PTHR23159:SF34, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K1QGF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEDFQIEKE GSDMESDVPE VPRPGFVRQK VDALEQSLRG QGGESLEAPS
60 70 80 90 100
KNLVQQNIEL RRKLEDEHAS YKRKLQAYQD GQQRQAQLVQ KLQAKLLQYK
110 120 130 140 150
KKCTDLEDAM RNKDFHYQFA NQKYKKKCED FEAENGDLKS RNDNLKLVLQ
160 170 180 190 200
YKHKCSDLED QIESKLQSTE ESYKKSLEAS ESRNMDLENT LIKLEEEQQR
210 220 230 240 250
SASLAHVNAM LREQLDQATA ANQSLTSDIH KLTQDWQAAR EELDIKEREW
260 270 280 290 300
RDEEQSFNEY FSAEHGRLLA LWRQVVAFRR SFGDLKTATE RDLSHVRNDV
310 320 330 340 350
TRASRSMHSA CLNLAANVRN SDTQSQVLLD RERSDRAAID NQLREKNREI
360 370 380 390 400
SELQSRYDAH SYELNAKVNE LTMMNEKLKI QLEERDKSIN TLQRQINNLE
410 420 430 440 450
TRLGERTSYD LPETDTARQI RGETEALHDA LRNIAEAVIN DADEFDGEEG
460 470 480 490 500
RRSISPSRAR SISPSARARS PMLRDRSKSP MARSRSPALA DATFSAVQAA
510 520 530 540 550
LNKRQLQLSE ARAKLRASQD HNAAIRKQMD DLDNERRRME LQILQLKEDV
560 570 580 590 600
DILRREREDT SRDRDRVKNA LSLTGTEKSQ LEKIRNELNE QIEMMQQENE
610 620 630 640 650
KLQAANTDLQ RQRDQLEDEK DDVTKDKERQ VKENDRCHRV IDQLEHKNST
660 670 680 690 700
IKEELVSTKE ALNRALLDKE VLEQQKSEVS DALSKAELQK AELELEINKA
710 720 730 740 750
KTEEATLKDA LLKMQAMNEG LGQDKVELNK IIMQMEAEQA SLTGEKDALE
760 770 780 790 800
MEKTGIKEEL TLELSEMTRQ QLEEEIQALN REKGDIQEQL SSVSRQKQAL
810 820 830 840 850
AEELLQARRE VERQNQNYVK VAKEKEMLTQ DKGELIVQVT ATERENRQQS
860 870 880 890 900
EVISSLRSEK DSLESALYES QQSESQLNVR KEQLEGENQE LILRKENLQS
910 920 930 940 950
EINRLIKEKE ADLEKFDRIK EDLQRRLTQF ERDMSLALTQ EKQAHEDDVE
960 970 980 990 1000
RLVKEREQQR HEFETERDEN VHQNAMEKEE LLNRFDRERE DLQEELANLQ
1010 1020 1030 1040 1050
RERDNQLLMA ENDKQQTMSL LEQEKSTLAE KNNTLTMELA NINVEYERLK
1060 1070 1080 1090 1100
REYLARQEQD KNNMNALNQE LRNLRGQFED TCMNHQKEIK DLTNQIRDLE
1110 1120 1130 1140 1150
RQREAALREV ADLKTQLKLV EEARDNVRRD LIDSNRKVRE EEEMLELMRK
1160 1170 1180 1190 1200
DMVELKRNLN DEVREKELFS KINDELRGTI KKNEGEKTEL NRDLCDHRQR
1210 1220 1230 1240 1250
CSILEEQKAN VQKEAADLRA SLREVEKARL EARRELQDLR RQVKMLDGER
1260 1270 1280 1290 1300
SKLGKEVNDL QARVAKDEEK EEEGRRHAFD LKQKVVETEA SREAVRKELA
1310 1320 1330 1340 1350
NLQRKMGELI DESRLKEKDY QMALEDSRRA ERKLEDQRRN LEINLENTNA
1360 1370 1380 1390 1400
EAAELKLRLS GSEGRVNALE AQLARIEGAK QDVEFKLSSI VSSLKRTIGF
1410 1420 1430 1440 1450
RQEMPRARSP VRSRSQSPRR SRPNSPSKGF ENTYATTTEG RGSPIPRTGS
1460 1470 1480 1490 1500
PERSGSPHRM SRGASPIRFD RTGEVNALDV DPEAVRMALR DFVQQLAGAE
1510 1520 1530 1540 1550
RERDDALANV RSMAIQLKEL EEEKDRTERR HQILQKSLGD VEEDKRGIDS
1560 1570 1580 1590 1600
RLASAQTALM LQEETIRRNE RERKVMTDKI NSLERSLAAA DTEKRQQEEK
1610 1620 1630 1640 1650
IAKLKANEMR NDENRKALKM ALDEAENRCT KLELGRRSLD GDLQRFKLVM
1660 1670 1680 1690 1700
NDKETENQVL QDRIEALNKQ IQGLESKSQS LQLTIDRLST NLQKTEEEES
1710 1720 1730 1740 1750
NQKERVQSLN LTLSDNQAII NELQDRISQL QKGLTSSEHD RRVLQERLDS
1760 1770 1780 1790 1800
TRQALNEAKK QNHGLLERVQ GLQNEVADSD VRRAELEGQL RQSHTMLVQR
1810 1820 1830 1840 1850
QEREQDLNQN IQKISSEKQL LHERVQELSR QMANLETEKS EMERSSARLE
1860 1870 1880 1890 1900
KDKSALKKTL DKVEREKLRT EEIASKSVME KGNLDRTLNR LEDDNTDLQK
1910 1920 1930 1940 1950
QVQQLQAQLA EAEQQHAQRL IDLTTRHRAE TEMETERLRS AQTQAERMLE
1960 1970 1980 1990 2000
TRERAHRAKV KGLEETVATL KDQLATEMRK RQQYISRSAR TGDEIRDIRS
2010 2020 2030 2040 2050
VLDNSMTNVM RDQSLDPLLL ETETRKLDDS MNFERSYPSQ SAPRRRLSPG
2060 2070 2080
RDYRRYGGLT STPNVRRSMS PLSLRKKLQK
Length:2,080
Mass (Da):242,469
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE399E6D18A5F791E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JH816729 Genomic DNA Translation: EKC35947.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EKC35947; EKC35947; CGI_10027502

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH816729 Genomic DNA Translation: EKC35947.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEKC35947; EKC35947; CGI_10027502

Phylogenomic databases

InParanoidiK1QGF9
OMAiHENNAQA

Family and domain databases

InterProiView protein in InterPro
IPR026733 Rootletin
PANTHERiPTHR23159:SF34 PTHR23159:SF34, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1QGF9_CRAGI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K1QGF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 31, 2019
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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