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Entry version 41 (16 Jan 2019)
Sequence version 1 (28 Nov 2012)
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Protein
Submitted name:

Multidrug resistance-associated protein 1

Gene

CGI_10025447

Organism
Crassostrea gigas (Pacific oyster) (Crassostrea angulata)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi413 – 420ATPPROSITE-ProRule annotation8
Nucleotide bindingi1067 – 1074ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Multidrug resistance-associated protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CGI_10025447Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCrassostrea gigas (Pacific oyster) (Crassostrea angulata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005408 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei60 – 87HelicalSequence analysisAdd BLAST28
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei191 – 217HelicalSequence analysisAdd BLAST27
Transmembranei288 – 309HelicalSequence analysisAdd BLAST22
Transmembranei321 – 345HelicalSequence analysisAdd BLAST25
Transmembranei703 – 720HelicalSequence analysisAdd BLAST18
Transmembranei755 – 788HelicalSequence analysisAdd BLAST34
Transmembranei831 – 849HelicalSequence analysisAdd BLAST19
Transmembranei855 – 876HelicalSequence analysisAdd BLAST22
Transmembranei941 – 962HelicalSequence analysisAdd BLAST22
Transmembranei968 – 988HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 346ABC transmembrane type-1InterPro annotationAdd BLAST284
Domaini378 – 603ABC transporterInterPro annotationAdd BLAST226
Domaini736 – 996ABC transmembrane type-1InterPro annotationAdd BLAST261
Domaini1033 – 1267ABC transporterInterPro annotationAdd BLAST235

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K1QF23

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWEIKES

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K1QF23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVRRKQNV YTKASETSEK TPLLGGKSGP VFTEGRVPDP PVPPSATPSL
60 70 80 90 100
STALVKTFGF MYLVSLAFKF ISDVLQFASP LLLGILIDYA DNRGEFSSWR
110 120 130 140 150
GYMPAIALFL ASCVQSVFYH QNYHVGMAVG MRIRSTLIAA IFRKALTLSP
160 170 180 190 200
SARKDSTLGE IVNLMSVDCQ RIQDTFTYSW SLMTCPLQLA LGIYLLWNVV
210 220 230 240 250
GASCIAGLVV LILMVPLNSY VVVKQRKLNV KVLRLKGQRT KLMTDILNGI
260 270 280 290 300
KVLKMYAWEP FFQEKVKNIR DQELKDLKKV AWLQGSTTFC WILAPYLVTL
310 320 330 340 350
ATFATYILVS PDNLLDAKKA FVALALFNIL RLPINLMSQT ISLLVQAVVS
360 370 380 390 400
IRRIQDFLVL TDLDPTNVHH STLSDYAIEV ENGSFSWDVD APTPILRDIN
410 420 430 440 450
LKIPEGMLIA VVGQVGSGKS SLVSALLGEM NKVEGTVNFR GSTAYVPQEA
460 470 480 490 500
WIQNATLMNN ILFGKPFIQK KYQKVIEACA LVPDLDMLPG RDHTEIGEKG
510 520 530 540 550
INISGGQKQR VSLARAVYSN SNVYLLDDPL SAVDSHVGKH IFDRVIGPKG
560 570 580 590 600
LLKNKTRVLV THGVHWLPMV DVVVVMVNGK ITETGSYDQL ITHDGPFAQF
610 620 630 640 650
LRQYFINEPD TEIENEHPDV SKIKTQMLEK VESVTSDALT SDTDGRRLSL
660 670 680 690 700
SVRRESKKLE LGKSSYPKPL EQPVTNQHQK LTSEEVSQEG QVKWSVFTEY
710 720 730 740 750
GKGVGVLTSV VVLVVFSLYH STSVFSNYWL TFWTEDQLLL NRTERNTTQY
760 770 780 790 800
YNRKVYYLTV YGVLGGIQGV LVFLYAIILS LGMVTAAGRL HHKMLRKILR
810 820 830 840 850
APMAFFDTTP VGRITNRFSA DIDIMDNTLP LTFRITLNSL FLALSTLIVC
860 870 880 890 900
TINTPYFAAV IVPMAILYYF IMKFYIPTAS QLKRMESVTR SPVFNHFSET
910 920 930 940 950
VTGASVIRAY KVQERFRDES ANRVDRNMEP YYINFSSSRW LGVRLEFLGN
960 970 980 990 1000
CLVLGATLFS IFSDLNGAIV GLSITYALQA TGILNLLVVN FSDLANNIVC
1010 1020 1030 1040 1050
VERIKEYYTD VSSEAEWTSP NPPPPDWPLS GQIAFNNYKT RYREGLDLVL
1060 1070 1080 1090 1100
KGVTLTINHG EKIGIVGRTG AGKSSMTLSL FRLIESAGGE ITIDGVRISD
1110 1120 1130 1140 1150
LGLHELRSKI TILPQDPVIF SGSLRLNLDP FNEYTDLQLW KALETAHLKS
1160 1170 1180 1190 1200
FVQSLTGQLQ YDCGEGGMSL SVGQRQLLCL ARTLLKKTKI LILDEATAAV
1210 1220 1230 1240 1250
DFQTDELIQE TIQKEFRDCT ILSIAHRLNT IIDYDRVMVL DSGHVTEFDS
1260 1270 1280 1290 1300
PDNLLARKDS LFYSMAKNAG LVVDIRGGKP VSPLVTSEPP RDPTSRPGSA
1310 1320 1330 1340 1350
SSQEGVPPPA SPVGPRPISP IGPPLTPISR MDSQDTLPRS SSSEFETNDQ
1360
SGSANGKKGE SEV
Length:1,363
Mass (Da):151,336
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9CA9BECA6F89120
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JH817025 Genomic DNA Translation: EKC27455.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EKC27455; EKC27455; CGI_10025447

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH817025 Genomic DNA Translation: EKC27455.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEKC27455; EKC27455; CGI_10025447

Phylogenomic databases

InParanoidiK1QF23
OMAiKWEIKES

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1QF23_CRAGI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K1QF23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: January 16, 2019
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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