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Entry version 35 (10 Feb 2021)
Sequence version 1 (28 Nov 2012)
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Protein
Submitted name:

EF-hand calcium-binding domain-containing protein 6

Gene

CGI_10014601

Organism
Crassostrea gigas (Pacific oyster) (Crassostrea angulata)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
EF-hand calcium-binding domain-containing protein 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CGI_10014601Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCrassostrea gigas (Pacific oyster) (Crassostrea angulata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaBivalviaAutobranchiaPteriomorphiaOstreidaOstreoideaOstreidaeCrassostrea
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005408 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
K1PYF0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 194EF-handInterPro annotationAdd BLAST32
Domaini282 – 301EF-handInterPro annotationAdd BLAST20
Domaini302 – 337EF-handInterPro annotationAdd BLAST36
Domaini396 – 431EF-handInterPro annotationAdd BLAST36
Domaini521 – 547EF-handInterPro annotationAdd BLAST27
Domaini549 – 584EF-handInterPro annotationAdd BLAST36
Domaini689 – 724EF-handInterPro annotationAdd BLAST36
Domaini766 – 801EF-handInterPro annotationAdd BLAST36
Domaini802 – 837EF-handInterPro annotationAdd BLAST36
Domaini881 – 916EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 60DisorderedSequence analysisAdd BLAST36
Regioni115 – 138DisorderedSequence analysisAdd BLAST24

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_308214_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K1PYF0

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLKDKFR

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR015070, EF_hand_DJBP
IPR002048, EF_hand_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08976, EF-hand_11, 1 hit
PF13499, EF-hand_7, 2 hits
PF13833, EF-hand_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K1PYF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQVGIPRPA SMGQKMGVSL PQIEHPLSRM GNPTNMDIRG VSRSGDRPLS
60 70 80 90 100
HPAGRPLANE NVYSGRKSVS AYGRDSRLGS RQMMQAPLPI DSIPEGVEVT
110 120 130 140 150
YGDPAKTRLP VFGSRADVGS RMDNGAPPSR MSSRLSQVST QARLEIDEIE
160 170 180 190 200
TMLKQRIKGS YYEIKKKFKD NDPEQKGNVS REAFYRILMT ILNRNVSQNV
210 220 230 240 250
FNRLMDRLGF KDKQIINYSE FFAYFHEAQA QNDYPRWMDP VQRMWPDKAI
260 270 280 290 300
MTSSQVHAQL KEKVRQKFLD IADLIPQMNP GGTGRILKPE FKQMLNKLMF
310 320 330 340 350
YMEDTEFEKL WKKYDPNNSG TVNGAQFLNA LGIQMENGGE ERQASPQLIT
360 370 380 390 400
GKDAKKVAKK VTLKEGPSSN RTPRKKEIER KQSLDIERWL KNKFREGCHQ
410 420 430 440 450
MQEAFEAKDP TNSGVVSFDV FLEVLAQYHL KLEKKLLAAF LSRCAVQARR
460 470 480 490 500
DGVPYRDFLH RFQDRSEVGM THNILTNTKH RLVRLVNDRP ASPSQVSTMS
510 520 530 540 550
GIEVQVMNMF QRDFLALLGT FKSIDKLGLN VISQEEFRAA IESRFNFHLQ
560 570 580 590 600
DDQFDAFVDR LPLDEDGNIK YADFMQQFDT KGKAKSLFEK QPGVDLSGPP
610 620 630 640 650
KVPSPILEVS PPEADEGVDR LVVDEPVFAD YAQVRRSPQE LFKVIKDLMN
660 670 680 690 700
RRFQDIERVF YELDEINSER LSQEMMFQLL KRFDIRPEVS RGEIRDLWKT
710 720 730 740 750
FITNTDKTLD YNEFVRHFGF SKKSASFPNA KMNPPKRGDA DFMIRSRKLN
760 770 780 790 800
CAADMLEDSL RSKVDYMWED LRKEFVEMDP YGTGFISREE FKDVLTELCV
810 820 830 840 850
HLSEFEINKL SDKFDLKRDG RVSYIEFLKP FALRKQIWRH GNNMLSLLAH
860 870 880 890 900
PQPELPIHDI VEPPQKGLHG ITSKLRQKLA GDWKNLRRAF RKLDTRNEGY
910 920 930 940 950
LSVPEFRSVL KLANVILDED EVYHVLTQFD HNMSGKIPYE KFIEETFKPP

TRQSVRKI
Length:958
Mass (Da):110,683
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2CF4BE67D45130B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AFTI01001287 Genomic DNA No translation available.
JH815881 Genomic DNA Translation: EKC29292.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EKC29292; EKC29292; CGI_10014601

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFTI01001287 Genomic DNA No translation available.
JH815881 Genomic DNA Translation: EKC29292.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiK1PYF0

Genome annotation databases

EnsemblMetazoaiEKC29292; EKC29292; CGI_10014601

Phylogenomic databases

HOGENOMiCLU_308214_0_0_1
InParanoidiK1PYF0
OMAiWLKDKFR

Family and domain databases

CDDicd00051, EFh, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR015070, EF_hand_DJBP
IPR002048, EF_hand_dom
PfamiView protein in Pfam
PF08976, EF-hand_11, 1 hit
PF13499, EF-hand_7, 2 hits
PF13833, EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 8 hits
SUPFAMiSSF47473, SSF47473, 5 hits
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1PYF0_CRAGI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K1PYF0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: February 10, 2021
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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