UniProtKB - K0ZJ08 (K0ZJ08_9ACTO)
Protein
Chromosomal replication initiator protein DnaA
Gene
dnaA
Organism
Schaalia turicensis ACS-279-V-Col4
Status
Functioni
Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 228 – 235 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA replication origin binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA replication initiation Source: UniProtKB-UniRule
- regulation of DNA replication Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | DNA replicationUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Chromosomal replication initiator protein DnaAUniRule annotationARBA annotation |
Gene namesi | Name:dnaAUniRule annotation ORF Names:HMPREF9241_00388Imported |
Organismi | Schaalia turicensis ACS-279-V-Col4Imported |
Taxonomic identifieri | 883077 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Actinomycetales › Actinomycetaceae › Schaalia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotationARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 220 – 357 | AAAInterPro annotationAdd BLAST | 138 | |
Domaini | 437 – 505 | Bac_DnaA_CInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 133 | DisorderedSequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 87 – 102 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 103 – 133 | PolarSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0593, Bacteria |
HOGENOMi | CLU_026910_2_0_11 |
OrthoDBi | 219876at2 |
Family and domain databases
CDDi | cd06571, Bac_DnaA_C, 1 hit |
Gene3Di | 1.10.1750.10, 1 hit 3.30.300.180, 1 hit |
HAMAPi | MF_00377, DnaA_bact, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR001957, Chromosome_initiator_DnaA IPR020591, Chromosome_initiator_DnaA-like IPR018312, Chromosome_initiator_DnaA_CS IPR013317, DnaA IPR013159, DnaA_C IPR038454, DnaA_N_sf IPR027417, P-loop_NTPase IPR010921, Trp_repressor/repl_initiator |
PANTHERi | PTHR30050:SF2, PTHR30050:SF2, 1 hit |
Pfami | View protein in Pfam PF00308, Bac_DnaA, 1 hit PF08299, Bac_DnaA_C, 1 hit |
PRINTSi | PR00051, DNAA |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00760, Bac_DnaA_C, 1 hit |
SUPFAMi | SSF48295, SSF48295, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00362, DnaA, 1 hit |
PROSITEi | View protein in PROSITE PS01008, DNAA, 1 hit |
i Sequence
Sequence statusi: Complete.
K0ZJ08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METPSLNAAW TQALELLAQT GLGPAGMGFL QSTRPLGNIE GTILLSVPND
60 70 80 90 100
FTKNWIERSS SSVTDALSQT FGKRTRIAIT VDPDMELPET ADEKEHQAKN
110 120 130 140 150
VEVASSTEDN QPTTNEVPSA GHHQTGDTPT YAQSFSYPSA EERLRQLDGV
160 170 180 190 200
EAINDFPDSS FEEHDPKRFS YVAPQSTDRA LDTSSTRLNP KHTFDTFVIG
210 220 230 240 250
PSNRFAHAAA VAVSESPGTD FNPLFIYGES GLGKTHLLQA IGHYTLSLYP
260 270 280 290 300
NQKVRYVSSE EFTNEFINAI RVNNPNNSAV EEFHRRYREL DLLLIDDIQF
310 320 330 340 350
LSKKEQTMEG FFHTFNALYQ ANKQIVITSD VQPKHLEGIE ERLRSRFGSG
360 370 380 390 400
LLVDVQPPDL ETRIAILQKK TADENLDIDP EIFTYIAERI SSNIRELEGA
410 420 430 440 450
ILRVVAYANL YHEKIDLALA EMTLKDYISD PDDTEITIPL IMGQCAKYFN
460 470 480 490 500
VTIDQLCSTD RSRAIVEARQ IAMYLCRELT ELSLPKIGQS FDRDHSTVMH
510 520 530
ANKKILEQMK QRREVYNDVT ELTNRIKKVA RGGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGWQ01000003 Genomic DNA Translation: EJZ87760.1 |
RefSeqi | WP_006680594.1, NZ_JH815208.1 |
Genome annotation databases
EnsemblBacteriai | EJZ87760; EJZ87760; HMPREF9241_00388 |
PATRICi | fig|883077.3.peg.380 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGWQ01000003 Genomic DNA Translation: EJZ87760.1 |
RefSeqi | WP_006680594.1, NZ_JH815208.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 883077.HMPREF9241_00388 |
Genome annotation databases
EnsemblBacteriai | EJZ87760; EJZ87760; HMPREF9241_00388 |
PATRICi | fig|883077.3.peg.380 |
Phylogenomic databases
eggNOGi | COG0593, Bacteria |
HOGENOMi | CLU_026910_2_0_11 |
OrthoDBi | 219876at2 |
Family and domain databases
CDDi | cd06571, Bac_DnaA_C, 1 hit |
Gene3Di | 1.10.1750.10, 1 hit 3.30.300.180, 1 hit |
HAMAPi | MF_00377, DnaA_bact, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR001957, Chromosome_initiator_DnaA IPR020591, Chromosome_initiator_DnaA-like IPR018312, Chromosome_initiator_DnaA_CS IPR013317, DnaA IPR013159, DnaA_C IPR038454, DnaA_N_sf IPR027417, P-loop_NTPase IPR010921, Trp_repressor/repl_initiator |
PANTHERi | PTHR30050:SF2, PTHR30050:SF2, 1 hit |
Pfami | View protein in Pfam PF00308, Bac_DnaA, 1 hit PF08299, Bac_DnaA_C, 1 hit |
PRINTSi | PR00051, DNAA |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00760, Bac_DnaA_C, 1 hit |
SUPFAMi | SSF48295, SSF48295, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00362, DnaA, 1 hit |
PROSITEi | View protein in PROSITE PS01008, DNAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K0ZJ08_9ACTO | |
Accessioni | K0ZJ08Primary (citable) accession number: K0ZJ08 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 28, 2012 |
Last sequence update: | November 28, 2012 | |
Last modified: | April 7, 2021 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |