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Protein

4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

MFORT_16921

Organism
Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.UniRule annotationSAAS annotation
Oxaloacetate = pyruvate + CO2.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-4-methyl-2-oxoglutarate aldolaseUniRule annotationSAAS annotation (EC:4.1.1.3UniRule annotation, EC:4.1.3.17UniRule annotationSAAS annotation)
Short name:
HMG aldolaseUniRule annotation
Alternative name(s):
Oxaloacetate decarboxylaseUniRule annotation
Gene namesi
ORF Names:MFORT_16921Imported
OrganismiMycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841Imported
Taxonomic identifieri1214102 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000006043 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H03SM

Family and domain databases

CDDicd16841 RraA_family, 1 hit
InterProiView protein in InterPro
IPR010203 RraA
IPR005493 RraA/RraA-like
IPR036704 RraA/RraA-like_sf
PfamiView protein in Pfam
PF03737 RraA-like, 1 hit
SUPFAMiSSF89562 SSF89562, 1 hit
TIGRFAMsiTIGR01935 NOT-MenG, 1 hit

Sequencei

Sequence statusi: Complete.

K0VNN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEPRATAD LVDEIYPDVR SCDLQLQNYG GRTMFAGPIT TVRCFQDNAL
60 70 80 90 100
LKSILSTPGD GGVLVVDGNG SLHTALVGDI IAGLAAEHGW SGVIVHGAVR
110 120 130 140 150
DAAALRTIDV GIKALGTNPR KGTKTGEGER DVEVSFGGVT FVPGEIAYAD
160
EDGIVVVGDD R
Length:161
Mass (Da):16,751
Last modified:November 28, 2012 - v1
Checksum:i0A54E12380299DCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ALQB01000068 Genomic DNA Translation: EJZ12814.1
RefSeqiWP_003883968.1, NZ_JH814746.1

Genome annotation databases

EnsemblBacteriaiEJZ12814; EJZ12814; MFORT_16921
PATRICifig|1214102.3.peg.3359

Similar proteinsi

Entry informationi

Entry nameiK0VNN3_MYCFO
AccessioniPrimary (citable) accession number: K0VNN3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 18, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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