Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate--CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Nitrososphaera gargensis (strain Ga9.2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha (sucD)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60Coenzyme AUniRule annotation1
Binding sitei176Substrate; shared with subunit betaUniRule annotation1
Active sitei265Tele-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandNucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00223; UER00999

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
Alternative name(s):
Succinyl-CoA synthetase subunit alphaUniRule annotation
Short name:
SCS-alphaUniRule annotation
Gene namesi
Name:sucDUniRule annotationImported
Ordered Locus Names:Ngar_c15470Imported
OrganismiNitrososphaera gargensis (strain Ga9.2)Imported
Taxonomic identifieri1237085 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrososphaeriaNitrososphaeralesNitrososphaeraceaeNitrososphaera
Proteomesi
  • UP000008037 Componenti: Chromosome

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 117CoA_bindingInterPro annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Coenzyme A bindingUniRule annotation4

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Phylogenomic databases

KOiK01902
OMAiIIFVPPA
OrthoDBiPOG093Z0657

Family and domain databases

Gene3Di3.40.50.261, 1 hit
HAMAPiMF_01988 Succ_CoA_alpha, 1 hit
InterProiView protein in InterPro
IPR017440 Cit_synth/succinyl-CoA_lig_AS
IPR003781 CoA-bd
IPR005810 CoA_lig_alpha
IPR005811 CoA_ligase
IPR036291 NAD(P)-bd_dom_sf
IPR016102 Succinyl-CoA_synth-like
PfamiView protein in Pfam
PF02629 CoA_binding, 1 hit
PF00549 Ligase_CoA, 1 hit
PIRSFiPIRSF001553 SucCS_alpha, 1 hit
SMARTiView protein in SMART
SM00881 CoA_binding, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF52210 SSF52210, 1 hit
PROSITEiView protein in PROSITE
PS00399 SUCCINYL_COA_LIG_2, 1 hit

Sequencei

Sequence statusi: Complete.

K0IAX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVEKTFNI FDILVGNKGD KDFGKKPVVI QGITGSYGST HTRLMKAYGT
60 70 80 90 100
NIAAGVTPGK GGQNFEGTPV YDTMADAVKA TGAQISGIFV PAPFFLKAAI
110 120 130 140 150
EALDSGIKLL VAIPEHVPIR DSIKVLEHAR KKGARMVGPN TPGVIVPEVM
160 170 180 190 200
KVGIMPAQPF KAGSTVVFSR SGTLMYEVSY NLTNKGYGQR LCLGIGGDPI
210 220 230 240 250
NGTNLIEAFD LIRDRSDVDS VVVVGEIGGD AEEQLAEYII RTSFDKPVIA
260 270 280 290 300
YIAGRAAPKE KRMGHAGAIV YGNYGSAESK VANYAKAGVP VAKRPAEVPE

LLAKKLRK
Length:308
Mass (Da):32,697
Last modified:November 28, 2012 - v1
Checksum:i42B5DF6B4494854C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002408 Genomic DNA Translation: AFU58481.1

Genome annotation databases

EnsemblBacteriaiAFU58481; AFU58481; Ngar_c15470
KEGGinga:Ngar_c15470
PATRICifig|1237085.11.peg.1514

Similar proteinsi

Entry informationi

Entry nameiK0IAX0_NITGG
AccessioniPrimary (citable) accession number: K0IAX0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 25, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health