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Entry version 38 (02 Jun 2021)
Sequence version 1 (28 Nov 2012)
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Protein

ABC transporter ecdL

Gene

ecdL

Organism
Aspergillus rugulosus (Emericella rugulosa)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ABC transporter; part of the gene cluster that mediates the biosynthesis of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent (PubMed:22998630).

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi641 – 648ATPPROSITE-ProRule annotation8
Nucleotide bindingi1264 – 1271ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.41, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter ecdL1 Publication
Alternative name(s):
Echinocandin B biosynthetic cluster protein L1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ecdL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus rugulosus (Emericella rugulosa)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri41736 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei365 – 382HelicalSequence analysisAdd BLAST18
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei469 – 489HelicalSequence analysisAdd BLAST21
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Transmembranei885 – 905HelicalSequence analysisAdd BLAST21
Transmembranei955 – 975HelicalSequence analysisAdd BLAST21
Transmembranei1028 – 1048HelicalSequence analysisAdd BLAST21
Transmembranei1052 – 1072HelicalSequence analysisAdd BLAST21
Transmembranei1135 – 1155HelicalSequence analysisAdd BLAST21
Transmembranei1165 – 1185HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Due to their effectiveness as antifungal agents, echinocandin derivatives can be used for the treatment of human invasive candidiasis (PubMed:22998630).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004438501 – 1479ABC transporter ecdLAdd BLAST1479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi183N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi234N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi345N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi427N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi611N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi628N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi793N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi797N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1161N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1187N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
K0E4D9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini258 – 535ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST278
Domaini607 – 835ABC transporter 1PROSITE-ProRule annotationAdd BLAST229
Domaini932 – 1193ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST262
Domaini1230 – 1461ABC transporter 2PROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1460 – 1479DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1464 – 1479Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 1 hit
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K0E4D9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDSPWPQCD IRVQDTFGPQ VSGCYEDFDF TLLFEESILY LPPLLIAASV
60 70 80 90 100
ALLRIWQLRS TENLLKRSGL LSILKPTSTT RLSNAAIAIG FVASPIFAWL
110 120 130 140 150
SFWEHARSLR PSTILNVYLL GTIPMDAARA RTLFRMPGNS AIASIFATIV
160 170 180 190 200
VCKVVLLVVE AMEKQRLLLD RGWAPEETAG ILNRSFLWWF NPLLLSGYKQ
210 220 230 240 250
ALTVDKLLAV DEDIGVEKSK DEIRRRWAQA VKQNASSLQD VLLAVYRTEL
260 270 280 290 300
WGGFLPRLCL IGVNYAQPFL VNRVVTFLGQ PDTSTSRGVA SGLIAAYAIV
310 320 330 340 350
YMGIAVATAA FHHRSYRMVM MVRGGLILLI YDHTLTLNAL SPSKNDSYTL
360 370 380 390 400
ITADIERIVS GLRSLHETWA SLIEIALSLW LLETKIRVSA VAAAMVVLVC
410 420 430 440 450
LLVSGALSGL LGVHQNLWLE AMQKRLNATL ATIGSIKGIK ATGRTNTLYE
460 470 480 490 500
TILQLRRTEI QKSLKFRELL VALVTLSYLS TTMAPTFAFG TYSILAKIRN
510 520 530 540 550
MTPLLAAPAF SSLTIMTLLG QAVSGFVESL MGLRQAMASL ERIRQYLVGK
560 570 580 590 600
EAPEPSPNKP GVASTEGLVA WSASLDEPGL DPRVEMRRMS SLQHRFYNLG
610 620 630 640 650
ELQDGLIVLQ NHTASWEKAS KPVLTDINVT ITRGSFVIVI GPIGSGKSTL
660 670 680 690 700
LHSILGEVPH TTGIRTIQEV DTAFCAQTPW LTNTNVRDNI LGASHFDPAW
710 720 730 740 750
YNAVVKACAL HRDFAQLPHG DRSMIGSKGI LLSGGQKGRL ALARALYARK
760 770 780 790 800
ALLVLDDVFA GLDPKTGQEV FTSLFGARGL LRQGKTTTVL ATNSTQNLSM
810 820 830 840 850
ADYIMVLGSE GRLIEQGTPT ELLNSGSSLR LEELVKTREG KSKAEPERER
860 870 880 890 900
PEYARALRNS VLGATPVAAR RRFSDMAIYK LYIRTIGWGS WWIFIVLCSG
910 920 930 940 950
FVVALTLSRE NTLALPSACA GVDLLTACLE EIWLKFWTEA NARNPHDRLG
960 970 980 990 1000
YYLSLFAVWS ALAITFFLGA CLHLMLRMVP KAAKIFHGSL LQTVMRAPLV
1010 1020 1030 1040 1050
FFSKTDSGEI SNHFSQDLEL IDMELPRALI GAVIALILCI SAMAVIVYSS
1060 1070 1080 1090 1100
NYLAATIPGL LGLLYLVQMF YLRTSQQLRV LELETRAPLL SHYMETIQGL
1110 1120 1130 1140 1150
VSLRAFGWSK HFKDRHHGHL KVAQQSAYLL FCAQIWLTLT LDIIVAFLAI
1160 1170 1180 1190 1200
ILVSIAVTVK NSSAASIGLA LVNLIAFGAN MKGLVYNWTA LENAMGAIAR
1210 1220 1230 1240 1250
VRDFTTETPC EIQVGESHSP SPGWPQRGLI KFKSVTASYD FTSHPVLNDV
1260 1270 1280 1290 1300
TFTVQPGEKL AICGRTGCGK SSLVSSLLRL LEVRNGAIEV DGIDISTLSR
1310 1320 1330 1340 1350
EDVRMSLNVL PQEPFFYHGT IRQNLDPNCL SSDEEILETL ALLGLREVIS
1360 1370 1380 1390 1400
KKGGLDVAMD DGFLSHGQQQ LLCLARAILK KSRILILDEV TSSVDQETET
1410 1420 1430 1440 1450
LITRVLRDRL QDQTVISIAH RLNTIMDYDK VIILDKGCIV EQGNPQVLAL
1460 1470
QRSIFASLLR SGDEEPGNGH KHESEGEEE
Length:1,479
Mass (Da):162,954
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45AF7AC776A9452F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX421684 Genomic DNA Translation: AFT91383.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX421684 Genomic DNA Translation: AFT91383.1

3D structure databases

SMRiK0E4D9
ModBaseiSearch...

Protein family/group databases

TCDBi3.A.1.208.41, the atp-binding cassette (abc) superfamily

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00664, ABC_membrane, 1 hit
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECDL_ASPRU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K0E4D9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 25, 2018
Last sequence update: November 28, 2012
Last modified: June 2, 2021
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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