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Entry version 71 (02 Jun 2021)
Sequence version 1 (28 Nov 2012)
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Protein

2'-O-methyltransferase

Gene

orf1ab

Organism
Human betacoronavirus 2c EMC/2012
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).

ARBA annotation

Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.

ARBA annotation

Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

ARBA annotation

Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

ARBA annotation

May participate in viral replication by acting as a ssRNA-binding protein.

ARBA annotation

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.

ARBA annotation

Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.

ARBA annotation

Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.

ARBA annotation

Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.

ARBA annotation

Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.

ARBA annotation

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.

ARBA annotation

Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.

ARBA annotation

Responsible for replication and transcription of the viral RNA genome.

ARBA annotation

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.

ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.ARBA annotation EC:3.4.22.69
  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ARBA annotation EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1672ZincCombined sources1
Metal bindingi1675ZincCombined sources1
Metal bindingi1707ZincCombined sources1
Metal bindingi1709ZincCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseARBA annotation, ExonucleaseARBA annotation, HelicaseARBA annotation, Hydrolase, MethyltransferaseARBA annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase
Biological processActivation of host autophagy by virusARBA annotation, Decay of host mRNAs by virusARBA annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusARBA annotation, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virusARBA annotation, Inhibition of host NF-kappa-B by virusARBA annotation, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion, Viral RNA replicationARBA annotation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C30.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2'-O-methyltransferaseARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.4.19.12ARBA annotation, EC:3.4.22.69ARBA annotation, EC:3.6.4.12ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
3C-like proteinaseARBA annotation
Growth factor-like peptideARBA annotation
Guanine-N7 methyltransferaseARBA annotation
HelicaseARBA annotation
Host translation inhibitor nsp1ARBA annotation
Leader proteinARBA annotation
NendoUARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
ORF1ab polyproteinARBA annotation
Papain-like proteinaseARBA annotation
RNA-directed RNA polymeraseARBA annotation
Replicase polyprotein 1abARBA annotation
Uridylate-specific endoribonucleaseARBA annotation
nsp12ARBA annotation
nsp13ARBA annotation
nsp14ARBA annotation
nsp15ARBA annotation
nsp16ARBA annotation
nsp5ARBA annotation
p65 homologARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:orf1abImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman betacoronavirus 2c EMC/2012Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1235996 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeBetacoronavirusMerbecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000112279 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2175 – 2195HelicalSequence analysisAdd BLAST21
Transmembranei2307 – 2325HelicalSequence analysisAdd BLAST19
Transmembranei2337 – 2362HelicalSequence analysisAdd BLAST26
Transmembranei2756 – 2777HelicalSequence analysisAdd BLAST22
Transmembranei3024 – 3049HelicalSequence analysisAdd BLAST26
Transmembranei3061 – 3092HelicalSequence analysisAdd BLAST32
Transmembranei3112 – 3138HelicalSequence analysisAdd BLAST27
Transmembranei3564 – 3582HelicalSequence analysisAdd BLAST19
Transmembranei3594 – 3613HelicalSequence analysisAdd BLAST20
Transmembranei3620 – 3638HelicalSequence analysisAdd BLAST19
Transmembranei3669 – 3687HelicalSequence analysisAdd BLAST19
Transmembranei3694 – 3710HelicalSequence analysisAdd BLAST17
Transmembranei3730 – 3752HelicalSequence analysisAdd BLAST23
Transmembranei3764 – 3786HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi5389InterchainCombined sources

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.

ARBA annotation

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5789, MERS-CoV NSP10-NSP16 2'-O-methyltransferase complex

Protein interaction database and analysis system

More...
IntActi
K0BWD0, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
K0BWD0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1110 – 1276MacroInterPro annotationAdd BLAST167
Domaini1552 – 1823Peptidase C16InterPro annotationAdd BLAST272
Domaini3248 – 3553Peptidase C30InterPro annotationAdd BLAST306
Domaini4990 – 5152RdRp catalyticInterPro annotationAdd BLAST163
Domaini5311 – 5394CV ZBDInterPro annotationAdd BLAST84
Domaini5567 – 5923(+)RNA virus helicase C-terminalInterPro annotationAdd BLAST357

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd21409, 1B_cv_Nsp13-like, 1 hit
cd21560, betaCoV-Nsp6, 1 hit
cd21659, betaCoV_Nsp14, 1 hit
cd21666, betaCoV_Nsp5_Mpro, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21517, cv_beta_Nsp2_MERS-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21165, M_cv-Nsp15-like, 1 hit
cd21563, Macro_cv_SUD-M_Nsp3-like, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21592, MERS-CoV-like_RdRp, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit
cd21523, SUD_C_MERS-CoV_Nsp3, 1 hit
cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.50.11020, 1 hit
3.40.50.11580, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR042570, NAR_sf
IPR043609, NendoU_nidovirus
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR044315, NSP14_betaCoV
IPR009466, NSP14_CoV
IPR044330, NSP15_alpha_betaCoV_N
IPR044327, NSP15_M_betaCoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR021590, NSP1_bCoV
IPR044388, NSP2_MERS-like
IPR043615, NSP2_N_CoV
IPR024375, NSP3_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR044382, NSP3_SUD_C_MERS-CoV
IPR044357, NSP3_Ubl1_dom_CoV
IPR044353, Nsp3_Ubl2_dom_CoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044367, NSP6_betaCoV
IPR043610, NSP6_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR044350, RdRp_MERS-CoV-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13087, AAA_12, 1 hit
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K0BWD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFVAGVTAQ GARGTYRAAL NSEKHQDHVS LTVPLCGSGN LVEKLSPWFM
60 70 80 90 100
DGENAYEVVK AMLLKKEPLL YVPIRLAGHT RHLPGPRVYL VERLIACENP
110 120 130 140 150
FMVNQLAYSS SANGSLVGTT LQGKPIGMFF PYDIELVTGK QNILLRKYGR
160 170 180 190 200
GGYHYTPFHY ERDNTSCPEW MDDFEADPKG KYAQNLLKKL IGGDVTPVDQ
210 220 230 240 250
YMCGVDGKPI SAYAFLMAKD GITKLADVEA DVAARADDEG FITLKNNLYR
260 270 280 290 300
LVWHVERKDV PYPKQSIFTI NSVVQKDGVE NTPPHYFTLG CKILTLTPRN
310 320 330 340 350
KWSGVSDLSL KQKLLYTFYG KESLENPTYI YHSAFIECGS CGNDSWLTGN
360 370 380 390 400
AIQGFACGCG ASYTANDVEV QSSGMIKPNA LLCATCPFAK GDSCSSNCKH
410 420 430 440 450
SVAQLVSYLS ERCNVIADSK SFTLIFGGVA YAYFGCEEGT MYFVPRAKSV
460 470 480 490 500
VSRIGDSIFT GCTGSWNKVT QIANMFLEQT QHSLNFVGEF VVNDVVLAIL
510 520 530 540 550
SGTTTNVDKI RQLLKGVTLD KLRDYLADYD VAVTAGPFMD NAINVGGTGL
560 570 580 590 600
QYAAITAPYV VLTGLGESFK KVATIPYKVC NSVKDTLAYY AHSVLYRVFP
610 620 630 640 650
YDMDSGVSSF SELLFDCVDL SVASTYFLVR ILQDKTGDFM STIITSCQTA
660 670 680 690 700
VSKLLDTCFE ATEATFNFLL DLAGLFRIFL RNAYVYTSQG FVVVNGKVST
710 720 730 740 750
LVKQVLDLLN KGMQLLHTKV SWAGSKIIAV IYSGRESLIF PSGTYYCVTT
760 770 780 790 800
KAKSVQQDLD VILPGEFSKK QLGLLQPTDN STTVSVTVSS NMVETVVGQL
810 820 830 840 850
EQTNMHSPDV IVGDYVIISE KLFVRSKEED GFAFYPACTN GHAVPTLFRL
860 870 880 890 900
KGGAPVKKVA FGGDQVHEVA AVRSVTVEYN IHAVLDTLLA SSSLRTFVVD
910 920 930 940 950
KSLSIEEFAD VVKEQVSDLL VKLLRGMPIP DFDLDDFIDA PCYCFNAEGD
960 970 980 990 1000
ASWSSTMIFS LHPVECDEEC SEVEASDLEE GESECISETS TEQVDVSHET
1010 1020 1030 1040 1050
SDDEWAAAVD EAFPLDEAED VTESVQEEAQ PVEVPVEDIA QVVIADTLQE
1060 1070 1080 1090 1100
TPVVPDTVEV PPQVVKLPSA PQTIQPEVKE VAPVYEADTE QTQNVTVKPK
1110 1120 1130 1140 1150
RLRKKRNVDP LSNFEHKVIT ECVTIVLGDA IQVAKCYGES VLVNAANTHL
1160 1170 1180 1190 1200
KHGGGIAGAI NAASKGAVQK ESDEYILAKG PLQVGDSVLL QGHSLAKNIL
1210 1220 1230 1240 1250
HVVGPDARAK QDVSLLSKCY KAMNAYPLVV TPLVSAGIFG VKPAVSFDYL
1260 1270 1280 1290 1300
IREAKTRVLV VVNSQDVYKS LTIVDIPQSL TFSYDGLRGA IRKAKDYGFT
1310 1320 1330 1340 1350
VFVCTDNSAN TKVLRNKGVD YTKKFLTVDG VQYYCYTSKD TLDDILQQAN
1360 1370 1380 1390 1400
KSVGIISMPL GYVSHGLDLM QAGSVVRRVN VPYVCLLANK EQEAILMSED
1410 1420 1430 1440 1450
VKLNPSEDFI KHVRTNGGYN SWHLVEGELL VQDLRLNKLL HWSDQTICYK
1460 1470 1480 1490 1500
DSVFYVVKNS TAFPFETLSA CRAYLDSRTT QQLTIEVLVT VDGVNFRTVV
1510 1520 1530 1540 1550
LNNKNTYRSQ LGCVFFNGAD ISDTIPDEKQ NGHSLYLADN LTADETKALK
1560 1570 1580 1590 1600
ELYGPVDPTF LHRFYSLKAA VHGWKMVVCD KVRSLKLSDN NCYLNAVIMT
1610 1620 1630 1640 1650
LDLLKDIKFV IPALQHAFMK HKGGDSTDFI ALIMAYGNCT FGAPDDASRL
1660 1670 1680 1690 1700
LHTVLAKAEL CCSARMVWRE WCNVCGIKDV VLQGLKACCY VGVQTVEDLR
1710 1720 1730 1740 1750
ARMTYVCQCG GERHRQLVEH TTPWLLLSGT PNEKLVTTST APDFVAFNVF
1760 1770 1780 1790 1800
QGIETAVGHY VHARLKGGLI LKFDSGTVSK TSDWKCKVTD VLFPGQKYSS
1810 1820 1830 1840 1850
DCNVVRYSLD GNFRTEVDPD LSAFYVKDGK YFTSEPPVTY SPATILAGSV
1860 1870 1880 1890 1900
YTNSCLVSSD GQPGGDAISL SFNNLLGFDS SKPVTKKYTY SFLPKEDGDV
1910 1920 1930 1940 1950
LLAEFDTYDP IYKNGAMYKG KPILWVNKAS YDTNLNKFNR ASLRQIFDVA
1960 1970 1980 1990 2000
PIELENKFTP LSVESTPVEP PTVDVVALQQ EMTIVKCKGL NKPFVKDNVS
2010 2020 2030 2040 2050
FVADDSGTPV VEYLSKEDLH TLYVDPKYQV IVLKDNVLSS MLRLHTVESG
2060 2070 2080 2090 2100
DINVVAASGS LTRKVKLLFR ASFYFKEFAT RTFTATTAVG SCIKSVVRHL
2110 2120 2130 2140 2150
GVTKGILTGC FSFAKMLFML PLAYFSDSKL GTTEVKVSAL KTAGVVTGNV
2160 2170 2180 2190 2200
VKQCCTAAVD LSMDKLRRVD WKSTLRLLLM LCTTMVLLSS VYHLYVFNQV
2210 2220 2230 2240 2250
LSSDVMFEDA QGLKKFYKEV RAYLGISSAC DGLASAYRAN SFDVPTFCAN
2260 2270 2280 2290 2300
RSAMCNWCLI SQDSITHYPA LKMVQTHLSH YVLNIDWLWF AFETGLAYML
2310 2320 2330 2340 2350
YTSAFNWLLL AGTLHYFFAQ TSIFVDWRSY NYAVSSAFWL FTHIPMAGLV
2360 2370 2380 2390 2400
RMYNLLACLW LLRKFYQHVI NGCKDTACLL CYKRNRLTRV EASTVVCGGK
2410 2420 2430 2440 2450
RTFYITANGG ISFCRRHNWN CVDCDTAGVG NTFICEEVAN DLTTALRRPI
2460 2470 2480 2490 2500
NATDRSHYYV DSVTVKETVV QFNYRRDGQP FYERFPLCAF TNLDKLKFKE
2510 2520 2530 2540 2550
VCKTTTGIPE YNFIIYDSSD RGQESLARSA CVYYSQVLCK SILLVDSSLV
2560 2570 2580 2590 2600
TSVGDSSEIA TKMFDSFVNS FVSLYNVTRD KLEKLISTAR DGVRRGDNFH
2610 2620 2630 2640 2650
SVLTTFIDAA RGPAGVESDV ETNEIVDSVQ YAHKHDIQIT NESYNNYVPS
2660 2670 2680 2690 2700
YVKPDSVSTS DLGSLIDCNA ASVNQIVLRN SNGACIWNAA AYMKLSDALK
2710 2720 2730 2740 2750
RQIRIACRKC NLAFRLTTSK LRANDNILSV RFTANKIVGG APTWFNALRD
2760 2770 2780 2790 2800
FTLKGYVLAT IIVFLCAVLM YLCLPTFSMA PVEFYEDRIL DFKVLDNGII
2810 2820 2830 2840 2850
RDVNPDDKCF ANKHRSFTQW YHEHVGGVYD NSITCPLTVA VIAGVAGARI
2860 2870 2880 2890 2900
PDVPTTLAWV NNQIIFFVSR VFANTGSVCY TPIDEIPYKS FSDSGCILPS
2910 2920 2930 2940 2950
ECTMFRDAEG RMTPYCHDPT VLPGAFAYSQ MRPHVRYDLY DGNMFIKFPE
2960 2970 2980 2990 3000
VVFESTLRIT RTLSTQYCRF GSCEYAQEGV CITTNGSWAI FNDHHLNRPG
3010 3020 3030 3040 3050
VYCGSDFIDI VRRLAVSLFQ PITYFQLTTS LVLGIGLCAF LTLLFYYINK
3060 3070 3080 3090 3100
VKRAFADYTQ CAVIAVVAAV LNSLCICFVT SIPLCIVPYT ALYYYATFYF
3110 3120 3130 3140 3150
TNEPAFIMHV SWYIMFGPIV PIWMTCVYTV AMCFRHFFWV LAYFSKKHVE
3160 3170 3180 3190 3200
VFTDGKLNCS FQDAASNIFV INKDTYAALR NSLTNDAYSR FLGLFNKYKY
3210 3220 3230 3240 3250
FSGAMETAAY REAAACHLAK ALQTYSETGS DLLYQPPNCS ITSGVLQSGL
3260 3270 3280 3290 3300
VKMSHPSGDV EACMVQVTCG SMTLNGLWLD NTVWCPRHVM CPADQLSDPN
3310 3320 3330 3340 3350
YDALLISMTN HSFSVQKHIG APANLRVVGH AMQGTLLKLT VDVANPSTPA
3360 3370 3380 3390 3400
YTFTTVKPGA AFSVLACYNG RPTGTFTVVM RPNYTIKGSF LCGSCGSVGY
3410 3420 3430 3440 3450
TKEGSVINFC YMHQMELANG THTGSAFDGT MYGAFMDKQV HQVQLTDKYC
3460 3470 3480 3490 3500
SVNVVAWLYA AILNGCAWFV KPNRTSVVSF NEWALANQFT EFVGTQSVDM
3510 3520 3530 3540 3550
LAVKTGVAIE QLLYAIQQLY TGFQGKQILG STMLEDEFTP EDVNMQIMGV
3560 3570 3580 3590 3600
VMQSGVRKVT YGTAHWLFAT LVSTYVIILQ ATKFTLWNYL FETIPTQLFP
3610 3620 3630 3640 3650
LLFVTMAFVM LLVKHKHTFL TLFLLPVAIC LTYANIVYEP TTPISSALIA
3660 3670 3680 3690 3700
VANWLAPTNA YMRTTHTDIG VYISMSLVLV IVVKRLYNPS LSNFALALCS
3710 3720 3730 3740 3750
GVMWLYTYSI GEASSPIAYL VFVTTLTSDY TITVFVTVNL AKVCTYAIFA
3760 3770 3780 3790 3800
YSPQLTLVFP EVKMILLLYT CLGFMCTCYF GVFSLLNLKL RAPMGVYDFK
3810 3820 3830 3840 3850
VSTQEFRFMT ANNLTAPRNS WEAMALNFKL IGIGGTPCIK VAAMQSKLTD
3860 3870 3880 3890 3900
LKCTSVVLLS VLQQLHLEAN SRAWAFCVKC HNDILAATDP SEAFEKFVSL
3910 3920 3930 3940 3950
FATLMTFSGN VDLDALASDI FDTPSVLQAT LSEFSHLATF AELEAAQKAY
3960 3970 3980 3990 4000
QEAMDSGDTS PQVLKALQKA VNIAKNAYEK DKAVARKLER MADQAMTSMY
4010 4020 4030 4040 4050
KQARAEDKKA KIVSAMQTML FGMIKKLDND VLNGIISNAR NGCIPLSVIP
4060 4070 4080 4090 4100
LCASNKLRVV IPDFTVWNQV VTYPSLNYAG ALWDITVINN VDNEIVKSSD
4110 4120 4130 4140 4150
VVDSNENLTW PLVLECTRAS TSAVKLQNNE IKPSGLKTMV VSAGQEQTNC
4160 4170 4180 4190 4200
NTSSLAYYEP VQGRKMLMAL LSDNAYLKWA RVEGKDGFVS VELQPPCKFL
4210 4220 4230 4240 4250
IAGPKGPEIR YLYFVKNLNN LHRGQVLGHI AATVRLQAGS NTEFASNSSV
4260 4270 4280 4290 4300
LSLVNFTVDP QKAYLDFVNA GGAPLTNCVK MLTPKTGTGI AISVKPESTA
4310 4320 4330 4340 4350
DQETYGGASV CLYCRAHIEH PDVSGVCKYK GKFVQIPAQC VRDPVGFCLS
4360 4370 4380 4390 4400
NTPCNVCQYW IGYGCNCDSL RQAALPQSKD SNFLNRVRGS IVNARIEPCS
4410 4420 4430 4440 4450
SGLSTDVVFR AFDICNYKAK VAGIGKYYKT NTCRFVELDD QGHHLDSYFV
4460 4470 4480 4490 4500
VKRHTMENYE LEKHCYDLLR DCDAVAPHDF FIFDVDKVKT PHIVRQRLTE
4510 4520 4530 4540 4550
YTMMDLVYAL RHFDQNSEVL KAILVKYGCC DVTYFENKLW FDFVENPSVI
4560 4570 4580 4590 4600
GVYHKLGERV RQAILNTVKF CDHMVKAGLV GVLTLDNQDL NGKWYDFGDF
4610 4620 4630 4640 4650
VITQPGSGVA IVDSYYSYLM PVLSMTDCLA AETHRDCDFN KPLIEWPLTE
4660 4670 4680 4690 4700
YDFTDYKVQL FEKYFKYWDQ TYHANCVNCT DDRCVLHCAN FNVLFAMTMP
4710 4720 4730 4740 4750
KTCFGPIVRK IFVDGVPFVV SCGYHYKELG LVMNMDVSLH RHRLSLKELM
4760 4770 4780 4790 4800
MYAADPAMHI ASSNAFLDLR TSCFSVAALT TGLTFQTVRP GNFNQDFYDF
4810 4820 4830 4840 4850
VVSKGFFKEG SSVTLKHFFF AQDGNAAITD YNYYSYNLPT MCDIKQMLFC
4860 4870 4880 4890 4900
MEVVNKYFEI YDGGCLNASE VVVNNLDKSA GHPFNKFGKA RVYYESMSYQ
4910 4920 4930 4940 4950
EQDELFAMTK RNVIPTMTQM NLKYAISAKN RARTVAGVSI LSTMTNRQYH
4960 4970 4980 4990 5000
QKMLKSMAAT RGATCVIGTT KFYGGWDFML KTLYKDVDNP HLMGWDYPKC
5010 5020 5030 5040 5050
DRAMPNMCRI FASLILARKH GTCCTTRDRF YRLANECAQV LSEYVLCGGG
5060 5070 5080 5090 5100
YYVKPGGTSS GDATTAYANS VFNILQATTA NVSALMGANG NKIVDKEVKD
5110 5120 5130 5140 5150
MQFDLYVNVY RSTSPDPKFV DKYYAFLNKH FSMMILSDDG VVCYNSDYAA
5160 5170 5180 5190 5200
KGYIAGIQNF KETLYYQNNV FMSEAKCWVE TDLKKGPHEF CSQHTLYIKD
5210 5220 5230 5240 5250
GDDGYFLPYP DPSRILSAGC FVDDIVKTDG TLMVERFVSL AIDAYPLTKH
5260 5270 5280 5290 5300
EDIEYQNVFW VYLQYIEKLY KDLTGHMLDS YSVMLCGDNS AKFWEEAFYR
5310 5320 5330 5340 5350
DLYSSPTTLQ AVGSCVVCHS QTSLRCGTCI RRPFLCCKCC YDHVIATPHK
5360 5370 5380 5390 5400
MVLSVSPYVC NAPGCGVSDV TKLYLGGMSY FCVDHRPVCS FPLCANGLVF
5410 5420 5430 5440 5450
GLYKNMCTGS PSIVEFNRLA TCDWTESGDY TLANTTTEPL KLFAAETLRA
5460 5470 5480 5490 5500
TEEASKQSYA IATIKEIVGE RQLLLVWEAG KSKPPLNRNY VFTGYHITKN
5510 5520 5530 5540 5550
SKVQLGEYIF ERIDYSDAVS YKSSTTYKLT VGDIFVLTSH SVATLTAPTI
5560 5570 5580 5590 5600
VNQERYVKIT GLYPTITVPE EFASHVANFQ KSGYSKYVTV QGPPGTGKSH
5610 5620 5630 5640 5650
FAIGLAIYYP TARVVYTACS HAAVDALCEK AFKYLNIAKC SRIIPAKARV
5660 5670 5680 5690 5700
ECYDRFKVNE TNSQYLFSTI NALPETSADI LVVDEVSMCT NYDLSIINAR
5710 5720 5730 5740 5750
IKAKHIVYVG DPAQLPAPRT LLTRGTLEPE NFNSVTRLMC NLGPDIFLSM
5760 5770 5780 5790 5800
CYRCPKEIVS TVSALVYNNK LLAKKELSGQ CFKILYKGNV THDASSAINR
5810 5820 5830 5840 5850
PQLTFVKNFI TANPAWSKAV FISPYNSQNA VSRSMLGLTT QTVDSSQGSE
5860 5870 5880 5890 5900
YQYVIFCQTA DTAHANNINR FNVAITRAQK GILCVMTSQA LFESLEFTEL
5910 5920 5930 5940 5950
SFTNYKLQSQ IVTGLFKDCS RETSGLSPAY APTYVSVDDK YKTSDELCVN
5960 5970 5980 5990 6000
LNLPANVPYS RVISRMGFKL DATVPGYPKL FITREEAVRQ VRSWIGFDVE
6010 6020 6030 6040 6050
GAHASRNACG TNVPLQLGFS TGVNFVVQPV GVVDTEWGNM LTGIAARPPP
6060 6070 6080 6090 6100
GEQFKHLVPL MHKGAAWPIV RRRIVQMLSD TLDKLSDYCT FVCWAHGFEL
6110 6120 6130 6140 6150
TSASYFCKIG KEQKCCMCNR RAAAYSSPLQ SYACWTHSCG YDYVYNPFFV
6160 6170 6180 6190 6200
DVQQWGYVGN LATNHDRYCS VHQGAHVASN DAIMTRCLAI HSCFIERVDW
6210 6220 6230 6240 6250
DIEYPYISHE KKLNSCCRIV ERNVVRAALL AGSFDKVYDI GNPKGIPIVD
6260 6270 6280 6290 6300
DPVVDWHYFD AQPLTRKVQQ LFYTEDMASR FADGLCLFWN CNVPKYPNNA
6310 6320 6330 6340 6350
IVCRFDTRVH SEFNLPGCDG GSLYVNKHAF HTPAYDVSAF RDLKPLPFFY
6360 6370 6380 6390 6400
YSTTPCEVHG NGSMIEDIDY VPLKSAVCIT ACNLGGAVCR KHATEYREYM
6410 6420 6430 6440 6450
EAYNLVSASG FRLWCYKTFD IYNLWSTFTK VQGLENIAFN VVKQGHFIGV
6460 6470 6480 6490 6500
EGELPVAVVN DKIFTKSGVN DICMFENKTT LPTNIAFELY AKRAVRSHPD
6510 6520 6530 6540 6550
FKLLHNLQAD ICYKFVLWDY ERSNIYGTAT IGVCKYTDID VNSALNICFD
6560 6570 6580 6590 6600
IRDNCSLEKF MSTPNAIFIS DRKIKKYPCM VGPDYAYFNG AIIRDSDVVK
6610 6620 6630 6640 6650
QPVKFYLYKK VNNEFIDPTE CIYTQSRSCS DFLPLSDMEK DFLSFDSDVF
6660 6670 6680 6690 6700
IKKYGLENYA FEHVVYGDFS HTTLGGLHLL IGLYKKQQEG HIIMEEMLKG
6710 6720 6730 6740 6750
SSTIHNYFIT ETNTAAFKAV CSVIDLKLDD FVMILKSQDL GVVSKVVKVP
6760 6770 6780 6790 6800
IDLTMIEFML WCKDGQVQTF YPRLQASADW KPGHAMPSLF KVQNVNLERC
6810 6820 6830 6840 6850
ELANYKQSIP MPRGVHMNIA KYMQLCQYLN TCTLAVPANM RVIHFGAGSD
6860 6870 6880 6890 6900
KGIAPGTSVL RQWLPTDAII IDNDLNEFVS DADITLFGDC VTVRVGQQVD
6910 6920 6930 6940 6950
LVISDMYDPT TKNVTGSNES KALFFTYLCN LINNNLALGG SVAIKITEHS
6960 6970 6980 6990 7000
WSVELYELMG KFAWWTVFCT NANASSSEGF LLGINYLGTI KENIDGGAMH
7010 7020 7030 7040 7050
ANYIFWRNST PMNLSTYSLF DLSKFQLKLK GTPVLQLKES QINELVISLL
7060 7070
SQGKLLIRDN DTLSVSTDVL VNTYRKLR
Length:7,078
Mass (Da):789,461
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3258BB881E7605D4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX869059 Genomic RNA Translation: AFS88944.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX869059 Genomic RNA Translation: AFS88944.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P16X-ray2.50A1482-1801[»]
5V69X-ray2.55A1480-1803[»]
5V6AX-ray2.70A1480-1803[»]
5WWPX-ray3.00A/B5311-5908[»]
5YN5X-ray1.96A6776-7078[»]
5YN6X-ray1.95A6776-7078[»]
5YN8X-ray1.97A6776-7078[»]
5YNBX-ray1.98A6776-7078[»]
5YNFX-ray1.79A6776-7078[»]
5YNIX-ray2.07A6776-7078[»]
5YNJX-ray2.04A6776-7078[»]
5YNMX-ray1.68A6776-7078[»]
5YNNX-ray1.86A6776-7078[»]
5YNOX-ray1.96A6776-7078[»]
5YNPX-ray2.27A6776-7078[»]
5YNQX-ray1.96A6776-7078[»]
6BI8X-ray2.29A/B1544-1801[»]
SMRiK0BWD0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-5789, MERS-CoV NSP10-NSP16 2'-O-methyltransferase complex
IntActiK0BWD0, 2 interactors

Protein family/group databases

MEROPSiC30.006

Family and domain databases

CDDicd21409, 1B_cv_Nsp13-like, 1 hit
cd21560, betaCoV-Nsp6, 1 hit
cd21659, betaCoV_Nsp14, 1 hit
cd21666, betaCoV_Nsp5_Mpro, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21517, cv_beta_Nsp2_MERS-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21165, M_cv-Nsp15-like, 1 hit
cd21563, Macro_cv_SUD-M_Nsp3-like, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21592, MERS-CoV-like_RdRp, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit
cd21523, SUD_C_MERS-CoV_Nsp3, 1 hit
cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit
Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.50.11020, 1 hit
3.40.50.11580, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR042570, NAR_sf
IPR043609, NendoU_nidovirus
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR044315, NSP14_betaCoV
IPR009466, NSP14_CoV
IPR044330, NSP15_alpha_betaCoV_N
IPR044327, NSP15_M_betaCoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR021590, NSP1_bCoV
IPR044388, NSP2_MERS-like
IPR043615, NSP2_N_CoV
IPR024375, NSP3_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR044382, NSP3_SUD_C_MERS-CoV
IPR044357, NSP3_Ubl1_dom_CoV
IPR044353, Nsp3_Ubl2_dom_CoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044367, NSP6_betaCoV
IPR043610, NSP6_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR044350, RdRp_MERS-CoV-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF13087, AAA_12, 1 hit
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK0BWD0_MERS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K0BWD0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 2, 2021
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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