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Entry version 41 (02 Jun 2021)
Sequence version 1 (28 Nov 2012)
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Protein
Submitted name:

2-isopropylmalate synthase

Gene

CNAG_05496

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseARBA annotation
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
2-isopropylmalate synthaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CNAG_05496Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:CNAG_05496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
J9VZR6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 319Pyruvate carboxyltransferaseInterPro annotationAdd BLAST287

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni477 – 522DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi477 – 502Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.ARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_004588_3_0_1

Family and domain databases

Conserved Domains Database

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CDDi
cd07942, DRE_TIM_LeuA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.20.20.70, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00572, LeuA_type2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013709, 2-isopropylmalate_synth_dimer
IPR002034, AIPM/Hcit_synth_CS
IPR013785, Aldolase_TIM
IPR005668, IPM_Synthase
IPR036230, LeuA_allosteric_dom_sf
IPR039371, LeuA_N_DRE-TIM
IPR000891, PYR_CT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00682, HMGL-like, 1 hit
PF08502, LeuA_dimer, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00917, LeuA_dimer, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF110921, SSF110921, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00815, AIPM_HOMOCIT_SYNTH_1, 1 hit
PS00816, AIPM_HOMOCIT_SYNTH_2, 1 hit
PS50991, PYR_CT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9VZR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMLSDPSKR YLPFQPVPFP NRTWPDKTHK KAPIWLSTDL RDGNQSLANP
60 70 80 90 100
MTNQQKLRFF RHLVQLGFKE IEVAYPAASE TDYNFVRELI DRKEVPDDVW
110 120 130 140 150
IQVLTPARAD LIKRTFEAVA GLKHVIVHMY NATSCLFREV VFNNDRDETV
160 170 180 190 200
KLAKDHTILI RQLAEKYAES HGTSFRYEYS PETFSQTETP YAVEVCEAVK
210 220 230 240 250
KAWLGGHGSV WADGRKEERI IFNLPATVEV ATPNCFADQV EIFCNSISER
260 270 280 290 300
EKCIISLHTH NDRGCAVAAA ELGVLAGADR IEGTVLGNGE RTGNVDLVTL
310 320 330 340 350
ALNCYSQGIS PNLDFSDMFS VIDTVTECTG LPVHPRHPYA GELVFTAFSG
360 370 380 390 400
SHQDAIKKGF EAQAKRDNAG GKVWSMPYLP IDPADVGCTY EAVIRVNSQS
410 420 430 440 450
GKGGIAYIVK SALSLDLPRR MQIAFYKVVQ ECSEATGKEM TSKDITTAFR
460 470 480 490 500
QTYHLGGSIY DGRLVLKSFV TVDLHSSQTP SVAGTPDLSP IRSRSQTRMP
510 520 530 540 550
PLSLSGGVAE PSPDRNLDRN LPSMSKRLTG KVLVDGKLHE IVGEGNGPLS
560 570 580 590 600
SFLNALESDL GIVLSVREYT EHAVGAGSDV KAATYVELIP ANVDAKDKTQ
610 620 630
GGFWGVGVDA DITASGLKAV VSAANGFLGQ GPIPSQNSV
Length:639
Mass (Da):69,867
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B34B1E428104DF2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003833 Genomic DNA Translation: AFR98921.1

NCBI Reference Sequences

More...
RefSeqi
XP_012053808.1, XM_012198418.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR98921; AFR98921; CNAG_05496

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23888801

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003833 Genomic DNA Translation: AFR98921.1
RefSeqiXP_012053808.1, XM_012198418.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiJ9VZR6

Genome annotation databases

EnsemblFungiiAFR98921; AFR98921; CNAG_05496
GeneIDi23888801

Organism-specific databases

VEuPathDBiFungiDB:CNAG_05496

Phylogenomic databases

HOGENOMiCLU_004588_3_0_1

Family and domain databases

CDDicd07942, DRE_TIM_LeuA, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00572, LeuA_type2, 1 hit
InterProiView protein in InterPro
IPR013709, 2-isopropylmalate_synth_dimer
IPR002034, AIPM/Hcit_synth_CS
IPR013785, Aldolase_TIM
IPR005668, IPM_Synthase
IPR036230, LeuA_allosteric_dom_sf
IPR039371, LeuA_N_DRE-TIM
IPR000891, PYR_CT
PfamiView protein in Pfam
PF00682, HMGL-like, 1 hit
PF08502, LeuA_dimer, 1 hit
SMARTiView protein in SMART
SM00917, LeuA_dimer, 1 hit
SUPFAMiSSF110921, SSF110921, 1 hit
PROSITEiView protein in PROSITE
PS00815, AIPM_HOMOCIT_SYNTH_1, 1 hit
PS00816, AIPM_HOMOCIT_SYNTH_2, 1 hit
PS50991, PYR_CT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9VZR6_CRYNH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9VZR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 2, 2021
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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