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Entry version 46 (31 Jul 2019)
Sequence version 1 (28 Nov 2012)
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Protein

Clustered mitochondria protein homolog

Gene

CLU1

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.UniRule annotationSAAS annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clustered mitochondria protein homologUniRule annotation
Alternative name(s):
Protein TIF31 homologUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLU1UniRule annotation
Synonyms:TIF31UniRule annotation
ORF Names:CNAG_06248Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CNAG_06248

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
J9VYI2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini399 – 693CluInterPro annotationAdd BLAST295

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 61DisorderedSequence analysisAdd BLAST61
Regioni571 – 615DisorderedSequence analysisAdd BLAST45
Regioni755 – 800DisorderedSequence analysisAdd BLAST46
Regioni1054 – 1080DisorderedSequence analysisAdd BLAST27
Regioni1380 – 1409DisorderedSequence analysisAdd BLAST30
Regioni1428 – 1501DisorderedSequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 40PolarSequence analysisAdd BLAST40
Compositional biasi583 – 606PolyampholyteSequence analysisAdd BLAST24
Compositional biasi755 – 779PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1054 – 1077PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1434 – 1460PolarSequence analysisAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLU family.UniRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15466 CLU-central, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_03013 CLU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13236 CLU, 1 hit
PF12807 eIF3_p135, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51823 CLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9VYI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESAQAAAQ NGQAEEQQLQ QQLDEQQQLE EQQQLPPVTI RIPSPTCVRT
60 70 80 90 100
VPRPKDSTEP LDRITLYPQP QETIQDIKLL INDWVGAYWL GPYSLQLPFV
110 120 130 140 150
KGEDGRGKIY SKKKDFSEVR AGEKLNEWLE VQDAFEHLKE GEERVLEAVR
160 170 180 190 200
EPYGELSARQ SIIRLLELIA PSGTTANTTS NPLGLQAGST IFEQVRDGVV
210 220 230 240 250
SANAETTYEE VEVSLPSGRK GKGGKKELIK VKRAVSGDKA HAFAGWKEWA
260 270 280 290 300
PASFGSLAVA SDPVEVAPSL KSIQISHFNP PPPHLRQKGH ELYLQVSLLE
310 320 330 340 350
GEVVTLVCST RGWYVSKSNV NNFDPSPRPS ADGSIPAPTH SLIDLLHSIS
360 370 380 390 400
PLFSERVSKL PPISLEGALA DPISTVAIPQ ATPAYPFLAS APKPDISPEI
410 420 430 440 450
LRTQLAFLHT GAYGPDLVDA ARDWNEEIQG IRELPRGTMQ ERVFREKMLQ
460 470 480 490 500
KVWAEFDQAA ARAVQAVSKG DIPPINPAED PKAHMYLQSN IFITQGDSDA
510 520 530 540 550
LDTYAHLGGD AAMRISHGKD AAGVKLLNKI DADGLYLLGH TIVDWQGRRW
560 570 580 590 600
ICQSILPGIF SNRRAVDEEK AQAEAEAEAE TANAAEGEQK KEDWVDVEKP
610 620 630 640 650
TEKSGSETES DNPMMVYGLD SERPTSIHWD AATHSLLSTI ATPLRLAAHS
660 670 680 690 700
IKDGEGKEHE FYASAEVKGL KGQDGRRYLL DAQRLSPVDV EWLEKDIIGP
710 720 730 740 750
LVGPKKDVES TEEGVEYPHR LVMLRPELIE QFWESELKRW ARGVAEKAQA
760 770 780 790 800
KKAEADAEAA AAADAEGEKK KEGEKSEIPQ EEQSPAASAA AAHRAEEDRP
810 820 830 840 850
VDASLIGDIK QFNLSFNPDA FVEQPVPEAE GQEGKPEIKV AITDESDPSV
860 870 880 890 900
KAVRDAGLFL RQIAIPAVVL DVLTGNTSGV MDGESLSKHL HQRGVNIRYL
910 920 930 940 950
GYLASTIIQF STSKDGAAKE PSGHLAALQS IVLQEMVFRA AKHILRELLY
960 970 980 990 1000
PLQPETATDA ISHFLNCLLG SSLNPAPVAS YTPIGININE PEPAYVKLTP
1010 1020 1030 1040 1050
EDLRAQVIKE VKSRFRWTLD ESFLENGLRK KQLLRELATR VGFQLTQREY
1060 1070 1080 1090 1100
VFSKDQEEEE KREEDVKSKE KKKGSKGGAK VQAVKRTTTF EGEDILTLVP
1110 1120 1130 1140 1150
VIKSTAPSVS VAEEILEAGR NTINRGKIEF GLDFMLEAIQ LYESIHSVIH
1160 1170 1180 1190 1200
PEVASVYNSY AQAIHQIARL KIQQIAAQEN PDPEQPLGVD ISGALRFQRQ
1210 1220 1230 1240 1250
AVAIAERTLG VYHHETAGYY FQLAMLENLE GNAQQSLRYF RHLLTLWDVI
1260 1270 1280 1290 1300
YGPGHPEIST ILSNAGIVLQ SMNDLPLSLS LQKQAHKSTL ASFGPNHIQT
1310 1320 1330 1340 1350
GQSLHQLVQG HFLAGDMASA LETAKQALEI FKARLGEEHN QTKEEAKNVE
1360 1370 1380 1390 1400
LLTAVIENQE RQKEREEAVK KEATERLKMA RERIGGGAAS ASRPTGIRRL
1410 1420 1430 1440 1450
GGSGAGTLPQ GVRVVDPQTL AALAAAAGQG GNPSANAAAA TAGQGEQANG
1460 1470 1480 1490 1500
ESTGTPQIGE RGTESLEELV RYIQGSAPGA GGSAKRGKNA LRGKRRTGAK

R
Length:1,501
Mass (Da):164,095
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3542C68351B098F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003831 Genomic DNA Translation: AFR98476.1

NCBI Reference Sequences

More...
RefSeqi
XP_012053231.1, XM_012197841.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR98476; AFR98476; CNAG_06248

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23889474

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003831 Genomic DNA Translation: AFR98476.1
RefSeqiXP_012053231.1, XM_012197841.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiJ9VYI2

Genome annotation databases

EnsemblFungiiAFR98476; AFR98476; CNAG_06248
GeneIDi23889474

Organism-specific databases

EuPathDBiFungiDB:CNAG_06248

Family and domain databases

CDDicd15466 CLU-central, 1 hit
Gene3Di1.25.40.10, 2 hits
HAMAPiMF_03013 CLU, 1 hit
InterProiView protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13236 CLU, 1 hit
PF12807 eIF3_p135, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS51823 CLU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9VYI2_CRYNH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9VYI2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 31, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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