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Entry version 41 (03 Jul 2019)
Sequence version 1 (28 Nov 2012)
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Protein

Clathrin heavy chain

Gene

CNAG_04904

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin heavy chainUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CNAG_04904Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CNAG_04904

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Coated pitUniRule annotation, Cytoplasmic vesicleUniRule annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
J9VV68

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini342 – 365Clathrin-linkInterPro annotationAdd BLAST24
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati549 – 695CHCRPROSITE-ProRule annotationAdd BLAST147
Repeati698 – 840CHCRPROSITE-ProRule annotationAdd BLAST143
Repeati845 – 984CHCRPROSITE-ProRule annotationAdd BLAST140
Repeati991 – 1136CHCRPROSITE-ProRule annotationAdd BLAST146
Repeati1140 – 1281CHCRPROSITE-ProRule annotationAdd BLAST142
Repeati1286 – 1431CHCRPROSITE-ProRule annotationAdd BLAST146
Repeati1434 – 1577CHCRPROSITE-ProRule annotationAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1614 – 1634Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clathrin heavy chain family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits
2.130.10.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00637 Clathrin, 7 hits
PF09268 Clathrin-link, 1 hit
PF01394 Clathrin_propel, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002290 Clathrin_H_chain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00299 CLH, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50236 CHCR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9VV68-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPEKPIVF TEHLQLTALG IQPTSISFQT LTLESDAWIC VRETGDTPQV
60 70 80 90 100
VIVNLNDAGD VVRRPITADS AIMNPRANEK ILALKAGRQL QVFNLGAKAK
110 120 130 140 150
LGTHLMNDDV TFWTWINDTT LGIVTEREVY HWKVMDGQAA PTKVFDRHAN
160 170 180 190 200
LTANQIINYR ISHDEKWLVL VGISSNPNAG QPGENGFKIK GAMQLYSIER
210 220 230 240 250
GVSQPIEGHA ATFASIKLDG APNPTKLFAF AVRTAAGAKL HIVEIGHQAP
260 270 280 290 300
NPPFQKKAVD VFFPAEALND FPVSLQISQK HGILYLVTKF GFIHLYEIET
310 320 330 340 350
GQCIYMNRIS GETIFTTAEY ETLSGIIGVN RKGQVLSVSV DEQTVVPYIQ
360 370 380 390 400
QTLNNPELAI KLATRAGLPG ADGMIQQQYQ VYIQNGQYGE AAKVAANSPR
410 420 430 440 450
GLLRTPQTIE TLKNLPAVPG TLTPILQYFG ILLEKGELNK YESLELARPV
460 470 480 490 500
VQQGKKQLLE KWLKENKLES SEELGDLCRM ADMNLALSVY LRANVPNKVV
510 520 530 540 550
ACFAELGQFD KIVLYSKKVG YTPDYAQLLQ HLVRINPDKG AEFATQLVND
560 570 580 590 600
ENGPLVDLDR IVDIFMSQNM LQQATSILLD ALKDNKPEQG PLQTRLLEMN
610 620 630 640 650
LMSAPQVADA ILGNEMFTHY DRPRIANLAE KAGLVQRALE HYEDINDIKR
660 670 680 690 700
VVVHTNLFKP EWLVDYFGRL TVEQSFACLQ EMLRTNLRQN LPIVVQIATK
710 720 730 740 750
YSDLLGSVKL IELFEQFKSS DGLYYYLGSI VNLSEDPEVH FKYIQAATRT
760 770 780 790 800
GQIREVERIC RESNFYNPEK VKNFLKEARL DDQLPLIIVC DRFDFVHDLV
810 820 830 840 850
LYLYQNGLTN FIEIYVQRVN SARTPQVIGG LLDVDCDETT VKNLLMSVTG
860 870 880 890 900
TFPIDDLVDE VEKRNRLKLI LPWLNNKVEQ GSTDHAVYNA IAKISIDSNN
910 920 930 940 950
NPEKFLKENN LYDPAIVGKY CEKRDPYLAY IAYAKGFCDD ELINITNENQ
960 970 980 990 1000
MYKHQARYLV KRRDVDLWTQ VLNPESIHRR ALIDQIIATA IPESVDPDDV
1010 1020 1030 1040 1050
SVTVKAFMHM ELHGPLLELL EKIIIEPSPF SDNRSLQSLM FLTAIKNDKG
1060 1070 1080 1090 1100
KVMGYINRLS GYDVETIAKV ATEAGLYEEA FTIYQKHDMH AEAMSVLVEH
1110 1120 1130 1140 1150
MASIDRGFAY ANKINEPAVW SRLGKAQLDG LRVKEAIDSY IKADDPSNFE
1160 1170 1180 1190 1200
EVIEIANRAG KHDDLVRYLQ MARKTAREPK IDTELAYAYA KTDRLHDMEE
1210 1220 1230 1240 1250
FLGMTNVADV LQVGEKCFDD ELYQAAKLLF SSISNWARLA TTLIYLGENQ
1260 1270 1280 1290 1300
VAVDAARKAG NTQVWKQVNA ACVDKKEFRL AQICGLNLVV HAEELPALLS
1310 1320 1330 1340 1350
LYERNGYFDE IISLMEAGLG LERAHMGMFT ELSVLYAKYR PEKLMEHLKL
1360 1370 1380 1390 1400
FWQRVNIPKV IKAAEQAHLW PELVFLYIVY DEPDNASLAM MERLADWDHD
1410 1420 1430 1440 1450
QFKKVIVKVA NMEIAYRAVS FYLARQPTLL PDLLAALTPR LDHSRVIKIL
1460 1470 1480 1490 1500
QTEDHLPLAK PYLIATQKLN LAVINEAYND LLIEEEDHIT LRSSLETYDE
1510 1520 1530 1540 1550
YDAIKLAKRL EKHELLEFRR IAALLYRLNS LWEESISLSK ADRLWRDALE
1560 1570 1580 1590 1600
TAAASKDIAV CEELAGYFVS IGNKDAFAAI LYVCFEFVRA DFVEEMSWRF
1610 1620 1630 1640 1650
GLSDYSMPYK LQQQRDQATK IAALEKEVKE LRTKTAEKEP DNEPSSLMGS
1660 1670 1680
GLGGRLMIGG PSGGPPFMGS MPNGGMMAQP TGFY
Length:1,684
Mass (Da):190,067
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0562ACB14278DD08
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003829 Genomic DNA Translation: AFR97311.1

NCBI Reference Sequences

More...
RefSeqi
XP_012052289.1, XM_012196899.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR97311; AFR97311; CNAG_04904

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23888279

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003829 Genomic DNA Translation: AFR97311.1
RefSeqiXP_012052289.1, XM_012196899.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiJ9VV68

Genome annotation databases

EnsemblFungiiAFR97311; AFR97311; CNAG_04904
GeneIDi23888279

Organism-specific databases

EuPathDBiFungiDB:CNAG_04904

Family and domain databases

Gene3Di1.25.40.10, 3 hits
2.130.10.110, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00637 Clathrin, 7 hits
PF09268 Clathrin-link, 1 hit
PF01394 Clathrin_propel, 1 hit
PIRSFiPIRSF002290 Clathrin_H_chain, 1 hit
SMARTiView protein in SMART
SM00299 CLH, 7 hits
SUPFAMiSSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9VV68_CRYNH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9VV68
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 3, 2019
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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