UniProtKB - J9VT60 (LARP1_CRYNH)
Protein
La RNA-binding domain-containing protein LHP1
Gene
LHP1
Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Functioni
May act as an RNA-binding protein.Curated
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: La RNA-binding domain-containing protein LHP1Curated |
Gene namesi | Name:LHP11 Publication ORF Names:CNAG_04570Imported |
Organismi | Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported |
Taxonomic identifieri | 235443 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Cryptococcaceae › Cryptococcus › Cryptococcus neoformans species complex › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:CNAG_04570 |
Pathology & Biotechi
Disruption phenotypei
Sensitive to various stresses including heat, sodium dodecyl sulfate and calcineurin inhibitor tacrolimus (PubMed:27611567). Resistant to tunicamycin-induced ER stress (PubMed:27611567). Simultaneous disruption of CRZ1 enhances thermosensitivity and decreases virulence in a mouse intranasal inhalation model for pulmonary infection (PubMed:27611567).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000451160 | 1 – 895 | La RNA-binding domain-containing protein LHP1Add BLAST | 895 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 847 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinPTM databases
SwissPalmi | J9VT60 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 706 – 796 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 91 |
Phylogenomic databases
HOGENOMi | CLU_324910_0_0_1 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
i Sequence
Sequence statusi: Complete.
J9VT60-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPSQQQTSV FNALGSYADR IKDANGNFIK SSPSSSSSAT PEPTSLSSST
60 70 80 90 100
SGKKAFSTAT SKSGQQKQGS SPQPGAITAE DDGPWETVQS TRARQRTDRS
110 120 130 140 150
EEKEKRGSSS KNWRERSHRD EKNQDDGEKR NGRERSKKEK GDKSNSAPFV
160 170 180 190 200
GSATSSEKTA KSLSSSTKNA WGVTSSSQGE NPIASNPGPK QKAQNDSTFR
210 220 230 240 250
SSSAAAPVGP TTSTINEIIK QSEGSDEDNW RARPAKVEKN EKTEGPVSIT
260 270 280 290 300
QAQPQPQRQL APPPSVNIWD LRKKMSVPVL VSPTSATSAV AGIPPKSDKE
310 320 330 340 350
KSLTNGMVKE EDSGTGKSLS KKKSAAAAAA AGTSSTPPSI HDATLWPDII
360 370 380 390 400
QAAEVVKAGE DKKEKAKERL NSESASVAEE STIGIGKKPK WTPIPAHELL
410 420 430 440 450
AAADHAAEQS RRQNRMEAKK RSSGREGGES GPTGSGAPGK SNKTRKGMPA
460 470 480 490 500
AEGKKARKEG AQQKDGHASS KAGETIGAGT GKANGDVKET KEGDARSASQ
510 520 530 540 550
QESSSHRSGP SISASANTGI DSSLHARTKS TPNASTTPLP PHTFNLASSS
560 570 580 590 600
NLPRSTRGRG EGRGSFGGGR ARGGFRSSGA LGHKGQLGHG YGHVHGQGQG
610 620 630 640 650
FGYGYGSPPM GVAGLPVEGI IYAPLNPGAG AGAGASPNLY QRGYGMGFQP
660 670 680 690 700
FYPAATAAAS AGEGGPTGAA AGDAAGVYDP AAAVYGNMGM YKSASMPPPP
710 720 730 740 750
MPQTVVPNLD PLRFYVLGQV EYYFSMQNLA MDFFLRQQMD SEGWIDIAMI
760 770 780 790 800
ASFNRIKSLT PETSIVRECM ILSNYLEVRE DKVRLSGAES HRWVLPDAAP
810 820 830 840 850
SKFGPDPRSP SLAEGAESSE ERDGAASGSQ SGLVTAGEEG AQGLQASPRR
860 870 880 890
MFGAQDVKDA LMKSSALSTV NGEIKEKEEV KAMENEGEES ENYEQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP003829 Genomic DNA Translation: AFR97647.1 |
RefSeqi | XP_012052065.1, XM_012196675.1 |
Genome annotation databases
EnsemblFungii | AFR97647; AFR97647; CNAG_04570 |
GeneIDi | 23887966 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP003829 Genomic DNA Translation: AFR97647.1 |
RefSeqi | XP_012052065.1, XM_012196675.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | J9VT60 |
Genome annotation databases
EnsemblFungii | AFR97647; AFR97647; CNAG_04570 |
GeneIDi | 23887966 |
Organism-specific databases
VEuPathDBi | FungiDB:CNAG_04570 |
Phylogenomic databases
HOGENOMi | CLU_324910_0_0_1 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LARP1_CRYNH | |
Accessioni | J9VT60Primary (citable) accession number: J9VT60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 7, 2020 |
Last sequence update: | November 28, 2012 | |
Last modified: | April 7, 2021 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |